Gene:

Basic information

Tag Content
Uniprot ID A0A4X1WBK2
Entrez ID
Genbank protein ID
Genbank nucleotide ID
Ensembl protein ID ENSSSCP00070051866
Ensembl nucleotide ID ENSSSCG00070030245
Gene name IF rod domain-containing protein
Gene symbol
Organism Sus scrofa
NCBI taxa ID 9823
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MSFSTQSSFS SYRSVQSPGH RVRPVSSAAS VYAGAGGSGS RISVSRSSSV RGGSGWGAGM 60
AGGLVGVGGI QGEKETMQDL NDRLASYLER VRSLEADNRR LEIKIREHLE KKGPQVRDWS 120
HYLKTIEELR AQIFASSVDN ARIVLQIDNA RLAADDFRVK YETELAMRQS VESDIHGLRK 180
VIDDTNVTRL QLETEIEALK EELLFMKKNH EEEVKGLQNQ IANSGLTVEL DAPKPQDLSK 240
IMADIRAQYD ELAQKNREEL DKYWSQQIEE STSVVTSQSA EIGAAEMTLT ELRRTVQSLE 300
IDLDSMRNLK ATLENSLREV EARYALQMEQ LNGVLLHLES ELAQTRAEGQ RQTQEYEALL 360
NIKVKLEAEI NTYRRLLEDG EDFNLGDALD SSNSRQTIQK TTTLRLVDGK VVSETSDTKV 420
LRH 423

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologKRT18506480F6S1Q0Bos taurusPredictionMore>>
1:1 orthologKRT183875P05783Homo sapiensPublicationMore>>
1:1 orthologKrt1816668P05784Mus musculusPredictionMore>>
1:1 orthologKRT18451923H2Q609Pan troglodytesPredictionMore>>
1:1 orthologA0A4X1WBK2Sus scrofaPredictionMore>>
1:1 orthologKrt18294853Q5BJY9Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0071944 cell periphery
GO:0034451 centriolar satellite
GO:0005829 cytosol
GO:0045095 keratin filament
GO:0097110 scaffold protein binding
GO:0005198 structural molecule activity
GO:0097191 extrinsic apoptotic signaling pathway
GO:0043000 Golgi to plasma membrane CFTR protein transport
GO:0097284 hepatocyte apoptotic process
GO:0045104 intermediate filament cytoskeleton organization
GO:0043066 negative regulation of apoptotic process
GO:0033209 tumor necrosis factor-mediated signaling pathway

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0175 Coiled coil
KW-0403 Intermediate filament

Interpro

InterPro ID InterPro Term
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR042180 IF_rod_dom_coil1B
IPR027695 Keratin-18
IPR002957 Keratin_I

PROSITE

PROSITE ID PROSITE Term
PS00226 IF_ROD_1
PS51842 IF_ROD_2

Pfam

Pfam ID Pfam Term
PF00038 Filament