| Tag | Content |
|---|---|
| Uniprot ID | H2RA05; A0A2J8LF18; K7CLF5; |
| Entrez ID | 468058 |
| Genbank protein ID | JAA27139.1 |
| Genbank nucleotide ID | XM_016930320.1 |
| Ensembl protein ID | ENSPTRP00000053374 |
| Ensembl nucleotide ID | ENSPTRG00000031133 |
| Gene name | Forkhead box C2 |
| Gene symbol | FOXC2 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MQARYSVSDP NALGVVPYLS EQNYYRAAGS YGGMASPMGV YSGHPEQYSA GMGRSYAPYH 60 HHQPAAPKDL VKPPYSYIAL ITMAIQNAPE KKITLNGIYQ FIMDRFPFYR ENKQGWQNSI 120 RHNLSLNECF VKVPRDDKKP GKGSYWTLDP DSYNMFENGS FLRRRRRFKK KDVSKEKEER 180 AHLKEPPPAA SKGAPATPHL ADAPKEAEKK VVIKSEAASP ALPVITKVET LSPESALQGS 240 PRSAASTPAG SPDGSLPEHH AAAPNGLPGF SVENIMTLRT SPPGGELSPG AGRSGLVVPP 300 LALPYAAAPP AAYGQPCAQG LEAGAAGGYQ CSMRAMSLYT GAERPAHMCV PPALDEALSD 360 HPSGPTSPLS ALNLAAGQEG ALAATGHHHQ HHGHHHPQAP PPPPAPQPQP TPQPGAAAAQ 420 AASWYLNHSG DLNHLPGHTF AAQQQTFPNV REMFNSHRLG IENSTLGESQ VSGNASCQLP 480 YRSTPSLYRH AAPYSYDCTK Y 501 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | FOXC2 | 102153219 | E2QSH3 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | FOXC2 | A0A452G0B1 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | FOXC2 | 2303 | Q99958 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Foxc2 | 14234 | Q61850 | CPO | E11.5, E12.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | FOXC2 | 468058 | H2RA05 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | FOXC2 | A0A287AFQ6 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Foxc2 | 171356 | Q63246 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0016604 | nuclear body |
| GO:0005634 | nucleus |
| GO:0031490 | chromatin DNA binding |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0042802 | identical protein binding |
| GO:1990841 | promoter-specific chromatin binding |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0009653 | anatomical structure morphogenesis |
| GO:0048844 | artery morphogenesis |
| GO:0001974 | blood vessel remodeling |
| GO:0001569 | branching involved in blood vessel morphogenesis |
| GO:0043010 | camera-type eye development |
| GO:0060038 | cardiac muscle cell proliferation |
| GO:0030154 | cell differentiation |
| GO:0030199 | collagen fibril organization |
| GO:0035050 | embryonic heart tube development |
| GO:0048703 | embryonic viscerocranium morphogenesis |
| GO:0072011 | glomerular endothelium development |
| GO:0072144 | glomerular mesangial cell development |
| GO:0072112 | glomerular visceral epithelial cell differentiation |
| GO:0008286 | insulin receptor signaling pathway |
| GO:0001946 | lymphangiogenesis |
| GO:0001656 | metanephros development |
| GO:1902257 | negative regulation of apoptotic process involved in outflow tract morphogenesis |
| GO:0120163 | negative regulation of cold-induced thermogenesis |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0014032 | neural crest cell development |
| GO:0007219 | Notch signaling pathway |
| GO:0001503 | ossification |
| GO:0048343 | paraxial mesodermal cell fate commitment |
| GO:0033630 | positive regulation of cell adhesion mediated by integrin |
| GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis |
| GO:0035470 | positive regulation of vascular wound healing |
| GO:0097746 | regulation of blood vessel diameter |
| GO:0046620 | regulation of organ growth |
| GO:0006357 | regulation of transcription by RNA polymerase II |
| GO:0001756 | somitogenesis |
| GO:0001657 | ureteric bud development |
| GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
| GO:0055010 | ventricular cardiac muscle tissue morphogenesis |
| Pfam ID | Pfam Term |
|---|---|
| PF00250 | Forkhead |