| Tag | Content |
|---|---|
| Uniprot ID | A0A452ESG5 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSCHIP00000014803 |
| Ensembl nucleotide ID | ENSCHIG00000015683 |
| Gene name | E2F_TDP domain-containing protein |
| Gene symbol | E2F1 |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MAVAGAPAGG PCAPALEALL GAGALRLLDS SQIVIISTAQ DASAPPAPAG PAAPAAGPRD 60 PDLLLFATPQ APRPTPSAPR PALGRPPVKR RLNLETDHQY LAESSGPARG RGRHPGKGVK 120 SPGEKSRYET SLNLTTKRFL ELLSRSADGV VDLNWAAEVL KVQKRRIYDI TNVLEGIQLI 180 AKKSKNHIQW LGNHATVGIG GRLEGLTQDL QQLQESEQQL DHLLHICSTQ LRLLSEDIMW 240 SLTPPTLAYV TCQDLRSIAD PAEQMVMVIK APPETQLQAV DSSENFQISL KSKQGPIDVF 300 LCPEESVGGT SPGKTPSQGA ASGEEDRAAD LATAVPPPPS SPPSSPATDP SQSLLSLEQE 360 PLLSRMGGLR APVDEDRLSP LVAADSLLEH VKEDFSGLLP EEFISLSPPH EALDYHFGLE 420 EGEGIRDLFD CDFGDLTPLD F 441 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | E2F1 | A0A452ESG5 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | E2F1 | 1869 | Q01094 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | E2f1 | 13555 | Q9CYB4 | E12.5, E13.5, E14.5 | Mus musculus | Prediction | More>> | |
| 1:1 ortholog | E2f1 | 399489 | O09139 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005813 | centrosome |
| GO:0005737 | cytoplasm |
| GO:0000790 | nuclear chromatin |
| GO:0005654 | nucleoplasm |
| GO:0035189 | Rb-E2F complex |
| GO:0000987 | cis-regulatory region sequence-specific DNA binding |
| GO:0001216 | DNA-binding transcription activator activity |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0046983 | protein dimerization activity |
| GO:0008134 | transcription factor binding |
| GO:0043276 | anoikis |
| GO:0071466 | cellular response to xenobiotic stimulus |
| GO:0000077 | DNA damage checkpoint |
| GO:0030900 | forebrain development |
| GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator |
| GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage |
| GO:1990086 | lens fiber cell apoptotic process |
| GO:0048255 | mRNA stabilization |
| GO:0043392 | negative regulation of DNA binding |
| GO:0045599 | negative regulation of fat cell differentiation |
| GO:0070345 | negative regulation of fat cell proliferation |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0071930 | negative regulation of transcription involved in G1/S transition of mitotic cell cycle |
| GO:0043065 | positive regulation of apoptotic process |
| GO:0048146 | positive regulation of fibroblast proliferation |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:2000045 | regulation of G1/S transition of mitotic cell cycle |
| GO:0006351 | transcription, DNA-templated |