| Tag | Content |
|---|---|
| Uniprot ID | G3V970 |
| Entrez ID | 114634 |
| Genbank protein ID | EDM03607.1 |
| Genbank nucleotide ID | NM_053759.1 |
| Ensembl protein ID | ENSRNOP00000037345 |
| Ensembl nucleotide ID | ENSRNOG00000022777 |
| Gene name | SIX homeobox 1 |
| Gene symbol | Six1 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MSMLPSFGFT QEQVACVCEV LQQGGNLERL GRFLWSLPAC DHLHKNESVL KAKAVVAFHR 60 GNFRELYKIL ESHQFSPHNH PKLQQLWLKA HYVEAEKLRG RPLGAVGKYR VRRKFPLPRT 120 IWDGEETSYC FKEKSRGVLR EWYAHNPYPS PREKRELAEA TGLTTTQVSN WFKNRRQRDR 180 AAEAKERENT ENNNSSSNKQ NQLSPLEGGK PLMSSSEEEF SPPQSPDQNS VLLLQSNMGH 240 ARSSNYSLPG LTASQPSHGL QAHQHQLQDS LLGPLTSSLV DLGS 284 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SIX1 | Q08DI4 | Bos taurus | Prediction | More>> | |||
| 1:1 ortholog | SIX1 | 490719 | J9P3S7 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | SIX1 | 106502564 | A0A452G009 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | SIX1 | 6495 | Q15475 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Six1 | 20471 | Q62231 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | SIX1 | 452952 | H2Q8E8 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | SIX1 | 100156847 | E5DCJ4 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | SIX1 | 100349440 | G1T717 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Six1 | 114634 | G3V970 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005730 | nucleolus |
| GO:0005654 | nucleoplasm |
| GO:0005634 | nucleus |
| GO:0005667 | transcription factor complex |
| GO:0003682 | chromatin binding |
| GO:0003677 | DNA binding |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0043565 | sequence-specific DNA binding |
| GO:0001223 | transcription coactivator binding |
| GO:0044212 | transcription regulatory region DNA binding |
| GO:0000976 | transcription regulatory region sequence-specific DNA binding |
| GO:0048856 | anatomical structure development |
| GO:0035909 | aorta morphogenesis |
| GO:0001658 | branching involved in ureteric bud morphogenesis |
| GO:1905243 | cellular response to 3,3',5-triiodo-L-thyronine |
| GO:0090103 | cochlea morphogenesis |
| GO:0048701 | embryonic cranial skeleton morphogenesis |
| GO:0048704 | embryonic skeletal system morphogenesis |
| GO:0030855 | epithelial cell differentiation |
| GO:0021610 | facial nerve morphogenesis |
| GO:0061197 | fungiform papilla morphogenesis |
| GO:0048699 | generation of neurons |
| GO:0048839 | inner ear development |
| GO:0042472 | inner ear morphogenesis |
| GO:0001822 | kidney development |
| GO:0072172 | mesonephric tubule formation |
| GO:0072075 | metanephric mesenchyme development |
| GO:0042474 | middle ear morphogenesis |
| GO:0051451 | myoblast migration |
| GO:0061055 | myotome development |
| GO:0043066 | negative regulation of apoptotic process |
| GO:0043524 | negative regulation of neuron apoptotic process |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0022008 | neurogenesis |
| GO:0048665 | neuron fate specification |
| GO:0030910 | olfactory placode formation |
| GO:0001759 | organ induction |
| GO:0071599 | otic vesicle development |
| GO:0003151 | outflow tract morphogenesis |
| GO:0007389 | pattern specification process |
| GO:0060037 | pharyngeal system development |
| GO:0090190 | positive regulation of branching involved in ureteric bud morphogenesis |
| GO:0090336 | positive regulation of brown fat cell differentiation |
| GO:2000729 | positive regulation of mesenchymal cell proliferation involved in ureter development |
| GO:0072513 | positive regulation of secondary heart field cardioblast proliferation |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| GO:0072107 | positive regulation of ureteric bud formation |
| GO:0034504 | protein localization to nucleus |
| GO:0072095 | regulation of branch elongation involved in ureteric bud branching |
| GO:0050678 | regulation of epithelial cell proliferation |
| GO:0010468 | regulation of gene expression |
| GO:0045664 | regulation of neuron differentiation |
| GO:0032880 | regulation of protein localization |
| GO:2001014 | regulation of skeletal muscle cell differentiation |
| GO:0014857 | regulation of skeletal muscle cell proliferation |
| GO:0014842 | regulation of skeletal muscle satellite cell proliferation |
| GO:0008582 | regulation of synaptic growth at neuromuscular junction |
| GO:0006355 | regulation of transcription, DNA-templated |
| GO:0007605 | sensory perception of sound |
| GO:0048741 | skeletal muscle fiber development |
| GO:0007519 | skeletal muscle tissue development |
| GO:0048705 | skeletal system morphogenesis |
| GO:0048538 | thymus development |
| GO:0030878 | thyroid gland development |
| GO:0043586 | tongue development |
| GO:0061551 | trigeminal ganglion development |
| GO:0072193 | ureter smooth muscle cell differentiation |
| GO:0001657 | ureteric bud development |