IRAK3
Entrez ID: 11213
Full name: interleukin 1 receptor associated kinase 3
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TKL: IRAK
Chromosomal location: 12q14.3
Substructure location: Gatekeeper: 241 A-loop: [N/A] G-loop: [N/A] αC-helix: [N/A]
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IRAK3
Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex....
Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.
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GO - Biological processes (BP):
cytokine-mediated signaling pathway, interleukin-1-mediated signaling pathway, intracellular signal transduction, MyD88-dependent toll-like receptor signaling pathway, negative regulation of cytokine-mediated signaling pathway, negative regulation of innate immune response, negative regulation of in...
cytokine-mediated signaling pathway, interleukin-1-mediated signaling pathway, intracellular signal transduction, MyD88-dependent toll-like receptor signaling pathway, negative regulation of cytokine-mediated signaling pathway, negative regulation of innate immune response, negative regulation of interleukin-12 production, negative regulation of interleukin-6 production, negative regulation of macrophage cytokine production, negative regulation of MAP kinase activity, negative regulation of NF-kappaB transcription factor activity, negative regulation of protein catabolic process, negative regulation of protein-containing complex disassembly, negative regulation of toll-like receptor signaling pathway, negative regulation of tumor necrosis factor production, positive regulation of macrophage tolerance induction, positive regulation of NF-kappaB transcription factor activity, protein autophosphorylation, protein phosphorylation, regulation of protein-containing complex disassembly, response to exogenous dsRNA, response to interleukin-1, response to lipopolysaccharide, response to peptidoglycan, response to virus
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GO - Molecular function (MF):
ATP binding, magnesium ion binding, protein heterodimerization activity, protein homodimerization activity, protein serine/threonine kinase activity...
ATP binding, magnesium ion binding, protein heterodimerization activity, protein homodimerization activity, protein serine/threonine kinase activity
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GO - Cellular component (CC):
nucleus, plasma membrane, cytoplasm...
nucleus, plasma membrane, cytoplasm
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interleukin 1 receptor associated kinase 3
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Kaplan plot for IRAK3 in
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*NOTE: the Kaplan plots were collected from OncoLnc