BRAF
Drug: PLX-4720
Cancer code: SKCM
Cancer type: melanoma
Drug treatment table
| Cell line ID |
Cell line name |
Mutation in substructure |
IC50(uM) |
| SIDM00291 | HMV-II | G_loop (469) | 21.5116 |
| SIDM00291 | HMV-II | G_loop (469) | 51.9587 |
| SIDM00291 | HMV-II | G_loop (469) | 155.6419 |
| SIDM00003 | M14 | None | 0.7161 |
| SIDM00107 | UACC-62 | None | 0.6025 |
| SIDM00108 | UACC-257 | None | 5.8655 |
| SIDM00797 | A2058 | None | 23.3135 |
| SIDM00795 | A375 | None | 1.0704 |
| SIDM00140 | COLO-792 | None | 177.3533 |
| SIDM00284 | COLO-679 | None | 1.1234 |
| SIDM00890 | C32 | None | 1.3399 |
| SIDM00857 | G-361 | None | 3.0652 |
| SIDM00695 | HT-144 | None | 1.056 |
| SIDM01060 | IGR-1 | None | 16.3274 |
| SIDM00225 | IST-MEL1 | None | 14.3642 |
| SIDM00336 | MEL-JUSO | None | 387.8924 |
| SIDM00545 | Mewo | None | 310.2887 |
| SIDM01079 | SH-4 | None | 1.1976 |
| SIDM01107 | SK-MEL-1 | None | 13.6891 |
| SIDM01106 | SK-MEL-24 | None | 4.8807 |
| SIDM01000 | WM-115 | None | 5.4464 |
| SIDM01228 | CHL-1 | None | 71.3421 |
| SIDM01087 | RPMI-7951 | None | 19.6317 |
| SIDM00801 | A101D | None | 3.6961 |
| SIDM00543 | GAK | None | 171.0598 |
| SIDM00129 | G-MEL | None | 0.4552 |
| SIDM01066 | IGR-37 | None | 0.6414 |
| SIDM00975 | WM278 | None | 2.7913 |
| SIDM00976 | WM1552C | None | 16.21 |
| SIDM00974 | WM35 | None | 8.86 |
| SIDM00973 | WM793B | None | 8.1401 |
| SIDM00909 | COLO-829 | None | 2.716 |
| SIDM00175 | CP50-MEL-B | None | 0.3144 |
| SIDM00190 | CP66-MEL | None | 10.8011 |
| SIDM00185 | LB2518-MEL | None | 23.3236 |
| SIDM00184 | LB373-MEL-D | None | 172.0049 |
| SIDM00516 | MZ7-mel | None | 7.8042 |
| SIDM00081 | SK-MEL-28 | None | 0.7996 |
| SIDM00082 | SK-MEL-2 | None | 27.4276 |
| SIDM00080 | SK-MEL-5 | None | 1.9826 |
| SIDM00149 | LOXIMVI | None | 2.8132 |
| SIDM00003 | M14 | None | 0.3271 |
| SIDM00107 | UACC-62 | None | 76.4739 |
| SIDM00108 | UACC-257 | None | 1.5555 |
| SIDM00797 | A2058 | None | 9.5257 |
| SIDM00795 | A375 | None | 0.3666 |
| SIDM00515 | COLO-800 | None | 107.8543 |
| SIDM00140 | COLO-792 | None | 155.2651 |
| SIDM00284 | COLO-679 | None | 1.1371 |
| SIDM00890 | C32 | None | 0.2274 |
| SIDM00857 | G-361 | None | 3.1263 |
| SIDM00695 | HT-144 | None | 0.8578 |
| SIDM01060 | IGR-1 | None | 11.1957 |
| SIDM01059 | IPC-298 | None | 13.7728 |
| SIDM00225 | IST-MEL1 | None | 11.4967 |
| SIDM00337 | MEL-HO | None | 0.4113 |
| SIDM00336 | MEL-JUSO | None | 55.9726 |
| SIDM00545 | Mewo | None | 29.3341 |
| SIDM00401 | RVH-421 | None | 0.8579 |
| SIDM01079 | SH-4 | None | 0.5513 |
| SIDM01107 | SK-MEL-1 | None | 0.8179 |
| SIDM01105 | SK-MEL-3 | None | 4.8529 |
| SIDM01106 | SK-MEL-24 | None | 9.0433 |
| SIDM00392 | SK-MEL-30 | None | 33.9119 |
| SIDM01104 | SK-MEL-31 | None | 41.0719 |
| SIDM01000 | WM-115 | None | 0.9015 |
| SIDM01228 | CHL-1 | None | 6.5285 |
| SIDM01087 | RPMI-7951 | None | 9.7105 |
| SIDM00801 | A101D | None | 0.4653 |
| SIDM00543 | GAK | None | 45.0912 |
| SIDM01242 | MMAc-SF | None | 0.713 |
| SIDM00179 | MZ2-MEL | None | 5.9691 |
| SIDM00955 | COLO-783 | None | 6.6239 |
| SIDM00129 | G-MEL | None | 0.3347 |
| SIDM01066 | IGR-37 | None | 0.2481 |
| SIDM00975 | WM278 | None | 1.7926 |
| SIDM01240 | 451Lu | None | 0.214 |
| SIDM00663 | Hs-939-T | None | 2.3063 |
| SIDM00662 | Hs-940-T | None | 8.1323 |
| SIDM00126 | K2 | None | 5.4267 |
| SIDM00976 | WM1552C | None | 5.4418 |
| SIDM00974 | WM35 | None | 90.583 |
| SIDM00973 | WM793B | None | 10.4879 |
| SIDM00909 | COLO-829 | None | 6.9841 |
| SIDM00175 | CP50-MEL-B | None | 1.2104 |
| SIDM00190 | CP66-MEL | None | 7.9596 |
| SIDM00185 | LB2518-MEL | None | 129.312 |
| SIDM00184 | LB373-MEL-D | None | 202.8496 |
| SIDM00516 | MZ7-mel | None | 3.438 |
| SIDM00081 | SK-MEL-28 | None | 1.745 |
| SIDM00082 | SK-MEL-2 | None | 133.1928 |
| SIDM00080 | SK-MEL-5 | None | 3.8845 |
| SIDM00149 | LOXIMVI | None | 3.1281 |
| SIDM00003 | M14 | None | 0.8412 |
| SIDM00107 | UACC-62 | None | 0.6548 |
| SIDM00108 | UACC-257 | None | 1.2755 |
| SIDM00797 | A2058 | None | 17.6452 |
| SIDM00795 | A375 | None | 0.6834 |
| SIDM00515 | COLO-800 | None | 4.0953 |
| SIDM00140 | COLO-792 | None | 321.8424 |
| SIDM00284 | COLO-679 | None | 0.6227 |
| SIDM00890 | C32 | None | 1.0683 |
| SIDM00857 | G-361 | None | 3.2087 |
| SIDM00695 | HT-144 | None | 2.6006 |
| SIDM01060 | IGR-1 | None | 14.267 |
| SIDM01059 | IPC-298 | None | 14.1541 |
| SIDM00225 | IST-MEL1 | None | 11.0183 |
| SIDM00337 | MEL-HO | None | 0.6506 |
| SIDM00336 | MEL-JUSO | None | 60.9011 |
| SIDM00545 | Mewo | None | 226.8108 |
| SIDM00401 | RVH-421 | None | 3.681 |
| SIDM01079 | SH-4 | None | 0.4113 |
| SIDM01107 | SK-MEL-1 | None | 6.6069 |
| SIDM01105 | SK-MEL-3 | None | 4.163 |
| SIDM01106 | SK-MEL-24 | None | 3.2592 |
| SIDM00392 | SK-MEL-30 | None | 106.5127 |
| SIDM01104 | SK-MEL-31 | None | 44.0069 |
| SIDM01000 | WM-115 | None | 15.0547 |
| SIDM01228 | CHL-1 | None | 23.3244 |
| SIDM01087 | RPMI-7951 | None | 38.8484 |
| SIDM00801 | A101D | None | 2.8377 |
| SIDM00543 | GAK | None | 31.1037 |
| SIDM01242 | MMAc-SF | None | 0.4018 |
| SIDM00319 | VMRC-MELG | None | 92.1974 |
| SIDM00179 | MZ2-MEL | None | 1.2373 |
| SIDM00955 | COLO-783 | None | 4.0624 |
| SIDM00129 | G-MEL | None | 0.3479 |
| SIDM01066 | IGR-37 | None | 0.201 |
| SIDM00975 | WM278 | None | 9.7138 |
| SIDM01240 | 451Lu | None | 1.8329 |
| SIDM00663 | Hs-939-T | None | 5.0274 |
| SIDM00662 | Hs-940-T | None | 11.7795 |
| SIDM00126 | K2 | None | 0.9954 |
| SIDM00976 | WM1552C | None | 32.6095 |
| SIDM00974 | WM35 | None | 0.6485 |
| SIDM00973 | WM793B | None | 19.7206 |
| SIDM00909 | COLO-829 | None | 2.0444 |
| SIDM00190 | CP66-MEL | None | 75.7989 |
| SIDM00082 | SK-MEL-2 | None | 175.6888 |
| SIDM00080 | SK-MEL-5 | None | 18.3389 |
| SIDM00149 | LOXIMVI | None | 9.836 |