| Tag | Content |
|---|---|
| Uniprot ID | E2QXW9 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSCAFP00000024357 |
| Ensembl nucleotide ID | ENSCAFG00000016558 |
| Gene name | Methylenetetrahydrofolate reductase |
| Gene symbol | MTHFR |
| Organism | Canis lupus familiaris |
| NCBI taxa ID | 9615 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MDQPPPGVLP ATVRCSRLGL WTLEAGRVGF SVPPSISRSP AMVKEPRGDG DGGPTPRSEG 60 SSSGSESSKD SSRCSTPGLD PERHERLREK MRRRMESGDR WFSLEFFPPR TAEGAVNLIS 120 RFDRMGAGGP LFIDVTWHPA GDPGSDKETS SMMIASTAVN YCGLETILHM TCCCQSREQI 180 TGYLHKAKRL GLKNILALRG XXVGDQWEVV EGGFSYAADL VRHIRSEFGD YFDICVAGYP 240 KGHPDAGSFE ADLKYLKEKV SAGADFIITQ LFFEADTFFH FVKACSEIGI TCPILPGIFP 300 IQGYHSLRQL VKLSKLEVPQ QIKDVIEPIK DNDAAIRNYG IEQAVSLCQE LLTSGLVPGL 360 HFYTLNREMA TTEVLKRLGM WIEDPRRPLP WAVSAHPKRR EEDVRPIFWA SRPKSYIYRT 420 QEWDEFPNGR WGNSSSPAFG ELKDYYLFYL KSKSPREELL KMWGEELTSE ESVFEVFARY 480 LSGEPNQHGY KVTCLPWNDE PLAAETSLMK EELLRVNRQG ILTINSQPNI NGKPSSDPIV 540 GWGPSGGYVF QKAYLEFFTS RETVGALLQV LKKYELRVNY HIVDVKGENI TNAPELQPNA 600 VTWGIFPGRE IIQPTVVDPV SFMFWKDEAF ALWIEQWGKL YEEESPSRMI IQYIHDNYFL 660 VNLVDNEFPL DNCLWQVVED TFELLKGPSP EREAEAV 697 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MTHFR | 497032 | A0A3Q1M8J1 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | MTHFR | E2QXW9 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | MTHFR | 102182523 | A0A452G4N1 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | MTHFR | A0A3Q2HUW6 | Equus caballus | Prediction | More>> | |||
| 1:1 ortholog | MTHFR | 4524 | P42898 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Mthfr | A2A7F9 | Mus musculus | Prediction | More>> | |||
| 1:1 ortholog | MTHFR | 469800 | H2PY11 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | 397180 | F1RF82 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Mthfr | 362657 | D4A7E8 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | mthfr | 567547 | B0V153 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005829 | cytosol |
| GO:0071949 | FAD binding |
| GO:0004489 | methylenetetrahydrofolate reductase (NAD(P)H) activity |
| GO:0009086 | methionine biosynthetic process |
| GO:0006730 | one-carbon metabolic process |
| GO:0035999 | tetrahydrofolate interconversion |
| Pfam ID | Pfam Term |
|---|---|
| PF02219 | MTHFR |