| Tag | Content |
|---|---|
| Uniprot ID | Q9R0W1 |
| Entrez ID | 54284 |
| Genbank protein ID | CAB52283.1; CAB52284.1; AAC70909.1; |
| Genbank nucleotide ID | XM_017591054.1; NM_001042505.1; NM_019334.2; |
| Ensembl protein ID | ENSRNOP00000043402; ENSRNOP00000046259; |
| Ensembl nucleotide ID | ENSRNOG00000010681 |
| Gene name | Pituitary homeobox 2 |
| Gene symbol | Pitx2 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach (By similarity). |
| Sequence | MNCMKGPLPL EHRAAGTKLS AASSPFCHHT QALAMASVLA PGQPRSLDAS KHRLEVHTIS 60 DTSSPEVAEK DKGQQGKNED VGAEDPSKKK RQRRQRTHFT SQQLQELEAT FQRNRYPDMS 120 TREEIAVWTN LTEARVRVWF KNRRAKWRKR ERNQQAELCK NGFGPQFNGL MQPYDDMYPG 180 YSYNNWAAKG LTSASLSTKS FPFFNSMNVN PLSSQSMFSP PNSISSMSMS SSMVPSAVTG 240 VPGSSLNSLN NLNNLSSPSL NSAVPTPACP YAPPTPPYVY RDTCNSSLAS LRLKAKQHSS 300 FGYASVQNPA SNLSACQYAV DRPV 324 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PITX2 | 506721 | A5D7J4 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | PITX2 | 487902 | E2R5R2 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | PITX2 | 102180740 | A0A452E417 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | PITX2 | 5308 | Q99697 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Pitx2 | 18741 | P97474 | CPO | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | PITX2 | 461438 | K7DFT6 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | PITX2 | A0A287AUF8 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Pitx2 | 54284 | Q9R0W1 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | pitx2 | 30164 | Q9W5Z2 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005634 | nucleus |
| GO:0005667 | transcription factor complex |
| GO:0003682 | chromatin binding |
| GO:0031490 | chromatin DNA binding |
| GO:0003677 | DNA binding |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| GO:0042802 | identical protein binding |
| GO:0051219 | phosphoprotein binding |
| GO:0042803 | protein homodimerization activity |
| GO:0001102 | RNA polymerase II activating transcription factor binding |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0001085 | RNA polymerase II transcription factor binding |
| GO:0043565 | sequence-specific DNA binding |
| GO:0008134 | transcription factor binding |
| GO:0000976 | transcription regulatory region sequence-specific DNA binding |
| GO:0009653 | anatomical structure morphogenesis |
| GO:0009887 | animal organ morphogenesis |
| GO:0055009 | atrial cardiac muscle tissue morphogenesis |
| GO:0003171 | atrioventricular valve development |
| GO:0007420 | brain development |
| GO:0001569 | branching involved in blood vessel morphogenesis |
| GO:0043010 | camera-type eye development |
| GO:0055007 | cardiac muscle cell differentiation |
| GO:0048738 | cardiac muscle tissue development |
| GO:0003253 | cardiac neural crest cell migration involved in outflow tract morphogenesis |
| GO:0061325 | cell proliferation involved in outflow tract morphogenesis |
| GO:0035993 | deltoid tuberosity development |
| GO:0007368 | determination of left/right symmetry |
| GO:0055123 | digestive system development |
| GO:0031076 | embryonic camera-type eye development |
| GO:0048557 | embryonic digestive tract morphogenesis |
| GO:0035116 | embryonic hindlimb morphogenesis |
| GO:0061031 | endodermal digestive tract morphogenesis |
| GO:0002074 | extraocular skeletal muscle development |
| GO:0008585 | female gonad development |
| GO:0007507 | heart development |
| GO:0021855 | hypothalamus cell migration |
| GO:0001701 | in utero embryonic development |
| GO:0061072 | iris morphogenesis |
| GO:0060460 | left lung morphogenesis |
| GO:0070986 | left/right axis specification |
| GO:0030324 | lung development |
| GO:0008584 | male gonad development |
| GO:0007520 | myoblast fusion |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0030182 | neuron differentiation |
| GO:0001764 | neuron migration |
| GO:0042476 | odontogenesis |
| GO:0042475 | odontogenesis of dentin-containing tooth |
| GO:0021983 | pituitary gland development |
| GO:0043388 | positive regulation of DNA binding |
| GO:2000288 | positive regulation of myoblast proliferation |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| GO:0003350 | pulmonary myocardium development |
| GO:0060577 | pulmonary vein morphogenesis |
| GO:0030334 | regulation of cell migration |
| GO:0042127 | regulation of cell population proliferation |
| GO:0006357 | regulation of transcription by RNA polymerase II |
| GO:0006355 | regulation of transcription, DNA-templated |
| GO:0009725 | response to hormone |
| GO:0033189 | response to vitamin A |
| GO:0007519 | skeletal muscle tissue development |
| GO:0048536 | spleen development |
| GO:0021763 | subthalamic nucleus development |
| GO:0060578 | superior vena cava morphogenesis |
| GO:0035886 | vascular smooth muscle cell differentiation |
| GO:0001570 | vasculogenesis |
| GO:0055015 | ventricular cardiac muscle cell development |
| GO:0060412 | ventricular septum morphogenesis |
| GO:0016055 | Wnt signaling pathway |