Gene: SIX1

Basic information

Tag Content
Uniprot ID E5DCJ4
Entrez ID 100156847
Genbank protein ID ADQ54113.1; ADQ54114.1;
Genbank nucleotide ID NM_001199718.1
Ensembl protein ID ENSSSCP00000005467
Ensembl nucleotide ID ENSSSCG00000005087
Gene name Six homeobox 1
Gene symbol SIX1
Organism Sus scrofa
NCBI taxa ID 9823
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MSMLPSFGFT QEQVACVCEV LQQGGNLERL GRFLWSLPAC DHLHKNESVL KAKAVVAFHR 60
GNFRELYKIL ESHQFSPHNH PKLQQLWLKA HYVEAEKLRG RPLGAVGKYR VRRKFPLPRT 120
IWDGEETSYC FKEKSRGVLR EWYAHNPYPS PREKRELAEA TGLTTTQVSN WFKNRRQRDR 180
AAEAKERENT ENNNSSSNKQ NQLSPLEGGK PLMSSSEEEF SPPQSPDQNS VLLLQGNMGH 240
ARSSNYSLPG LTASQPTHGL QAHQHQLQDS LLGPLTSSLV DLGS 284

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologSIX1Q08DI4Bos taurusPredictionMore>>
1:1 orthologSIX1490719J9P3S7Canis lupus familiarisPredictionMore>>
1:1 orthologSIX1106502564A0A452G009Capra hircusPredictionMore>>
1:1 orthologSIX16495Q15475Homo sapiensPredictionMore>>
1:1 orthologSix120471Q62231CPOMus musculusPublicationMore>>
1:1 orthologSIX1452952H2Q8E8Pan troglodytesPredictionMore>>
1:1 orthologSIX1100156847E5DCJ4Sus scrofaPredictionMore>>
1:1 orthologSIX1100349440G1T717Oryctolagus cuniculusPredictionMore>>
1:1 orthologSix1114634G3V970Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005730 nucleolus
GO:0005654 nucleoplasm
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0003682 chromatin binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003700 DNA-binding transcription factor activity
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0043565 sequence-specific DNA binding
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0048856 anatomical structure development
GO:0035909 aorta morphogenesis
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0090103 cochlea morphogenesis
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048704 embryonic skeletal system morphogenesis
GO:0030855 epithelial cell differentiation
GO:0021610 facial nerve morphogenesis
GO:0061197 fungiform papilla morphogenesis
GO:0048699 generation of neurons
GO:0048839 inner ear development
GO:0042472 inner ear morphogenesis
GO:0001822 kidney development
GO:0072172 mesonephric tubule formation
GO:0072075 metanephric mesenchyme development
GO:0042474 middle ear morphogenesis
GO:0051451 myoblast migration
GO:0061055 myotome development
GO:0043524 negative regulation of neuron apoptotic process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048665 neuron fate specification
GO:0030910 olfactory placode formation
GO:0001759 organ induction
GO:0071599 otic vesicle development
GO:0003151 outflow tract morphogenesis
GO:0007389 pattern specification process
GO:0060037 pharyngeal system development
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
GO:0090336 positive regulation of brown fat cell differentiation
GO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development
GO:0072513 positive regulation of secondary heart field cardioblast proliferation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045893 positive regulation of transcription, DNA-templated
GO:0072107 positive regulation of ureteric bud formation
GO:0034504 protein localization to nucleus
GO:0072095 regulation of branch elongation involved in ureteric bud branching
GO:0050678 regulation of epithelial cell proliferation
GO:0045664 regulation of neuron differentiation
GO:0032880 regulation of protein localization
GO:2001014 regulation of skeletal muscle cell differentiation
GO:0014857 regulation of skeletal muscle cell proliferation
GO:0014842 regulation of skeletal muscle satellite cell proliferation
GO:0008582 regulation of synaptic growth at neuromuscular junction
GO:0006355 regulation of transcription, DNA-templated
GO:0007605 sensory perception of sound
GO:0048741 skeletal muscle fiber development
GO:0007519 skeletal muscle tissue development
GO:0048538 thymus development
GO:0030878 thyroid gland development
GO:0061551 trigeminal ganglion development
GO:0072193 ureter smooth muscle cell differentiation
GO:0001657 ureteric bud development

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0238 DNA-binding
KW-0371 Homeobox
KW-0539 Nucleus
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR031278 SIX1
IPR031701 SIX1_SD

PROSITE

PROSITE ID PROSITE Term
PS00027 HOMEOBOX_1
PS50071 HOMEOBOX_2

Pfam

Pfam ID Pfam Term
PF00046 Homeodomain
PF16878 SIX1_SD