| Tag | Content |
|---|---|
| Uniprot ID | A0A287AHA8 |
| Entrez ID | |
| Genbank protein ID | HDA61558.1 |
| Genbank nucleotide ID | XM_013987639.1 |
| Ensembl protein ID | ENSSSCP00000043269 |
| Ensembl nucleotide ID | ENSSSCG00000035598 |
| Gene name | Endothelin-1 |
| Gene symbol | EDN1 |
| Organism | Sus scrofa |
| NCBI taxa ID | 9823 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MDYFPMIIAL LFVAFQGAPE TAVLGAELSP GAESQGETPS PHASWRPRRS KRCSCSSLMD 60 KECVYFCHLD IIWVNTPEHI VPYGLGSPSR SRRSLKDLFP AKAADRRDRC QCASQKDKKC 120 WSFCQAGKEI GRDQDTMEKR WDNQKKGTDC SKLGEKCIHR QLVMGRKIRR LEAISNSIKT 180 SFHIAKLKAE LYRDKKVTHN RTH 203 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
Protein disorder visualization from D2P2 is currently unavailable.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | EDN1 | 281137 | P17322 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | EDN1 | 403424 | P13206 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | EDN1 | 102175912 | A0A452E9X3 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | EDN1 | 100034060 | F7APB1 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | EDN1 | 1906 | P05305 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Edn1 | 13614 | P22387 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | EDN1 | 462437 | H2QSB1 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | EDN1 | A0A287AHA8 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | EDN1 | 100009270 | P29560 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Edn1 | 24323 | P22388 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005623 | cell |
| GO:0005737 | cytoplasm |
| GO:0005615 | extracellular space |
| GO:0005125 | cytokine activity |
| GO:0031707 | endothelin A receptor binding |
| GO:0031708 | endothelin B receptor binding |
| GO:0005179 | hormone activity |
| GO:0007193 | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| GO:0014824 | artery smooth muscle contraction |
| GO:0007589 | body fluid secretion |
| GO:0001569 | branching involved in blood vessel morphogenesis |
| GO:0019722 | calcium-mediated signaling |
| GO:0051216 | cartilage development |
| GO:0007166 | cell surface receptor signaling pathway |
| GO:0009953 | dorsal/ventral pattern formation |
| GO:0086100 | endothelin receptor signaling pathway |
| GO:0007507 | heart development |
| GO:0001701 | in utero embryonic development |
| GO:0048016 | inositol phosphate-mediated signaling |
| GO:0042474 | middle ear morphogenesis |
| GO:0032269 | negative regulation of cellular protein metabolic process |
| GO:0051771 | negative regulation of nitric-oxide synthase biosynthetic process |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0014032 | neural crest cell development |
| GO:0030185 | nitric oxide transport |
| GO:0030072 | peptide hormone secretion |
| GO:0014065 | phosphatidylinositol 3-kinase signaling |
| GO:0031583 | phospholipase D-activating G protein-coupled receptor signaling pathway |
| GO:0061051 | positive regulation of cell growth involved in cardiac muscle cell development |
| GO:0030335 | positive regulation of cell migration |
| GO:0045793 | positive regulation of cell size |
| GO:0051482 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway |
| GO:0051091 | positive regulation of DNA-binding transcription factor activity |
| GO:0010460 | positive regulation of heart rate |
| GO:0046887 | positive regulation of hormone secretion |
| GO:0043507 | positive regulation of JUN kinase activity |
| GO:0045840 | positive regulation of mitotic nuclear division |
| GO:0060585 | positive regulation of prostaglandin-endoperoxide synthase activity |
| GO:0010870 | positive regulation of receptor biosynthetic process |
| GO:0035815 | positive regulation of renal sodium excretion |
| GO:0060298 | positive regulation of sarcomere organization |
| GO:0048661 | positive regulation of smooth muscle cell proliferation |
| GO:0045987 | positive regulation of smooth muscle contraction |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0035810 | positive regulation of urine volume |
| GO:0001516 | prostaglandin biosynthetic process |
| GO:0042313 | protein kinase C deactivation |
| GO:0007205 | protein kinase C-activating G protein-coupled receptor signaling pathway |
| GO:0010827 | regulation of glucose transmembrane transport |
| GO:0006885 | regulation of pH |
| GO:0003100 | regulation of systemic arterial blood pressure by endothelin |
| GO:0019229 | regulation of vasoconstriction |
| GO:0007585 | respiratory gaseous exchange by respiratory system |
| GO:0001666 | response to hypoxia |
| GO:0043179 | rhythmic excitation |
| GO:0014826 | vein smooth muscle contraction |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00270 | ENDOTHELIN |
| Pfam ID | Pfam Term |
|---|---|
| PF00322 | Endothelin |