Gene: Satb2

Basic information

Tag Content
Uniprot ID D3ZJ19
Entrez ID 501145
Genbank protein ID EDL99029.1
Genbank nucleotide ID NM_001109306.1
Ensembl protein ID ENSRNOP00000071049; ENSRNOP00000044829;
Ensembl nucleotide ID ENSRNOG00000010188
Gene name DNA-binding protein SATB
Gene symbol Satb2
Organism Rattus norvegicus
NCBI taxa ID 10116
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MERRSESPCL RDSPDRRSGS PDVKGPPPVK VARLEQNGSP MGARGRPNGA VAKAVGGLMI 60
PVFCVVEQLD GSLEYDNREE HAEFVLVRKD VLFSQLVETA LLALGYSHSS AAQAQGIIKL 120
GRWNPLPLSY VTDAPDATVA DMLQDVYHVV TLKIQLQSCS KLEDLPAEQW NHATVRNALK 180
ELLKEMNQST LAKECPLSQS MISSIVNSTY YANVSATKCQ EFGRWYKKYK KIKVERVERE 240
NLSDYCVLGQ RPMHLPNMNQ LASLGKTNEQ SPHSQIHHST PIRNQVPALQ PIMSPGLLSP 300
QLSPQLVRQQ IAMAHLINQQ IAVSRLLAHQ HPQAINQQFL NHPPIPRAVK PEPTNSSVEV 360
SPDIYQQVRD ELKRASVSQA VFARVAFNRT QGLLSEILRK EEDPRTASQS LLVNLRAMQN 420
FLNLPEVERD RIYQDERERS MNPNVSMVSS ASSSPSSSRT PQAKTSTPTT DLPIKVDGAN 480
VNITAAIYDE IQQEMKRAKV SQALFAKVAA NKSQGWLCEL LRWKENPSPE NRTLWENLCT 540
IRRFLNLPQH ERDVIYEEES RHHHSERMQH VVQLPPEPVQ VLHRQQSQPT KESSPPREEA 600
PPPPPPTEDS CAKKPRSRTK ISLEALGILQ SFIHDVGLYP DQEAIHTLSA QLDLPKHTII 660
KFFQNQRYHV KHHGKLKEHL GSAVDVAEYK DEELLTESEE NDSEEGSDEM YKVEAEEESA 720
EKNKVAPAET DQR 733

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologSATB2102171018A0A452FN88Capra hircusPredictionMore>>
1:1 orthologSATB223314Q9UPW6Homo sapiensPublicationMore>>
1:1 orthologSatb2212712Q8VI24CPOE12.5, E14.25, E13.5, E14.5, E16.5Mus musculusPublicationMore>>
1:1 orthologSATB2459856A0A2I3SX19Pan troglodytesPredictionMore>>
1:1 orthologSATB2I3LRU7Sus scrofaPredictionMore>>
1:1 orthologSATB2100351405G1SXR2Oryctolagus cuniculusPredictionMore>>
1:1 orthologSatb2501145D3ZJ19Rattus norvegicusPredictionMore>>
1:1 orthologsatb2563435A8WIP9Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0000118 histone deacetylase complex
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0003682 chromatin binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0043565 sequence-specific DNA binding
GO:0051216 cartilage development
GO:0071310 cellular response to organic substance
GO:0006338 chromatin remodeling
GO:0021902 commitment of neuronal cell to specific neuron type in forebrain
GO:0009880 embryonic pattern specification
GO:0048704 embryonic skeletal system morphogenesis
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001764 neuron migration
GO:0002076 osteoblast development
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0010468 regulation of gene expression
GO:0006357 regulation of transcription by RNA polymerase II
GO:0060021 roof of mouth development

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0238 DNA-binding
KW-0371 Homeobox
KW-0539 Nucleus
KW-1185 Reference proteome
KW-0804 Transcription
KW-0805 Transcription regulation

Interpro

InterPro ID InterPro Term
IPR003350 CUT_dom
IPR032355 CUTL
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
IPR039673 SATB1/SATB2
IPR038216 SATB_CUTL_sf
IPR038224 SATB_ULD_sf
IPR032392 ULD

PROSITE

PROSITE ID PROSITE Term
PS51042 CUT
PS50071 HOMEOBOX_2

Pfam

Pfam ID Pfam Term
PF02376 CUT
PF16557 CUTL
PF00046 Homeodomain
PF16534 ULD