Gene:

Basic information

Tag Content
Uniprot ID F1RF82
Entrez ID 397180
Genbank protein ID HDC06129.1; HDC66202.1; HDC23424.1; HDC05138.1; HDC01370.1; HDC12757.1; HDC08735.1; HDC02839.1; HDC49696.1; HDC01371.1; HDC23425.1; HDC04044.1; HDC23423.1; HDC48643.1; HDC23427.1; HDC11104.1; HDC01369.1; HDC11105.1; HDC23422.1;
Genbank nucleotide ID XM_003127574.3; XM_005664996.2; XM_005664995.2;
Ensembl protein ID
Ensembl nucleotide ID
Gene name Methylenetetrahydrofolate reductase
Gene symbol
Organism Sus scrofa
NCBI taxa ID 9823
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MVNEPRGNGG PGPRCEGSSS GSESSKESSR CSTPGLDPER HERLREKMKR RMESGDKWFS 60
LEFFPPRTAQ GAVNLISRFD RMGAGGPLFI DVTWHPAGDP GSDKETSSMV IASTAVNYCG 120
LETILHMTCC HQSREEVTGY LHKAKRLGLK NILALRGDPV GDQWEAEEGG FSYAADLVKH 180
IRSEFGDYFD VCVAGYPKGH PDAESFEADL KHLKEKVAAG ADFIITQLFF EADTFFRFLK 240
ACSEMGITCP ILPGIFPIQG YHSLRQLVKL SKLEVPQQIK DVIEPIKDND AAIRNYGIEQ 300
AVSLCQELLA SGLVPGLHFY TLNREVATTE VLKRLGLWIE DPRRPLPWAV SAHPKRREED 360
VRPIFWASRP KSYIYRTQEW DEFPNGRWGN SSSPAFGELK DYYLFYLKSK SPKEELLKMW 420
GQELTSEESV FEVFAHYLSG EPNQNGYKVT CLPWNDEPLA AETSLMKEEL LRVNRRGILT 480
INSQPNINGK PSSDPVVGWG PSGGYVFQKA YLEFFTARET VEALLQVLKK YELRVNYHIV 540
DVKGENITNA PELQPNAVTW GIFPGREIIQ PTVVDPVSFM FWKDEAFALW IEQWGKLYEE 600
ESPSRMLIQY IHDNYFLVNL VDNEFPLDNC LWQVVEDTFE LLNRPPHNEK EPEASDPAP 659

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologMTHFR497032A0A3Q1M8J1Bos taurusPredictionMore>>
1:1 orthologMTHFRE2QXW9Canis lupus familiarisPredictionMore>>
1:1 orthologMTHFR102182523A0A452G4N1Capra hircusPredictionMore>>
1:1 orthologMTHFRA0A3Q2HUW6Equus caballusPredictionMore>>
1:1 orthologMTHFR4524P42898CPO,CL/PHomo sapiensPublicationMore>>
1:1 orthologMthfrA2A7F9Mus musculusPredictionMore>>
1:1 orthologMTHFR469800H2PY11Pan troglodytesPredictionMore>>
1:1 ortholog397180F1RF82Sus scrofaPredictionMore>>
1:1 orthologMthfr362657D4A7E8Rattus norvegicusPredictionMore>>
1:1 orthologmthfr567547B0V153Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0050660 flavin adenine dinucleotide binding
GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity
GO:0072341 modified amino acid binding
GO:0044877 protein-containing complex binding
GO:0070829 heterochromatin maintenance
GO:0050667 homocysteine metabolic process
GO:0006555 methionine metabolic process
GO:0001843 neural tube closure
GO:0031060 regulation of histone methylation
GO:0035999 tetrahydrofolate interconversion

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0274 FAD
KW-0285 Flavoprotein
KW-0560 Oxidoreductase

Interpro

InterPro ID InterPro Term
IPR029041 FAD-linked_oxidoreductase-like
IPR004621 Fadh2_euk
IPR003171 Mehydrof_redctse

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF02219 MTHFR