| Tag | Content |
|---|---|
| Uniprot ID | A0A452E942 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSCHIP00000008464 |
| Ensembl nucleotide ID | ENSCHIG00000011642 |
| Gene name | c-SKI_SMAD_bind domain-containing protein |
| Gene symbol | SKOR2 |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MASSPLPGPN DILLASPSSA FQPDALSQPR PGHANLKPNQ VGQVILYGIP IVSLVIDGQE 60 RLCLAQISNT LLKNFSYNEI HNRRVALGIT CVQCTPVQLE ILRRAGAMPI SSRRCGMITK 120 REAERLCKSF LGENRPPKLP DNFAFDVSHE CAWGCRGSFI PARYNSSRAK CIKCSYCNMY 180 FSPNKFIFHS HRTPDAKYTQ PDAANFNSWR RHLKLTDKSP QDELVFAWED VKAMFNGGSR 240 KRALPQPGAH PACHPLSSVK AAAVAAAAAV AGGGGLLGPH LLGAPPPPPP PPPLAELAGA 300 PHAPHHKRPR FEDDDDSLQE AAVVAAASLS AAAAASLSAA AASGGAGAAG GGAGGGCVTG 360 AGAAAGAKGP RSYPVIPVPS KGSFGGVLQK FPGCGGLFPH PYTFPAAAAA FGLCHKKEDA 420 GAAAEALGGA GGAGAAPKAG LSGLFWPAGR KDAFYPPFCM FWPPRTPGGL PVPTYLQPPP 480 QPPSALGCAL GESPALLRQA FLDLAEPGGA GAGPGAEAAP PPGQPPPVVA NGPGSGQPPP 540 AGGAGARDAL FESPPGGGGG DCSAGSTPPA DPGSVTGAAG AGPAGARGPA APHPHLLEGR 600 KAGGGSYHHS SAFRPVGGKD DAESLAKLHG ASAAHHHHHH HHPPHQHHHH HHHHHPPQPP 660 SPPLLLLPPQ PDEPGSERHH AAPPPPPPPP PPLAPQPHPR GLLSPGGTSC SYPSEDSSED 720 EDDEEEEQEV DVEGHKPPEG EEEEDEGREP EDDEEEDEET GVLLADPLVG GGRFLQGRGL 780 SEKGSSRDRP PAAAGAFPLA LSSSRLLQED GKLGDPGGPD LPPPPPPPLA SQTQSGGLGS 840 SPGSPVHHPS LEEQPSYKDV NIPFRSLVDF VFCLILDKNK EHSFFITDSD ASGDFWRERA 900 GEHTQETNSP HSLKKDVENM GKEELQKVLF EQIDLRRRLE QEFQVLKGNT SFPVFNNFQD 960 QMKRELAYRE EMVQQLQIIP YAASLIRKEK LGAHLSKS 998 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SKOR2 | A0A452E942 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | SKOR2 | 652991 | Q2VWA4 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Skor2 | 664805 | A7M7C7 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | SKOR2 | A0A2I3S940 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | Skor2 | D3ZAH4 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005634 | nucleus |
| GO:0003682 | chromatin binding |
| GO:0042826 | histone deacetylase binding |
| GO:0046332 | SMAD binding |
| GO:0003714 | transcription corepressor activity |
| GO:0048468 | cell development |
| GO:0021702 | cerebellar Purkinje cell differentiation |
| GO:0030514 | negative regulation of BMP signaling pathway |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway |
| GO:0045880 | positive regulation of smoothened signaling pathway |
| GO:0021936 | regulation of cerebellar granule cell precursor proliferation |
| GO:0048814 | regulation of dendrite morphogenesis |