| Tag | Content |
|---|---|
| Uniprot ID | A0A3Q1M8J1 |
| Entrez ID | 497032 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_015475084.1 |
| Ensembl protein ID | ENSBTAP00000066765; ENSBTAP00000059159; |
| Ensembl nucleotide ID | ENSBTAG00000020698 |
| Gene name | Methylenetetrahydrofolate reductase |
| Gene symbol | MTHFR |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MVNEPRGNGS PGPRWEGSSS GSESSKDSSR CSTPGLDPER CERLREKMKR RMDSGDKWFS 60 LEFFPPRTAQ GAVNLISRFD RMGAGGPLFV DVTWHPAGDP GSDKETSSMV IASTAVNYCG 120 LETILHMTCC HQSREEITGH LNKAKQLGLK NILALRGDPI GDQWEEEEGG FNYATDLVKH 180 IRNEFGDYFD VCVAGYPKGH PEGESFEADL KHLKEKVAAG ADFIITQLFF EAETFFRFVK 240 ACSEIGITCP ILPGIFPIQG YHSLRQLVKL SKLEVPQQIK DVIEPIKDND AAIRNYGIEQ 300 AVSLCQELLA SGLVPGLHFY TLNREVATIE VLKRLGLWIE DPRRPLPWAL SAHPKRRVED 360 VRPIFWASRP KSYIYRTQEW DEFPNGRWGN SSSPAFGELK DYYLFYLKSK SPKEELLKMW 420 GEELTSEESV FQVFAHYLSG EPNQNGYKVT CLPWNDEPLA AETSLMKEEL LRVNRRGILT 480 INSQPNINGK PSSDPIVGWG PSGGYVFQKA YLEFFTSRET VEALLQVLKK YELRVNYHIV 540 DVKGENITNA PELQPNAVTW GIFPGREIIQ PTVVDPVSFM FWKDEAFALW IEQWGKLYEE 600 ESPSRMIIQY IHDNYFLVNL VDNEFPLDNC LWQVVEDTFE LLSRPPQDKR ETEAL 655 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MTHFR | 497032 | A0A3Q1M8J1 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | MTHFR | E2QXW9 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | MTHFR | 102182523 | A0A452G4N1 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | MTHFR | A0A3Q2HUW6 | Equus caballus | Prediction | More>> | |||
| 1:1 ortholog | MTHFR | 4524 | P42898 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Mthfr | A2A7F9 | Mus musculus | Prediction | More>> | |||
| 1:1 ortholog | MTHFR | 469800 | H2PY11 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | 397180 | F1RF82 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Mthfr | 362657 | D4A7E8 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | mthfr | 567547 | B0V153 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0004489 | methylenetetrahydrofolate reductase (NAD(P)H) activity |
| GO:0006555 | methionine metabolic process |
| GO:0035999 | tetrahydrofolate interconversion |
| Pfam ID | Pfam Term |
|---|---|
| PF02219 | MTHFR |