| Tag | Content |
|---|---|
| Uniprot ID | A0A452G0B1 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSCHIP00000030047 |
| Ensembl nucleotide ID | ENSCHIG00000024950 |
| Gene name | Fork-head domain-containing protein |
| Gene symbol | FOXC2 |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MQARYSVSDP NALGVVPYLS EQNYYRAAGS YGGMTSPMGV YSGHPEQYGA GMGRSYAPYH 60 HHQPAAPKDL VKPPYSYIAL ITMAIQNAPE KKITLNGIYQ FIMDRFPFYR ENKQGWQNSI 120 RHNLSLNECF VKVPRDDKKP GKGSYWTLDP DSYNMFENGS FLRRRRRFKK KDVPKEKEER 180 AHLKEPPPAA SKGAPAGPPL ADTPKEAEKK VVIKSEAASP ALPVITKVET LSPESALQGS 240 PRSAASTPAG SPDGSLPEHH TGAPNGLPGF SVENIMTLRT SPPGGELSPA AGRAGLVVPP 300 LALPYAAAPP AAYGQPCAQG LEAAGAGGYQ CSMRAMSLYT GAERPAHMCV PPALDEALSD 360 HPSGPTSPLS ALNLAHHGHH HPQAPPPPPA PQPQPAPQPG AAAAQAASWY LNHSGDLNHL 420 SGHSFAAQQQ TFPNVREMFN SHRLGIENST LGEPQVSSNA SCQLPYRSTP SLYRHAAPYS 480 YDCTKY 486 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | FOXC2 | 102153219 | E2QSH3 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | FOXC2 | A0A452G0B1 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | FOXC2 | 2303 | Q99958 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Foxc2 | 14234 | Q61850 | CPO | E11.5, E12.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | FOXC2 | 468058 | H2RA05 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | FOXC2 | A0A287AFQ6 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Foxc2 | 171356 | Q63246 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0016604 | nuclear body |
| GO:0031490 | chromatin DNA binding |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0042802 | identical protein binding |
| GO:1990841 | promoter-specific chromatin binding |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0048844 | artery morphogenesis |
| GO:0001974 | blood vessel remodeling |
| GO:0001569 | branching involved in blood vessel morphogenesis |
| GO:0043010 | camera-type eye development |
| GO:0060038 | cardiac muscle cell proliferation |
| GO:0030199 | collagen fibril organization |
| GO:0035050 | embryonic heart tube development |
| GO:0048703 | embryonic viscerocranium morphogenesis |
| GO:0072011 | glomerular endothelium development |
| GO:0072144 | glomerular mesangial cell development |
| GO:0072112 | glomerular visceral epithelial cell differentiation |
| GO:0008286 | insulin receptor signaling pathway |
| GO:0001946 | lymphangiogenesis |
| GO:0001656 | metanephros development |
| GO:1902257 | negative regulation of apoptotic process involved in outflow tract morphogenesis |
| GO:0120163 | negative regulation of cold-induced thermogenesis |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0014032 | neural crest cell development |
| GO:0007219 | Notch signaling pathway |
| GO:0001503 | ossification |
| GO:0048343 | paraxial mesodermal cell fate commitment |
| GO:0033630 | positive regulation of cell adhesion mediated by integrin |
| GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis |
| GO:0035470 | positive regulation of vascular wound healing |
| GO:0097746 | regulation of blood vessel diameter |
| GO:0046620 | regulation of organ growth |
| GO:0001756 | somitogenesis |
| GO:0001657 | ureteric bud development |
| GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
| GO:0055010 | ventricular cardiac muscle tissue morphogenesis |
| Pfam ID | Pfam Term |
|---|---|
| PF00250 | Forkhead |