BRAF
Drug: PLX-4720
Cancer code: BRCA
Cancer type: breast
Drug treatment table
| Cell line ID |
Cell line name |
Mutation in substructure |
IC50(uM) |
| SIDM00146 | MDA-MB-231 | G_loop (464) | 135.7882 |
| SIDM00146 | MDA-MB-231 | G_loop (464) | 172.9987 |
| SIDM00146 | MDA-MB-231 | G_loop (464) | 266.6649 |
| SIDM00872 | HCC1954 | None | 165.7448 |
| SIDM00866 | HCC1143 | None | 329.9648 |
| SIDM00885 | HCC1187 | None | 84.8572 |
| SIDM00884 | HCC1395 | None | 127.9868 |
| SIDM00874 | HCC1937 | None | 52.8597 |
| SIDM00774 | HCC2157 | None | 39.0019 |
| SIDM00675 | HCC38 | None | 155.4988 |
| SIDM00097 | T47D | None | 343.7848 |
| SIDM00148 | MCF7 | None | 13.9859 |
| SIDM00122 | BT-549 | None | 269.4843 |
| SIDM00135 | Hs-578-T | None | 90.7539 |
| SIDM00893 | BT-20 | None | 71.3417 |
| SIDM00954 | COLO-824 | None | 145.1635 |
| SIDM00940 | CAL-120 | None | 36.2132 |
| SIDM01001 | DU-4475 | None | 0.2116 |
| SIDM01056 | EFM-19 | None | 19.5168 |
| SIDM01042 | EVSA-T | None | 47.8678 |
| SIDM00882 | HCC1419 | None | 104.8095 |
| SIDM00878 | HCC1569 | None | 198.7944 |
| SIDM00673 | HCC70 | None | 36.1757 |
| SIDM00633 | MDA-MB-175-VII | None | 116.7653 |
| SIDM00528 | MDA-MB-361 | None | 174.8872 |
| SIDM00272 | MDA-MB-453 | None | 83.8654 |
| SIDM00628 | MDA-MB-468 | None | 90.1182 |
| SIDM00562 | MRK-nu-1 | None | 159.3422 |
| SIDM00241 | OCUB-M | None | 60.9383 |
| SIDM01186 | UACC-893 | None | 176.3698 |
| SIDM00971 | ZR-75-30 | None | 886.8253 |
| SIDM00898 | AU565 | None | 107.1477 |
| SIDM00928 | CAL-85-1 | None | 186.9997 |
| SIDM00933 | CAL-51 | None | 60.0325 |
| SIDM00332 | MFM-223 | None | 89.6627 |
| SIDM00630 | MDA-MB-415 | None | 276.5675 |
| SIDM00529 | MDA-MB-157 | None | 13.671 |
| SIDM00963 | BT-474 | None | 199.2075 |
| SIDM00920 | CAMA-1 | None | 141.6573 |
| SIDM00892 | BT-483 | None | 310.6559 |
| SIDM00629 | MDA-MB-436 | None | 167.5202 |
| SIDM01002 | EFM-192A | None | 101.5615 |
| SIDM00881 | HCC1428 | None | 113.5271 |
| SIDM00870 | HCC202 | None | 42.9045 |
| SIDM01062 | HDQ-P1 | None | 59.2235 |
| SIDM01037 | JIMT-1 | None | 17.1636 |
| SIDM00879 | HCC1500 | None | 95.6205 |
| SIDM00631 | MDA-MB-330 | None | 156.5008 |
| SIDM00872 | HCC1954 | None | 43.4091 |
| SIDM00866 | HCC1143 | None | 328.1412 |
| SIDM00885 | HCC1187 | None | 121.4321 |
| SIDM00884 | HCC1395 | None | 72.1574 |
| SIDM00874 | HCC1937 | None | 142.8494 |
| SIDM00774 | HCC2157 | None | 56.612 |
| SIDM00772 | HCC2218 | None | 202.1652 |
| SIDM00675 | HCC38 | None | 79.7303 |
| SIDM00097 | T47D | None | 88.5237 |
| SIDM00148 | MCF7 | None | 130.1481 |
| SIDM00122 | BT-549 | None | 94.5728 |
| SIDM00135 | Hs-578-T | None | 139.2688 |
| SIDM00893 | BT-20 | None | 176.2698 |
| SIDM00954 | COLO-824 | None | 44.6321 |
| SIDM00940 | CAL-120 | None | 42.0587 |
| SIDM01001 | DU-4475 | None | 0.9465 |
| SIDM01056 | EFM-19 | None | 276.8672 |
| SIDM01042 | EVSA-T | None | 88.9807 |
| SIDM00882 | HCC1419 | None | 226.4275 |
| SIDM00878 | HCC1569 | None | 64.9564 |
| SIDM00673 | HCC70 | None | 59.2909 |
| SIDM00633 | MDA-MB-175-VII | None | 170.8452 |
| SIDM00528 | MDA-MB-361 | None | 203.5505 |
| SIDM00272 | MDA-MB-453 | None | 182.1823 |
| SIDM00628 | MDA-MB-468 | None | 85.1714 |
| SIDM00562 | MRK-nu-1 | None | 232.9531 |
| SIDM00241 | OCUB-M | None | 35.9321 |
| SIDM01186 | UACC-893 | None | 101.5523 |
| SIDM00971 | ZR-75-30 | None | 471.7159 |
| SIDM00898 | AU565 | None | 125.677 |
| SIDM00928 | CAL-85-1 | None | 161.5882 |
| SIDM00933 | CAL-51 | None | 38.4323 |
| SIDM00332 | MFM-223 | None | 151.4024 |
| SIDM00630 | MDA-MB-415 | None | 228.834 |
| SIDM00529 | MDA-MB-157 | None | 147.9048 |
| SIDM00963 | BT-474 | None | 160.1274 |
| SIDM00920 | CAMA-1 | None | 280.8209 |
| SIDM00892 | BT-483 | None | 493.7814 |
| SIDM00629 | MDA-MB-436 | None | 111.7195 |
| SIDM01002 | EFM-192A | None | 162.7745 |
| SIDM00881 | HCC1428 | None | 148.6536 |
| SIDM00870 | HCC202 | None | 247.321 |
| SIDM01062 | HDQ-P1 | None | 31.7371 |
| SIDM01037 | JIMT-1 | None | 41.7257 |
| SIDM00879 | HCC1500 | None | 104.2398 |
| SIDM00631 | MDA-MB-330 | None | 86.0202 |
| SIDM00872 | HCC1954 | None | 43.8382 |
| SIDM00866 | HCC1143 | None | 90.8628 |
| SIDM00885 | HCC1187 | None | 267.2413 |
| SIDM00884 | HCC1395 | None | 56.9878 |
| SIDM00874 | HCC1937 | None | 153.7163 |
| SIDM00774 | HCC2157 | None | 98.2768 |
| SIDM00675 | HCC38 | None | 371.9956 |
| SIDM00097 | T47D | None | 88.7453 |
| SIDM00148 | MCF7 | None | 437.891 |
| SIDM00122 | BT-549 | None | 106.2249 |
| SIDM00135 | Hs-578-T | None | 15.7649 |
| SIDM00893 | BT-20 | None | 47.9057 |
| SIDM00954 | COLO-824 | None | 336.7022 |
| SIDM00940 | CAL-120 | None | 968.029 |
| SIDM01001 | DU-4475 | None | 0.3942 |
| SIDM01056 | EFM-19 | None | 176.6014 |
| SIDM01042 | EVSA-T | None | 56.944 |
| SIDM00882 | HCC1419 | None | 191.8673 |
| SIDM00878 | HCC1569 | None | 31.7173 |
| SIDM00673 | HCC70 | None | 27.4548 |
| SIDM00633 | MDA-MB-175-VII | None | 230.097 |
| SIDM00528 | MDA-MB-361 | None | 199.8124 |
| SIDM00272 | MDA-MB-453 | None | 140.0917 |
| SIDM00628 | MDA-MB-468 | None | 20.2846 |
| SIDM00562 | MRK-nu-1 | None | 70.7554 |
| SIDM00241 | OCUB-M | None | 42.7043 |
| SIDM00971 | ZR-75-30 | None | 214.1985 |
| SIDM00898 | AU565 | None | 119.6098 |
| SIDM00928 | CAL-85-1 | None | 108.3156 |
| SIDM01187 | UACC-812 | None | 71.0484 |
| SIDM00933 | CAL-51 | None | 131.0834 |
| SIDM00332 | MFM-223 | None | 209.4395 |
| SIDM00938 | CAL-148 | None | 81.8675 |
| SIDM00630 | MDA-MB-415 | None | 67.6826 |
| SIDM00529 | MDA-MB-157 | None | 365.3106 |
| SIDM00963 | BT-474 | None | 410.287 |
| SIDM00920 | CAMA-1 | None | 80.9164 |
| SIDM00892 | BT-483 | None | 1966.137 |
| SIDM00629 | MDA-MB-436 | None | 428.7852 |
| SIDM01002 | EFM-192A | None | 454.2683 |
| SIDM00881 | HCC1428 | None | 638.4191 |
| SIDM01062 | HDQ-P1 | None | 23.6639 |
| SIDM01037 | JIMT-1 | None | 160.1257 |
| SIDM00879 | HCC1500 | None | 189.8029 |
| SIDM00631 | MDA-MB-330 | None | 110.6873 |