Gene: Foxc2

Basic information

Tag Content
Uniprot ID Q63246; M0R736;
Entrez ID 171356
Genbank protein ID AAA41320.1; EDL92716.1;
Genbank nucleotide ID NM_001101680.1
Ensembl protein ID ENSRNOP00000065254
Ensembl nucleotide ID ENSRNOG00000047446
Gene name Forkhead box protein C2
Gene symbol Foxc2
Organism Rattus norvegicus
NCBI taxa ID 10116
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Transcriptional activator. Might be involved in the formation of special mesenchymal tissues (By similarity).
Sequence
MQARYSVSDP NALGVVPYLS EQNYYRAAGS YGGMASPMGV YSGHPEQYGA GMGRSYAPYH 60
HQPAAPKDLV KPPYSYIALI TMAIQNAPEK KITLNGIYQF IMDRFPFYRE NKQGWQNSIR 120
HNLSLNECFV KVPRDDKKPG KGSYWTLDPD SYNMFENGSF LRRRRRFKKK DVPKDKEERA 180
HLKEPPPASA KGAPTGTPVA DGPKEAEKKV VVKSEAASPA LPVITKVETL SPEGALQASP 240
RSSASTPAGS PDGSLPEHHA AAPNGLPGFS VETIMTLRTS PPGGDLSPAA ARAGLVVPPL 300
ALPYAAAPPA AYAQPCAQGL EAAGSAGYQC SMRAMSLYTG AERPAHVCVP PALDEALSDH 360
PSGPGSPLGA LNLAAGQEGA LGASGHHHQH HSHLHPQAPP PAPQPPPAPQ PATQATSWYL 420
NHGGDLSHLP GHTFATQQQT FPNVREMFNS HRLGLDNSTL GESQVSNASC QLPYRATPSL 480
YRHAAPYSYD CTKY 494

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologFOXC2102153219E2QSH3Canis lupus familiarisPredictionMore>>
1:1 orthologFOXC2A0A452G0B1Capra hircusPredictionMore>>
1:1 orthologFOXC22303Q99958Homo sapiensPredictionMore>>
1:1 orthologFoxc214234Q61850CPOE11.5, E12.5Mus musculusPublicationMore>>
1:1 orthologFOXC2468058H2RA05Pan troglodytesPredictionMore>>
1:1 orthologFOXC2A0A287AFQ6Sus scrofaPredictionMore>>
1:1 orthologFoxc2171356Q63246Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0016604 nuclear body
GO:0005634 nucleus
GO:0031490 chromatin DNA binding
GO:0003677 DNA binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003700 DNA-binding transcription factor activity
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0042802 identical protein binding
GO:1990841 promoter-specific chromatin binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0009653 anatomical structure morphogenesis
GO:0048844 artery morphogenesis
GO:0001568 blood vessel development
GO:0001974 blood vessel remodeling
GO:0001569 branching involved in blood vessel morphogenesis
GO:0043010 camera-type eye development
GO:0060038 cardiac muscle cell proliferation
GO:0030154 cell differentiation
GO:0008283 cell population proliferation
GO:0030199 collagen fibril organization
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0035050 embryonic heart tube development
GO:0048704 embryonic skeletal system morphogenesis
GO:0048703 embryonic viscerocranium morphogenesis
GO:0072011 glomerular endothelium development
GO:0072144 glomerular mesangial cell development
GO:0072112 glomerular visceral epithelial cell differentiation
GO:0007507 heart development
GO:0003007 heart morphogenesis
GO:0008286 insulin receptor signaling pathway
GO:0001822 kidney development
GO:0001945 lymph vessel development
GO:0001946 lymphangiogenesis
GO:0001656 metanephros development
GO:1902257 negative regulation of apoptotic process involved in outflow tract morphogenesis
GO:0120163 negative regulation of cold-induced thermogenesis
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0014032 neural crest cell development
GO:0007219 Notch signaling pathway
GO:0001503 ossification
GO:0048341 paraxial mesoderm formation
GO:0048343 paraxial mesodermal cell fate commitment
GO:0033630 positive regulation of cell adhesion mediated by integrin
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis
GO:0010595 positive regulation of endothelial cell migration
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045893 positive regulation of transcription, DNA-templated
GO:0035470 positive regulation of vascular wound healing
GO:0097746 regulation of blood vessel diameter
GO:0046620 regulation of organ growth
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006355 regulation of transcription, DNA-templated
GO:0009725 response to hormone
GO:0001501 skeletal system development
GO:0001756 somitogenesis
GO:0001657 ureteric bud development
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0055010 ventricular cardiac muscle tissue morphogenesis

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0010 Activator
KW-0217 Developmental protein
KW-0238 DNA-binding
KW-1017 Isopeptide bond
KW-0488 Methylation
KW-0539 Nucleus
KW-0597 Phosphoprotein
KW-1185 Reference proteome
KW-0804 Transcription
KW-0805 Transcription regulation
KW-0832 Ubl conjugation

Interpro

InterPro ID InterPro Term
IPR001766 Fork_head_dom
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

PROSITE

PROSITE ID PROSITE Term
PS00657 FORK_HEAD_1
PS00658 FORK_HEAD_2
PS50039 FORK_HEAD_3

Pfam

Pfam ID Pfam Term
PF00250 Forkhead