| Tag | Content |
|---|---|
| Uniprot ID | B0R0T1 |
| Entrez ID | 561317 |
| Genbank protein ID | CAQ14674.1; CAQ14217.1; |
| Genbank nucleotide ID | NM_001128338.1 |
| Ensembl protein ID | ENSDARP00000120404 |
| Ensembl nucleotide ID | ENSDARG00000078593 |
| Gene name | von Willebrand factor A domain-containing protein 8 |
| Gene symbol | vax2 |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Exhibits ATPase activity in vitro. |
| Sequence | MHSRILFKGT AAAVAARRIR HILGPLMSKE GWNCSAHEVK LLNTSSGDTV KIGEISYVLK 60 TPKNPELVPV NHMMEALPQM VTQHLRWIMQ KDLLGQDVFL IGPPGPLRRS IAMQYLELTK 120 REVEYVALSR DTTETDLKQR REIRSGTAFY IDQCAVRAAT EGRILVLEGL EKAERNVLPV 180 LNNLLENREM QLEDGRFLMS AHRYDKLLEE HTKEELDAWK IVRVSEDFRV IALGLPVPRY 240 KGNPLDPPLR SRFQARDIYY LPFKDQLEHL YRIGANVSAE RVSQLLSFAT TLCSQESASL 300 SLPDFPVDNL PSALTVLNLF PMLSVQQLVQ RLYPYEAMLG KEGRTAVEGV LNRFELTDGS 360 TKPSPTAVVN IEPVNGGQAE QAAVTLNITN QKITFQVPSG TRPIRPPNSS PTFINTPTHE 420 RLLAEMMQSH LVKDICLIGA KGCGKSVIAR EFAEMLGYSI EPVMLYQDMT ARDLLQQRYT 480 LPNGDTAWRA SPLVTAAQEG KLVLLDGIHR VNLGTLAVLS RLLHDRELDL YDGTRLLRFD 540 RYQALKEELQ LTDQQLQDRS IFPIHPSFRI IALAEPPVIG STTQQWLNPE ILTMFLFHTI 600 KPLAKAEETA VLQGMIPNVP GEAVEQLQHL THSLRKSNDP TALSLASSLS TRQLLRICRR 660 LSQYPQESVA HAVHKACLSR FLPSLARSSL EKSLANCSIE DHPDPASEQK QLYTCTVKDG 720 LLTIGNVSAP VYSPDEKMKV PDVLFYENVQ HMMVMQDMLK DFLLGEHLLL VGNQGVGKNK 780 IVDRFLHLMN RPREYLQLHR DTTVQTLTLQ PSVRDGIIIY EDSPLVKAVK MGHILVIDEA 840 DKAPTNVTCI LKALVESGEM ILADGRRIVS DALEAAGRPN AIPMHPDFRM IVLANRPGFP 900 FLGNDFFGAL GDIFSCHAVD NPKPQAEFAM LKQYGPDVPD AVLQKLVAAF GELRAMADQG 960 TITYPYSTRE VVNIVKHLQK FPDEGLANVV RNVFDFDSYN KDMREVLISA LHKHGIPIGA 1020 KPTSVHLAKE LPLPDCKMTG YWTISQGGNT RRKLLCPTET HRIDIKGPVF LRVQSYPSKR 1080 HESRSLSFTE EQAHWQIPMN EVNIVCDVTT AKDSIYVATC NPVSLYAMKE KGDSVQCIEL 1140 YDIFPRTISG VWQPFVSVAA LGNPLQDQVV LHEEQGNTVL HLDLVTGAVR RLILSQDKQD 1200 EAPRKTSNWW NSKESQPGYK MCKEFAHKNW LLFYKENGNQ LDVVDVLEGQ VHTIHLPINL 1260 KAVFLVAEDR WLLVESKTDR KFLLTKPMHM GAEETGVCQL HAISEDAVSS GFGNNSGMEA 1320 VSPQEVSSDQ LSNENLSAAL GQKIVSPNRI LCDTNTYANV IVGFPDLMSP NELYSFRRSL 1380 PITESRRPDM FFGSSKRTGP AKRVNCVCLL DANQVVRALP PTQVPLAEVY PKDVTPPMSA 1440 AYLEVTDLNS KRLKYIPVPR SNSMSPYTVW ISKVSDTDVV MAPLGSGGVV TVDMGGYVRL 1500 WETGLDHLQR SLLEWRNMIG SEDGRPVQIT IERDSGLDVS SPKHGKIDAK NAPHVGGNQW 1560 AGGTGGRDTA GLGGKGGPYR LDAGHKVYQI SQAEKDAVPD EVKRAARDMA EQAFKQRLKE 1620 IEMSEYDAST YDRFSGAVRR QVQSLRIILD SLQAKGKERQ WLRNQALGEL DDAKIIDGLT 1680 GEKSIYKRRG ELEPELGSPQ QKPKRLRVLA DVSGSMYRFN GVDGRLERSM EAVCMVMEAL 1740 ESYEHKFKYD ITGHSGDGFD IELVRCDKVP KNNKERLKVL KTMHAHSQFC MSGDYTLEGT 1800 EHAIRELAHE EADEHFVIVL SDANLERYGI SPDRFARVLT SNPQVNAFAI FIGSLGDQAD 1860 RLQKTLPAGR SFVAMDTKEI PQILQQIFTS TMLSSA 1896 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | VWA8 | 485463 | F1PD22 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | VWA8 | A0A452ENV0 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | VWA8 | 23078 | A3KMH1 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Vwa8 | 219189 | Q8CC88 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | VWA8 | 452560 | H2Q7H4 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | VWA8 | I3LJL2 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | VWA8 | G1T8E0 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | vax2 | 561317 | B0R0T1 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005739 | mitochondrion |
| GO:0005524 | ATP binding |
| GO:0016887 | ATPase activity |
| PROSITE ID | PROSITE Term |
|---|---|
| PS50234 | VWFA |
| Pfam ID | Pfam Term |
|---|---|
| PF07728 | AAA_5 |