| Tag | Content |
|---|---|
| Uniprot ID | A0A0G2JU33 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSRNOP00000068945 |
| Ensembl nucleotide ID | ENSRNOG00000061603 |
| Gene name | Additional sex combs like 1 |
| Gene symbol | Asxl1 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | VLENYSDAPM TPKQILQVIE AEGLKEMSGT SPLACLNAML HSNSRGGEGL FYKLPGRISL 60 FTLKKDAVQW SRNVATLDGE EPEDSADVES CGSNEASTVS GENDVSLDET SSNASCATEP 120 QGRSLSNPRD GHRASSQANK QKKRTGVMLP RVVLTPLKVN GAHVEPASGF SGRHADGESG 180 SPSSSSSGSL ALGNSTIRSQ AEVTRDPAPL LRGFRKPATG QMKRNRGEEV DFETPGSILV 240 NTNLRALINS RTFHALPSHF QQQLLFLLPE VDRQVGTDGL LRLSSSALNN EFFTHAAQSW 300 RERLAEGEFT HEMQVRLRQE MEKEKKVEQW KEKFFEDYYG QKLGLTKEES LQQKEDQEEA 360 KIKSGLVSGE SVRPQRGPTR QRDGAFNRSR PDLRTRSRRN LYKKQEPEQA GIAKDANAAD 420 VSLSKDAKTD SPGVNSPPGP DVSSPASGQE GPKCPSEPVA SQIQTEMDNL ACASTSPDRT 480 PTLPQDSVDQ ETKDQKRKSF EQEASASFPE KKPLLEDRQS RNTIEVVART KKREPRRVSR 540 PHGRIQLSRI KPPWVAKGRP TYQICPRIVP ITESSCRGWT GARTLADIKA RALQARGARG 600 YHCNREAAAT AIGGGGGPGG GGSGAIDEGG GRDGSSGDGS EACGHSEPRG ASSNPGESAS 660 DLQRTQLLPS CPLNGEHTQA DAAMVRAKGE DSASLRKEEN GLLTRAPGVL TSGLEDASQP 720 PVAPTGDQPC QALPPLSSQT PVAEMLAEQA KLLPDDRTEC EPREDQGPTV PSEGSSGQSP 780 LGDILGGGND QIFDNMKEPV NMTPAFISEL SLANSLQDRP SDDELGVGAT GPHIRESRQE 840 TLKTEAFVSG SPGSWVPILS NYEVIKESYP EARENAPCLE PQDGKGWERT VPLVAAMPGG 900 HAEVLPYHES CASHWTAPPP GVLGSTCSDS QQVDLERLEM NGISDILSPH NESTDTASDS 960 EGHFSEDSSE VDACEITVVK GLLGGSEKQD WDPSASLSKA STDLSVLTRT EGVATPQSWV 1020 SRVCAVPHKI PDSLLLSSTE CQPRSVCPPK PGSSAEVTNP LVMHLLHGNL PLEKVLAPGH 1080 RSNQPESPHL PLREQNQDRG TLQGTGGDNH LVARSNPGSV QTLKESILAQ SYGASAGLVR 1140 AKASKAPGMS QKIARLVPSS DSQHPVTELT PSSSNLEEID SKEHLSSFLC EEQKEAHSLS 1200 QGSDPGAAPG QFLGDHTTSK VPCFSSTNVS LSFGSEQTDG TLSDQNDVGG REKKLFGPRN 1260 TVATLQYPRS EEQIPLPAEV PPVFPSRKIE PSKNSVPDGV QTARENRTPK PPAVSAGSIK 1320 TEQTFLRDPI KADAENRKAA GYSSLELVGH LQGMPFVVDL PFWKLPREPG KGFSQPLEPP 1380 SIPSQLSIKQ ALYGKFSKLQ LSPSSFNYSS SSAAFPRGLA GGVVQLSHKA SFGTGHTASL 1440 SLQMFTDSSA VESISLQCAC SLKAMIMCQG CGAFCHDDCI GPSKLCVLCL VVR 1493 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ASXL1 | A0A452G2F5 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | ASXL1 | 171023 | Q8IXJ9 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Asxl1 | 228790 | P59598 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | ASXL1 | H2R3B7 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | Asxl1 | A0A0G2JU33 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | asxl1 | F1RC47 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0035517 | PR-DUB complex |
| GO:0003682 | chromatin binding |
| GO:0003677 | DNA binding |
| GO:0042975 | peroxisome proliferator activated receptor binding |
| GO:0042974 | retinoic acid receptor binding |
| GO:0003713 | transcription coactivator activity |
| GO:0009887 | animal organ morphogenesis |
| GO:0048539 | bone marrow development |
| GO:0000902 | cell morphogenesis |
| GO:0072015 | glomerular visceral epithelial cell development |
| GO:0003007 | heart morphogenesis |
| GO:0030097 | hemopoiesis |
| GO:0048872 | homeostasis of number of cells |
| GO:0060430 | lung saccule development |
| GO:0035522 | monoubiquitinated histone H2A deubiquitination |
| GO:0045599 | negative regulation of fat cell differentiation |
| GO:0010888 | negative regulation of lipid storage |
| GO:0035359 | negative regulation of peroxisome proliferator activated receptor signaling pathway |
| GO:0048386 | positive regulation of retinoic acid receptor signaling pathway |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0035564 | regulation of kidney size |
| GO:0032526 | response to retinoic acid |
| GO:0048538 | thymus development |
| GO:0006351 | transcription, DNA-templated |
| Keyword ID | Keyword Term |
|---|---|
| KW-1185 | Reference proteome |