| Tag | Content |
|---|---|
| Uniprot ID | D3ZAH4 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSRNOP00000029409 |
| Ensembl nucleotide ID | ENSRNOG00000018006 |
| Gene name | SKI family transcriptional corepressor 2 |
| Gene symbol | Skor2 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MASSPLPGPN DILLASPSSA FQPDALSQPR PGHANLKPNQ VGQVILYGIP IVSLVIDGQE 60 RLCLAQISNT LLKNFSYNEI HNRRVALGIT CVQCTPVQLE ILRRAGAMPI SSRRCGMITK 120 REAERLCKSF LGENRPPKLP DNFAFDVSHE CAWGCRGSFI PARYNSSRAK CIKCSYCNMY 180 FSPNKFIFHS HRTPDAKYTQ PDAANFNSWR RHLKLTDKSP QDELVFAWED VKAMFNGGSR 240 KRALPQPSAH PACHPLSSVK AAAVAAAAAV AGGGGLLGPH LLGAPPPPPP PPPLAELAGA 300 PHAHHKRPRF DDDDDSLQEA AVVAAASLSA AAASLSVAAA TGGAGPGAGG PGGGCVAGVG 360 VGATAGAGAA AGTKGPRSYP VIPVPSKGSF GGVLQKFPGC GGLFPHPYTF PAAAAAFGLC 420 HKKEDAGTAA EALGGAGAGS AGAAPKAGLS GLFWPAGRKD AFYPPFCMFW PPRTPGGLPV 480 PTYLQPPPQP PSALGCALGD SPALLRQAFL DLAEPGGAGG SAEAAPPPGQ PPPVVANGPG 540 SGPPATGGTG SRDTLFESPP GGSGGDCSAG STPPAEPGVT SGNGATSSGA GSVGTRVPAP 600 HHPHLLEGRK AGGGSYHHSS AFRPVGGKDD KSLAKLHGAS AGAPHSAPAH HHHHHHHPHH 660 HHHHPPQPPS PLLLLQPQPD EPGSERHHPA PPPPPPPPPL APQPHHRGLL SPEGTSCSYP 720 SEDSSEDEED EEEEQEVDVE GHKPLEGEEE EDGRDPEDEE EEEEETRVLL GDSLVGGGRF 780 LQGRGLSEKG SGRDRTTPAV GAFPLALNSS RLLQEDGKLG DPGGSDLPAP PPPSLAPQKA 840 SGGGGSRPGS PVHHPSLEEE PSYKDNQKPK ENNQVILSAK DDNFSDKNKE HSFFITDSDS 900 SGDFWRERSG EHTQETNSPH SLKKDVENMG KEELQKVLFE QIDLRRRLEQ EFQVLKGNSS 960 FPVFNNFQDQ VKRELAYREE MVQQLQIIPY AASLIRKEKL GAHLSKS 1007 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SKOR2 | A0A452E942 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | SKOR2 | 652991 | Q2VWA4 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Skor2 | 664805 | A7M7C7 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | SKOR2 | A0A2I3S940 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | Skor2 | D3ZAH4 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005634 | nucleus |
| GO:0005667 | transcription factor complex |
| GO:0003682 | chromatin binding |
| GO:0042826 | histone deacetylase binding |
| GO:0046332 | SMAD binding |
| GO:0003714 | transcription corepressor activity |
| GO:0048468 | cell development |
| GO:0021702 | cerebellar Purkinje cell differentiation |
| GO:0021587 | cerebellum morphogenesis |
| GO:0030514 | negative regulation of BMP signaling pathway |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway |
| GO:0045880 | positive regulation of smoothened signaling pathway |
| GO:0021936 | regulation of cerebellar granule cell precursor proliferation |
| GO:0048814 | regulation of dendrite morphogenesis |