| Tag | Content |
|---|---|
| Uniprot ID | A7M7C7 |
| Entrez ID | 664805 |
| Genbank protein ID | BAF76044.1 |
| Genbank nucleotide ID | NM_001109743.1; XM_006526436.3; |
| Ensembl protein ID | ENSMUSP00000132338 |
| Ensembl nucleotide ID | ENSMUSG00000091519 |
| Gene name | SKI family transcriptional corepressor 2 |
| Gene symbol | Skor2 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 21937600 |
| Functional description | Acts as a TGF-beta antagonist in the nervous system (By similarity). Exhibits transcriptional repressor activity. |
| Sequence | MASSPLPGPN DILLASPSSA FQPDALSQPR PGHANLKPNQ VGQVILYGIP IVSLVIDGQE 60 RLCLAQISNT LLKNFSYNEI HNRRVALGIT CVQCTPVQLE ILRRAGAMPI SSRRCGMITK 120 REAERLCKSF LGENRPPKLP DNFAFDVSHE CAWGCRGSFI PARYNSSRAK CIKCSYCNMY 180 FSPNKFIFHS HRTPDAKYTQ PDAANFNSWR RHLKLTDKSP QDELVFAWED VKAMFNGGSR 240 KRALPQPSAH PACHPLSSVK AAAVAAAAAV AGGGGLLGPH LLGAPPPPPP PPPLAELAGA 300 PHAHHKRPRF DDDDDSLQEA AVVAAASLSA AAASLSVAAA TGGAGPGAGG PGGGCVAGVG 360 VGASAGAGAA AGTKGPRSYP VIPVPSKGSF GGVLQKFPGC GGLFPHPYTF PAAAAAFGLC 420 HKKEDAGTAA EALGGAGAGS AGAAPKAGLS GLFWPAGRKD AFYPPFCMFW PPRTPGGLPV 480 PTYLQPPPQP PSALGCALGD SPALLRQAFL DLAEPGGAGG SAEAAPPPGQ PPPVVANGPG 540 SGPPATGGTG ARDTLFESPP GGSGGDCSAG STPPAEQGVT SGTGSASSGA GSVGTRVPAP 600 HHPHLLEGRK AGGGSYHHSS AFRPVGGKDD AESLAKLHGA SAGTPHSAPA HHHHHHHHPH 660 HHHHHPPQPP SPLLLLQPQP DEPGSERHHP APPPPPPPPP LAPQPHHRGL LSPEGTSCSY 720 PSEDSSEDEE DEEEEQEVDV EGHKPLEGEE EEDGRDPEDE EEEDEETRVL LGDSLVGGGR 780 FLQGRGLSEK GSGRDRTTPA VGAFPLALNS SRLLQEDGKL GDSGGSDLPA PPPPPLAPQK 840 ASSSGGSRPG SPVHHPSLEE EPSYKDNQKP KENNQVIIST KDDNFSDKNK GHGFFITDSD 900 SSGDFWRERS GEHTQETNSP HSLKKDVENM GKEELQKVLF EQIDLRRRLE QEFQVLKGNT 960 SFPVFNNFQD QMKRELAYRE EMVQQLQIIP YAASLIRKEK LGAHLSKS 1008 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SKOR2 | A0A452E942 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | SKOR2 | 652991 | Q2VWA4 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Skor2 | 664805 | A7M7C7 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | SKOR2 | A0A2I3S940 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | Skor2 | D3ZAH4 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0003682 | chromatin binding | IDA |
| GO:0003714 | transcription corepressor activity | IDA |
| GO:0003714 | transcription corepressor activity | IBA |
| GO:0042826 | histone deacetylase binding | IPI |
| GO:0046332 | SMAD binding | ISO |
| GO:0046332 | SMAD binding | IBA |
| GO:0046332 | SMAD binding | IPI |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IBA |
| GO:0021587 | cerebellum morphogenesis | IMP |
| GO:0021702 | cerebellar Purkinje cell differentiation | IMP |
| GO:0021936 | regulation of cerebellar granule cell precursor proliferation | IMP |
| GO:0030514 | negative regulation of BMP signaling pathway | IBA |
| GO:0030514 | negative regulation of BMP signaling pathway | IGI |
| GO:0045880 | positive regulation of smoothened signaling pathway | IMP |
| GO:0048468 | cell development | IMP |
| GO:0048814 | regulation of dendrite morphogenesis | IMP |
| GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway | IDA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005634 | nucleus | ISO |
| GO:0005634 | nucleus | IDA |
| GO:0005634 | nucleus | IBA |
| GO:0005667 | transcription factor complex | IBA |
| GO:0005737 | cytoplasm | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|