| Tag | Content |
|---|---|
| Uniprot ID | A0A452E6I8 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSCHIP00000007607 |
| Ensembl nucleotide ID | ENSCHIG00000011006 |
| Gene name | Fibroblast growth factor receptor |
| Gene symbol | FGFR1 |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MWSRKCLLFW AVLVTATLCT AKPAPTLPEQ AQPWGAPVEV ESLLVHPGDL LQLRCRLRDD 60 VQSINWLRDG VQLADSNRTR ITGEEVEVRG SVPADSGLYA CVTSSPSGSD TTYFSVNVSD 120 ALPSSEDDDD DDDSSSEEKE TDNTKPNPVA PYWTSPEKME KKLHAVPAAK TVKFKCPSSG 180 TPNPTLRWLK NGKEFKPDHR IGGYKVRYAT WSIIMDSVVP SDKGNYTCIV ENEYGSINHT 240 YQLDVVERSP HRPILQAGLP ANKTVALGSN VEFMCKVYSD PQPHIQWLKH IEVNGSKIGP 300 DNLPYVQILK TAGVNTTDKE MEVLHLRNVS FEDAGEYTCL AGNSIGLSHH SAWLTVLEVP 360 LDARRCGLQT WMRCHLGPRG TPGPSVMEDR RIVRCPMIAL EERPAVMTSP LYLEIIIYCT 420 GAFLISCMVG SVIIYKMKSG TKKSDFHSQM AVHKLAKSIP LRRQVTVSAD SSASMNSGVL 480 LVRPSRLSSS GTPMLAGVSE YELPEDPRWE LPRDRLVLGK PLGEGCFGQV VLAEAIGLDK 540 DKPNRVTKVA VKMLKADATE KDLSDLISEM EMMKMIGKHK NIINLLGACT QDGPLYVIVE 600 YASKGNLREY LQARRPPGLE YCYNPSHHPE EQLSSKDLVS CAYQVARGME YLASKKCIHR 660 DLAARNVLVT EDNVMKIADF GLARDIHHID YYKKTTNGRL PVKWMAPEAL FDRIYTHQSD 720 VWSFGVLLWE IFTLGGSPYP GVPVEELFKL LKEGHRMDKP SNCTNELYMM MRDCWHAVPS 780 QRPTFKQLVE DLDRIVALTS NQEYLDLSMP LDQYSPSFPD TRSSTCSSGE DSVFSHEPLP 840 EEPCLPRHPA QLANGGLKRR |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | FGFR1 | 281768 | A4IFL5 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | FGFR1 | 100856477 | A0A5F4CQJ1 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | FGFR1 | A0A452E6I8 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | FGFR1 | 2260 | P11362 | CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Fgfr1 | 14182 | P16092 | CPO | E14.5, E16.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | FGFR1 | A0A2I3RMA9 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | Fgfr1 | F1LM54 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | fgfr1b | F1Q5T3 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0016021 | integral component of membrane |
| GO:0005886 | plasma membrane |
| GO:0043235 | receptor complex |
| GO:0005524 | ATP binding |
| GO:0017134 | fibroblast growth factor binding |
| GO:0005007 | fibroblast growth factor-activated receptor activity |
| GO:0008201 | heparin binding |
| GO:0042803 | protein homodimerization activity |
| GO:0090722 | receptor-receptor interaction |
| GO:0042169 | SH2 domain binding |
| GO:0001525 | angiogenesis |
| GO:0060117 | auditory receptor cell development |
| GO:0060445 | branching involved in salivary gland morphogenesis |
| GO:0048469 | cell maturation |
| GO:0002062 | chondrocyte differentiation |
| GO:0030326 | embryonic limb morphogenesis |
| GO:0035607 | fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development |
| GO:0001701 | in utero embryonic development |
| GO:0042472 | inner ear morphogenesis |
| GO:0060484 | lung-associated mesenchyme development |
| GO:0048762 | mesenchymal cell differentiation |
| GO:0030901 | midbrain development |
| GO:0042474 | middle ear morphogenesis |
| GO:0090272 | negative regulation of fibroblast growth factor production |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0001759 | organ induction |
| GO:0042473 | outer ear morphogenesis |
| GO:0048339 | paraxial mesoderm development |
| GO:0043536 | positive regulation of blood vessel endothelial cell migration |
| GO:0060045 | positive regulation of cardiac muscle cell proliferation |
| GO:2000546 | positive regulation of endothelial cell chemotaxis to fibroblast growth factor |
| GO:0043406 | positive regulation of MAP kinase activity |
| GO:0090080 | positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway |
| GO:0002053 | positive regulation of mesenchymal cell proliferation |
| GO:1903465 | positive regulation of mitotic cell cycle DNA replication |
| GO:0010976 | positive regulation of neuron projection development |
| GO:2000830 | positive regulation of parathyroid hormone secretion |
| GO:0010863 | positive regulation of phospholipase C activity |
| GO:1905564 | positive regulation of vascular endothelial cell proliferation |
| GO:0046777 | protein autophosphorylation |
| GO:0060665 | regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling |
| GO:2001239 | regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| GO:0048378 | regulation of lateral mesodermal cell fate specification |
| GO:0010966 | regulation of phosphate transport |
| GO:0007605 | sensory perception of sound |
| GO:0001657 | ureteric bud development |
| GO:0021847 | ventricular zone neuroblast division |
| GO:0070640 | vitamin D3 metabolic process |
| Keyword ID | Keyword Term |
|---|---|
| KW-0067 | ATP-binding |
| KW-1015 | Disulfide bond |
| KW-0393 | Immunoglobulin domain |
| KW-0418 | Kinase |
| KW-0472 | Membrane |
| KW-0547 | Nucleotide-binding |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0732 | Signal |
| KW-0808 | Transferase |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0829 | Tyrosine-protein kinase |
| InterPro ID | InterPro Term |
|---|---|
| IPR028174 | FGF_rcpt_1 |
| IPR016248 | FGF_rcpt_fam |
| IPR041159 | FGFR_TM |
| IPR007110 | Ig-like_dom |
| IPR036179 | Ig-like_dom_sf |
| IPR013783 | Ig-like_fold |
| IPR013098 | Ig_I-set |
| IPR003599 | Ig_sub |
| IPR003598 | Ig_sub2 |
| IPR013151 | Immunoglobulin |
| IPR011009 | Kinase-like_dom_sf |
| IPR000719 | Prot_kinase_dom |
| IPR017441 | Protein_kinase_ATP_BS |
| IPR001245 | Ser-Thr/Tyr_kinase_cat_dom |
| IPR008266 | Tyr_kinase_AS |
| IPR020635 | Tyr_kinase_cat_dom |