| Tag | Content |
|---|---|
| Uniprot ID | A5D7J4 |
| Entrez ID | 506721 |
| Genbank protein ID | ALT07797.1; AAI40580.1; |
| Genbank nucleotide ID | NM_001097991.1 |
| Ensembl protein ID | ENSBTAP00000011939 |
| Ensembl nucleotide ID | ENSBTAG00000009059 |
| Gene name | Homeobox protein |
| Gene symbol | PITX2 |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MNCMKGPLHL EHRAAGTKLL AASSSSSCHH PQPLAMASVL APGQARSLDS SKHRLEVHTI 60 SDTPSPEAAE KDKSQQGKNE DVGAEDPSKK KRQRRQRTHF TSQQLQELEA TFQRNRYPDM 120 STREEIAVWT NLTEARVRVW FKNRRAKWRK RERNQQAELC KNGFGPQFNG LMQPYDDMYP 180 GYSYNNWAAK GLTSASLSTK SFPFFNSMNV NPLSSQSMFS PPNSISSMSM SSSMVPSAVT 240 GVPGSSLNSL NNLNNLSSPS LNSAVPTPAC PYAPPTPPYV YRDTCNSSLA SLRLKAKQHS 300 SFGYASVQNP ASNLSACQYA VDRPV 325 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PITX2 | 506721 | A5D7J4 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | PITX2 | 487902 | E2R5R2 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | PITX2 | 102180740 | A0A452E417 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | PITX2 | 5308 | Q99697 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Pitx2 | 18741 | P97474 | CPO | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | PITX2 | 461438 | K7DFT6 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | PITX2 | A0A287AUF8 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Pitx2 | 54284 | Q9R0W1 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | pitx2 | 30164 | Q9W5Z2 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005654 | nucleoplasm |
| GO:0005634 | nucleus |
| GO:0005667 | transcription factor complex |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0001102 | RNA polymerase II activating transcription factor binding |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0001085 | RNA polymerase II transcription factor binding |
| GO:0043565 | sequence-specific DNA binding |
| GO:0009653 | anatomical structure morphogenesis |
| GO:0035993 | deltoid tuberosity development |
| GO:0061072 | iris morphogenesis |
| GO:0042476 | odontogenesis |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |