| Tag | Content |
|---|---|
| Uniprot ID | Q5BJY9; Q63278; |
| Entrez ID | 294853 |
| Genbank protein ID | CAA57204.1; AAH91275.1; |
| Genbank nucleotide ID | NM_053976.1 |
| Ensembl protein ID | ENSRNOP00000067234 |
| Ensembl nucleotide ID | ENSRNOG00000047393 |
| Gene name | Keratin, type I cytoskeletal 18 |
| Gene symbol | Krt18 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection (By similarity). Involved in the uptake of thrombin-antithrombin complexes by hepatic cells. |
| Sequence | MSFTTRSTTF STNYRSLGSV RTPSQRVRPA SSAASVYAGA GGSGSRISVS RSVWGGSVGS 60 AGLAGMGGVQ TEKETMQDLN DRLASYLDKV KNLETENRRL ESKIREYLEK RGPQGVRDWG 120 HYFKTIEDLR AQIFANSVDN ARIVLQIDNA RLAADDFRVK YETELAMRQS VESDIHGLRK 180 VVDDTNITRL QLETEIEALK EELLFMKKNH EEEVQGLEAQ IASSGLTVEV DAPKSQDLSK 240 IMADIRAQYE QLAQKNREEL DKYWSQQIEE STTVVTTKSA EIRDAETTLL ELRRTLQTLE 300 IDLDSMKNQN INLENNLGEV EARYRVQMEQ LNGVLLHLES ELAQTRAEGQ RQTQEYEALL 360 NIKVKLEAEI ATYRRLLEDG DDFSLNDALD SSNSMQTVQR TTTRKVVDGK VVSETNDTRV 420 LRH 423 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | KRT18 | 506480 | F6S1Q0 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | KRT18 | 3875 | P05783 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Krt18 | 16668 | P05784 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | KRT18 | 451923 | H2Q609 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | A0A4X1WBK2 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | Krt18 | 294853 | Q5BJY9 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0071944 | cell periphery |
| GO:0034451 | centriolar satellite |
| GO:0005737 | cytoplasm |
| GO:0005829 | cytosol |
| GO:0005882 | intermediate filament |
| GO:0045095 | keratin filament |
| GO:0005815 | microtubule organizing center |
| GO:0016363 | nuclear matrix |
| GO:0005730 | nucleolus |
| GO:0097110 | scaffold protein binding |
| GO:0005198 | structural molecule activity |
| GO:0097191 | extrinsic apoptotic signaling pathway |
| GO:0043000 | Golgi to plasma membrane CFTR protein transport |
| GO:0097284 | hepatocyte apoptotic process |
| GO:0045104 | intermediate filament cytoskeleton organization |
| GO:0043066 | negative regulation of apoptotic process |
| GO:0033209 | tumor necrosis factor-mediated signaling pathway |
| Keyword ID | Keyword Term |
|---|---|
| KW-0007 | Acetylation |
| KW-0175 | Coiled coil |
| KW-0963 | Cytoplasm |
| KW-0903 | Direct protein sequencing |
| KW-0325 | Glycoprotein |
| KW-0403 | Intermediate filament |
| KW-1017 | Isopeptide bond |
| KW-0416 | Keratin |
| KW-0488 | Methylation |
| KW-0539 | Nucleus |
| KW-0597 | Phosphoprotein |
| KW-1185 | Reference proteome |
| KW-0832 | Ubl conjugation |
| Pfam ID | Pfam Term |
|---|---|
| PF00038 | Filament |