| Tag | Content |
|---|---|
| Uniprot ID | A0A2I3RMA9; A0A2J8N7P6; |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSPTRP00000065828 |
| Ensembl nucleotide ID | ENSPTRG00000020176 |
| Gene name | Fibroblast growth factor receptor |
| Gene symbol | FGFR1 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MEARVSLKRR IELTVEYPWR CGALSPTSNC RTGMWSWKCL LFWAVLVTAT LCTARPSPTL 60 PEQAQPWGAP VEVESFLVHP GDLLQLRCRL RDDVQSINWL RDGVQLAESN RTRITGEEVE 120 VQDSVPADSG LYACVTSSPS GSDTTYFSVN VSDALPSSED DDDDDDDSSS EEKETDNTKP 180 NPVAPYWTSP EKMEKKLHAV PAAKTVKFKC PSSGTPNPTL RWLKNGKEFK PDHRIGGYKV 240 RYATWSIIMD SVVPSDKGNY TCIVENEYGS INHTYQLDVV ERSPHRPILQ AGLPANKTVA 300 LGSNVEFMCK VYSDPQPHIQ WLKHIEVNGS KIGPDNLPYV QILKTAGVNT TDKEMEVLHL 360 RNVSFEDAGE YTCLAGNSIG LSHHSAWLTV LEALEERPAV MTSPLYLEII IYCTGAFLIS 420 CMVGSVIVYK MKSGTKKSDF HSQMAVHKLA KSIPLRRQVT VSADSSASMN SGVLLVRPSR 480 LSSSGTPMLA GVSEYELPED PRWELPRDRL VLGKPLGEGC FGQVVLAEAI GLDKDKPNRV 540 TKVAVKMLKS DATEKDLSDL ISEMEMMKMI GKHKNIINLL GACTQDGPLY VIVEYASKGN 600 LREYLQARRP PGLEYCYNPS HNPEEQLSSK DLVSCAYQVA RGMEYLASKK CIHRDLAARN 660 VLVTEDNVMK IADFGLARDI HHIDYYKKTT NGRLPVKWMA PEALFDRIYT HQSDVWSFGV 720 LLWEIFTLGG SPYPGVPVEE LFKLLKEGHR MDKPSNCTNE LYMMMRDCWH AVPSQRPTFK 780 QLVEDLDRIV ALTSNQEYLD LSMPLDQYSP SFPDTRSSTC SSGEDSVFSH EPLPEEPCLP 840 RHPAQLANGG LKRR 854 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | FGFR1 | 281768 | A4IFL5 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | FGFR1 | 100856477 | A0A5F4CQJ1 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | FGFR1 | A0A452E6I8 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | FGFR1 | 2260 | P11362 | CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Fgfr1 | 14182 | P16092 | CPO | E14.5, E16.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | FGFR1 | A0A2I3RMA9 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | Fgfr1 | F1LM54 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | fgfr1b | F1Q5T3 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005887 | integral component of plasma membrane |
| GO:0043235 | receptor complex |
| GO:0005524 | ATP binding |
| GO:0017134 | fibroblast growth factor binding |
| GO:0005007 | fibroblast growth factor-activated receptor activity |
| GO:0008201 | heparin binding |
| GO:0042803 | protein homodimerization activity |
| GO:0090722 | receptor-receptor interaction |
| GO:0042169 | SH2 domain binding |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| GO:0001525 | angiogenesis |
| GO:0060117 | auditory receptor cell development |
| GO:0060445 | branching involved in salivary gland morphogenesis |
| GO:0048469 | cell maturation |
| GO:0002062 | chondrocyte differentiation |
| GO:0030326 | embryonic limb morphogenesis |
| GO:0035607 | fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development |
| GO:0001701 | in utero embryonic development |
| GO:0042472 | inner ear morphogenesis |
| GO:0060484 | lung-associated mesenchyme development |
| GO:0048762 | mesenchymal cell differentiation |
| GO:0030901 | midbrain development |
| GO:0042474 | middle ear morphogenesis |
| GO:0007275 | multicellular organism development |
| GO:0090272 | negative regulation of fibroblast growth factor production |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0001759 | organ induction |
| GO:0042473 | outer ear morphogenesis |
| GO:0048339 | paraxial mesoderm development |
| GO:0043536 | positive regulation of blood vessel endothelial cell migration |
| GO:0060045 | positive regulation of cardiac muscle cell proliferation |
| GO:0045597 | positive regulation of cell differentiation |
| GO:2000546 | positive regulation of endothelial cell chemotaxis to fibroblast growth factor |
| GO:0033674 | positive regulation of kinase activity |
| GO:0043406 | positive regulation of MAP kinase activity |
| GO:0090080 | positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway |
| GO:0002053 | positive regulation of mesenchymal cell proliferation |
| GO:1903465 | positive regulation of mitotic cell cycle DNA replication |
| GO:0010976 | positive regulation of neuron projection development |
| GO:2000830 | positive regulation of parathyroid hormone secretion |
| GO:0010863 | positive regulation of phospholipase C activity |
| GO:1905564 | positive regulation of vascular endothelial cell proliferation |
| GO:0046777 | protein autophosphorylation |
| GO:0060665 | regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling |
| GO:2001239 | regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| GO:0048378 | regulation of lateral mesodermal cell fate specification |
| GO:0010966 | regulation of phosphate transport |
| GO:0007605 | sensory perception of sound |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| GO:0001657 | ureteric bud development |
| GO:0021847 | ventricular zone neuroblast division |
| GO:0070640 | vitamin D3 metabolic process |
| Keyword ID | Keyword Term |
|---|---|
| KW-0067 | ATP-binding |
| KW-1015 | Disulfide bond |
| KW-0393 | Immunoglobulin domain |
| KW-0418 | Kinase |
| KW-0472 | Membrane |
| KW-0547 | Nucleotide-binding |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0808 | Transferase |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0829 | Tyrosine-protein kinase |
| InterPro ID | InterPro Term |
|---|---|
| IPR028174 | FGF_rcpt_1 |
| IPR016248 | FGF_rcpt_fam |
| IPR041159 | FGFR_TM |
| IPR007110 | Ig-like_dom |
| IPR036179 | Ig-like_dom_sf |
| IPR013783 | Ig-like_fold |
| IPR013098 | Ig_I-set |
| IPR003599 | Ig_sub |
| IPR003598 | Ig_sub2 |
| IPR013151 | Immunoglobulin |
| IPR011009 | Kinase-like_dom_sf |
| IPR000719 | Prot_kinase_dom |
| IPR017441 | Protein_kinase_ATP_BS |
| IPR001245 | Ser-Thr/Tyr_kinase_cat_dom |
| IPR008266 | Tyr_kinase_AS |
| IPR020635 | Tyr_kinase_cat_dom |