STK24
Entrez ID: 8428
Full name: serine/threonine kinase 24
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: STE: STE20: YSK
Chromosomal location: 13q32.2
Substructure location: Gatekeeper: 111 A-loop: 173...184, 186...196 G-loop: 42...48 αC-helix: 76...88
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STK24
Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK...
Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Regulates also cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.
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GO - Biological processes (BP):
activation of protein kinase activity, cellular response to starvation, execution phase of apoptosis, intrinsic apoptotic signaling pathway in response to oxidative stress, negative regulation of cell migration, protein autophosphorylation, protein phosphorylation, regulation of axon regeneration, r...
activation of protein kinase activity, cellular response to starvation, execution phase of apoptosis, intrinsic apoptotic signaling pathway in response to oxidative stress, negative regulation of cell migration, protein autophosphorylation, protein phosphorylation, regulation of axon regeneration, regulation of mitotic cell cycle, response to hydrogen peroxide, signal transduction, signal transduction by protein phosphorylation, stress-activated protein kinase signaling cascade
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GO - Molecular function (MF):
ATP binding, cadherin binding, metal ion binding, protein kinase activity, protein serine/threonine kinase activity...
ATP binding, cadherin binding, metal ion binding, protein kinase activity, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytosol, extracellular exosome, Golgi apparatus, nucleolus, nucleoplasm, nucleus, cytoplasm, membrane...
cytosol, extracellular exosome, Golgi apparatus, nucleolus, nucleoplasm, nucleus, cytoplasm, membrane
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serine/threonine kinase 24
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*NOTE: the Kaplan plots were collected from OncoLnc