| Tag | Content |
|---|---|
| Uniprot ID | O09139 |
| Entrez ID | 399489 |
| Genbank protein ID | BAA09641.1 |
| Genbank nucleotide ID | NM_001100778.1 |
| Ensembl protein ID | ENSRNOP00000022428 |
| Ensembl nucleotide ID | ENSRNOG00000016708 |
| Gene name | Transcription factor E2F1 |
| Gene symbol | E2f1 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters. Positively regulates transcription of RRP1B. |
| Sequence | MAVAPAGGQH APALEALLGA GALRLLDSSQ IVIISTAPDV GAPQVPTGPA APPAGPRDPD 60 VLLFATPQAP RPAPSAPRPA LGRPPVKRRL DLETDHQYLA GSSGPFRGRG RHPGKGVKSP 120 GEKSRYETSL NLTTKRFLEL LSHSADGVVD LNWAAEVLKV QKRRIYDITN VLEGIQLIAK 180 KSKNHIQWLG SRTMVGIGQR LEGLTQDLQQ LQESEQQLDH LMHICTTQLQ LLSEDSDIQR 240 LAYVTCQDLR SIADPAEQMV IVIKAPPETQ LQAVDSAETF QISLKSKQGP IDVFLCPEES 300 AEGISPGRTS YQETSGEDRN ADSGTAGPPP SPPSTSPTLD PSQSLLGLEQ EAVLPRIGNL 360 RAPMEEDRLS PLVAADSLLE HVKEDFSGLL PGEFISLSPP HEAVDYHFGL EEGEGIRDLF 420 DCDFGDLTPL DF 432 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | E2F1 | A0A452ESG5 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | E2F1 | 1869 | Q01094 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | E2f1 | 13555 | Q9CYB4 | E12.5, E13.5, E14.5 | Mus musculus | Prediction | More>> | |
| 1:1 ortholog | E2f1 | 399489 | O09139 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005813 | centrosome |
| GO:0005737 | cytoplasm |
| GO:0000790 | nuclear chromatin |
| GO:0005654 | nucleoplasm |
| GO:0005634 | nucleus |
| GO:0032991 | protein-containing complex |
| GO:0035189 | Rb-E2F complex |
| GO:0090575 | RNA polymerase II transcription factor complex |
| GO:0005667 | transcription factor complex |
| GO:0000987 | cis-regulatory region sequence-specific DNA binding |
| GO:0003677 | DNA binding |
| GO:0001216 | DNA-binding transcription activator activity |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0046983 | protein dimerization activity |
| GO:0019901 | protein kinase binding |
| GO:0043565 | sequence-specific DNA binding |
| GO:0008134 | transcription factor binding |
| GO:0044212 | transcription regulatory region DNA binding |
| GO:0043276 | anoikis |
| GO:0071398 | cellular response to fatty acid |
| GO:0071456 | cellular response to hypoxia |
| GO:1990090 | cellular response to nerve growth factor stimulus |
| GO:0071466 | cellular response to xenobiotic stimulus |
| GO:0000077 | DNA damage checkpoint |
| GO:0030900 | forebrain development |
| GO:0000082 | G1/S transition of mitotic cell cycle |
| GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator |
| GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage |
| GO:1990086 | lens fiber cell apoptotic process |
| GO:0048255 | mRNA stabilization |
| GO:0043392 | negative regulation of DNA binding |
| GO:0045599 | negative regulation of fat cell differentiation |
| GO:0070345 | negative regulation of fat cell proliferation |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0071930 | negative regulation of transcription involved in G1/S transition of mitotic cell cycle |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0043065 | positive regulation of apoptotic process |
| GO:0048146 | positive regulation of fibroblast proliferation |
| GO:0010628 | positive regulation of gene expression |
| GO:0060252 | positive regulation of glial cell proliferation |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| GO:0051726 | regulation of cell cycle |
| GO:2000045 | regulation of G1/S transition of mitotic cell cycle |
| GO:0006355 | regulation of transcription, DNA-templated |
| GO:0007283 | spermatogenesis |
| GO:0006351 | transcription, DNA-templated |