Gene: Edn1

Basic information

Tag Content
Uniprot ID P22388
Entrez ID 24323
Genbank protein ID AAA41129.1
Genbank nucleotide ID NM_012548.2; XM_017600453.1;
Ensembl protein ID ENSRNOP00000019361
Ensembl nucleotide ID ENSRNOG00000014361
Gene name Endothelin-1
Gene symbol Edn1
Organism Rattus norvegicus
NCBI taxa ID 10116
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity).
Sequence
MDYFPVIFSL LFVAFQGAPE TAVLGAELSP RAEKEVQSPP PSTSWRPRRS KRCSCSSLMD 60
KECVYFCHLD IIWVNTPERV VPYGLGSPSR SKRSLKDLLP TKTTDQGNRC QCAHQKDKKC 120
WNFCQADKEL RAQSTMQKGV KDFKKGKPCP KLGKKCIYQQ LVEGRKLRRL EAISNSIKTS 180
FRVAKLKAEL YRDQKLIHNR AH 202

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Protein disorder visualization from D2P2 is currently unavailable.

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologEDN1281137P17322Bos taurusPredictionMore>>
1:1 orthologEDN1403424P13206Canis lupus familiarisPredictionMore>>
1:1 orthologEDN1102175912A0A452E9X3Capra hircusPredictionMore>>
1:1 orthologEDN1100034060F7APB1Equus caballusPredictionMore>>
1:1 orthologEDN11906P05305Homo sapiensPredictionMore>>
1:1 orthologEdn113614P22387CPOMus musculusPublicationMore>>
1:1 orthologEDN1462437H2QSB1Pan troglodytesPredictionMore>>
1:1 orthologEDN1A0A287AHA8Sus scrofaPredictionMore>>
1:1 orthologEDN1100009270P29560Oryctolagus cuniculusPredictionMore>>
1:1 orthologEdn124323P22388Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0045178 basal part of cell
GO:0005623 cell
GO:0005737 cytoplasm
GO:0005615 extracellular space
GO:0048237 rough endoplasmic reticulum lumen
GO:0033093 Weibel-Palade body
GO:0005125 cytokine activity
GO:0031707 endothelin A receptor binding
GO:0031708 endothelin B receptor binding
GO:0005179 hormone activity
GO:0005102 signaling receptor binding
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO:0014824 artery smooth muscle contraction
GO:0048514 blood vessel morphogenesis
GO:0007589 body fluid secretion
GO:0001569 branching involved in blood vessel morphogenesis
GO:0019722 calcium-mediated signaling
GO:0051216 cartilage development
GO:0007166 cell surface receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0071277 cellular response to calcium ion
GO:0035690 cellular response to drug
GO:0071398 cellular response to fatty acid
GO:0071385 cellular response to glucocorticoid stimulus
GO:0071456 cellular response to hypoxia
GO:0071346 cellular response to interferon-gamma
GO:0071347 cellular response to interleukin-1
GO:0071389 cellular response to mineralocorticoid stimulus
GO:0071375 cellular response to peptide hormone stimulus
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0071356 cellular response to tumor necrosis factor
GO:0009953 dorsal/ventral pattern formation
GO:0086100 endothelin receptor signaling pathway
GO:0042045 epithelial fluid transport
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007507 heart development
GO:0001821 histamine secretion
GO:0001701 in utero embryonic development
GO:0048016 inositol phosphate-mediated signaling
GO:0035556 intracellular signal transduction
GO:0060137 maternal process involved in parturition
GO:0051899 membrane depolarization
GO:0042474 middle ear morphogenesis
GO:0010259 multicellular organism aging
GO:0032269 negative regulation of cellular protein metabolic process
GO:0010629 negative regulation of gene expression
GO:0046888 negative regulation of hormone secretion
GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process
GO:0034392 negative regulation of smooth muscle cell apoptotic process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0014032 neural crest cell development
GO:0030185 nitric oxide transport
GO:0030072 peptide hormone secretion
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0031583 phospholipase D-activating G protein-coupled receptor signaling pathway
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development
GO:0030335 positive regulation of cell migration
GO:0008284 positive regulation of cell population proliferation
GO:0045793 positive regulation of cell size
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0010460 positive regulation of heart rate
GO:0046887 positive regulation of hormone secretion
GO:0043507 positive regulation of JUN kinase activity
GO:0043406 positive regulation of MAP kinase activity
GO:0045840 positive regulation of mitotic nuclear division
GO:0090023 positive regulation of neutrophil chemotaxis
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:0042482 positive regulation of odontogenesis
GO:0032308 positive regulation of prostaglandin secretion
GO:0060585 positive regulation of prostaglandin-endoperoxide synthase activity
GO:0010870 positive regulation of receptor biosynthetic process
GO:0035815 positive regulation of renal sodium excretion
GO:0060298 positive regulation of sarcomere organization
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0045987 positive regulation of smooth muscle contraction
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0035810 positive regulation of urine volume
GO:1904707 positive regulation of vascular smooth muscle cell proliferation
GO:0001516 prostaglandin biosynthetic process
GO:0042313 protein kinase C deactivation
GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway
GO:0008217 regulation of blood pressure
GO:0010827 regulation of glucose transmembrane transport
GO:0006885 regulation of pH
GO:0051930 regulation of sensory perception of pain
GO:0003100 regulation of systemic arterial blood pressure by endothelin
GO:0019229 regulation of vasoconstriction
GO:0007585 respiratory gaseous exchange by respiratory system
GO:0014823 response to activity
GO:0043200 response to amino acid
GO:0071548 response to dexamethasone
GO:0042493 response to drug
GO:0001666 response to hypoxia
GO:0044321 response to leptin
GO:0032496 response to lipopolysaccharide
GO:0035994 response to muscle stretch
GO:0035094 response to nicotine
GO:0010193 response to ozone
GO:0034696 response to prostaglandin F
GO:1902074 response to salt
GO:0033574 response to testosterone
GO:0071559 response to transforming growth factor beta
GO:0043179 rhythmic excitation
GO:0019233 sensory perception of pain
GO:0001501 skeletal system development
GO:0042554 superoxide anion generation
GO:0042310 vasoconstriction
GO:0014826 vein smooth muscle contraction

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0002 3D-structure
KW-0165 Cleavage on pair of basic residues
KW-1015 Disulfide bond
KW-1185 Reference proteome
KW-0964 Secreted
KW-0732 Signal
KW-0838 Vasoactive
KW-0839 Vasoconstrictor

Interpro

InterPro ID InterPro Term
IPR020475 Endothelin
IPR019764 Endothelin_toxin_CS
IPR001928 Endothln-like_toxin

PROSITE

PROSITE ID PROSITE Term
PS00270 ENDOTHELIN

Pfam

Pfam ID Pfam Term
PF00322 Endothelin