Gene: Kdf1

Basic information

Tag Content
Uniprot ID A2A9F4; Q8C1Q5;
Entrez ID 69073
Genbank protein ID BAC25177.1
Genbank nucleotide ID NM_133707.2; XM_006539151.3; XM_006539150.3; NM_001083916.1;
Ensembl protein ID ENSMUSP00000048768; ENSMUSP00000101521;
Ensembl nucleotide ID ENSMUSG00000037600
Gene name Keratinocyte differentiation factor 1
Gene symbol Kdf1
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage
Data sources Manually collected
Reference 24075906
Functional description Plays a role in the regulation of the epidermis formation during early development. Required both as an inhibitor of basal cell proliferation and a promoter of differentiation of basal progenitor cell progeny.
Sequence
MPRPGQPRPS SGPPRLGPWE RPSELCLETN DERSQPPPGR RTRRPDPKDP GHHGPESITF 60
ISGSAEPANE PPTCCLLWRP WGWDWCRAAF CFRRCRDCLQ RCGACVRGCS PCLSAGDPIE 120
GSAEAAWAKE HNGVPPSPDR APPSRRDGQR LKTSMGSSFS YPDVKLKGIP VYPYRHATSP 180
VPDVDSCCKE PLAEPPPTRH SLPSTFTNSP RGSEEYYSFH ESDLDLPEMG SGSMSSREID 240
VLIFKKLTEL FSVHQIDELA KCTSDTVFLE KTSKISDLIS SITQDYHLDE QDAEGRLVRG 300
IIRISTRKSR SRPQTSEGRS ARSTAPAAAP DSGHETMLGS GLSQDELTVQ ISQETTADAI 360
ARKLRPYGAP GYPASQDSSF QGTDTDSSGA PLLQVYC 397

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologKDF1540019A5PJK4Bos taurusPredictionMore>>
1:1 orthologKDF1612121E2R9Y8Canis lupus familiarisPredictionMore>>
1:1 orthologKDF1102179821A0A452FYZ0Capra hircusPredictionMore>>
1:1 orthologKDF1100057007F7DZ26Equus caballusPredictionMore>>
1:1 orthologKDF1126695Q8NAX2Homo sapiensPredictionMore>>
1:1 orthologKdf169073A2A9F4CPOMus musculusPublicationMore>>
1:1 orthologKDF1737621H2PYE8Pan troglodytesPredictionMore>>
1:1 orthologKDF1100511202F1STQ5Sus scrofaPredictionMore>>
1:1 orthologKDF1100357150G1SQZ0Oryctolagus cuniculusPredictionMore>>
1:1 orthologkdf1a797923E7F2A2Danio rerioPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0003674 molecular_functionND

GO:Biological Process

GO ID GO Term Evidence
GO:0003334 keratinocyte developmentIGI
GO:0003334 keratinocyte developmentIMP
GO:0010482 regulation of epidermal cell divisionIBA
GO:0010482 regulation of epidermal cell divisionIMP
GO:0010839 negative regulation of keratinocyte proliferationIGI
GO:0010839 negative regulation of keratinocyte proliferationIMP
GO:0016331 morphogenesis of embryonic epitheliumIMP
GO:0045606 positive regulation of epidermal cell differentiationIMP
GO:0048589 developmental growthIMP
GO:0060887 limb epidermis developmentIMP
GO:0061436 establishment of skin barrierIMP
GO:2000647 negative regulation of stem cell proliferationIMP

GO:Cellular Component

GO ID GO Term Evidence
GO:0005654 nucleoplasmISO
GO:0005737 cytoplasmIDA
GO:0005938 cell cortexIDA
GO:0030054 cell junctionISO
GO:0030054 cell junctionIBA
GO:0030054 cell junctionIDA
GO:0031252 cell leading edgeIDA
GO:0072686 mitotic spindleISO

Reactome Pathway

Reactome ID Reactome Term Evidence

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0965 Cell junction
KW-0963 Cytoplasm
KW-0217 Developmental protein
KW-0221 Differentiation
KW-0597 Phosphoprotein
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR028003 KDF1

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF15551 DUF4656