| Tag | Content |
|---|---|
| Uniprot ID | Q08DI4 |
| Entrez ID | |
| Genbank protein ID | AAI23734.1 |
| Genbank nucleotide ID | |
| Ensembl protein ID | |
| Ensembl nucleotide ID | |
| Gene name | SIX1 protein |
| Gene symbol | SIX1 |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | GVSRPFLFQR ALYSSSAYSA ASLQVLTRFY AFAQPREGVR SCRAPLPAAA SPCFFGFAPC 60 RVRPGSAPRQ APAMSMLPSF GFTQEQVACV CEVLQQGGNL ERLGRFLWSL PACDHLHKNE 120 SVLKAKAVVA FHRGNFRELY KILESHQFSP HNHPKLQQLW LKAHYVEAEK LRGRPLGAVG 180 KYRVRRKFPL PRTIWDGEET SYCFKEKSRG VLREWYAHNP YPSPREKREL AEATGLTTTQ 240 VSNWFKNRRQ RDRAAEAKER ENTENNNSSS NKQNQLSPLE GGKPLMSSSE EEFSPPQSPD 300 QNSVLLLQGN MGHARSSNYS LPGLTASQSA HSLQAHQHQL QDSLLGPLTS SLVDLGS 357 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SIX1 | Q08DI4 | Bos taurus | Prediction | More>> | |||
| 1:1 ortholog | SIX1 | 490719 | J9P3S7 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | SIX1 | 106502564 | A0A452G009 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | SIX1 | 6495 | Q15475 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Six1 | 20471 | Q62231 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | SIX1 | 452952 | H2Q8E8 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | SIX1 | 100156847 | E5DCJ4 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | SIX1 | 100349440 | G1T717 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Six1 | 114634 | G3V970 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0005667 | transcription factor complex |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0043565 | sequence-specific DNA binding |
| GO:0000976 | transcription regulatory region sequence-specific DNA binding |
| GO:0048856 | anatomical structure development |
| GO:0001658 | branching involved in ureteric bud morphogenesis |
| GO:0048701 | embryonic cranial skeleton morphogenesis |
| GO:0048704 | embryonic skeletal system morphogenesis |
| GO:0030855 | epithelial cell differentiation |
| GO:0048699 | generation of neurons |
| GO:0048839 | inner ear development |
| GO:0042472 | inner ear morphogenesis |
| GO:0001822 | kidney development |
| GO:0072172 | mesonephric tubule formation |
| GO:0072075 | metanephric mesenchyme development |
| GO:0051451 | myoblast migration |
| GO:0043524 | negative regulation of neuron apoptotic process |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0001759 | organ induction |
| GO:0007389 | pattern specification process |
| GO:0090190 | positive regulation of branching involved in ureteric bud morphogenesis |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| GO:0072107 | positive regulation of ureteric bud formation |
| GO:0072095 | regulation of branch elongation involved in ureteric bud branching |
| GO:0045664 | regulation of neuron differentiation |
| GO:0014857 | regulation of skeletal muscle cell proliferation |
| GO:0006355 | regulation of transcription, DNA-templated |
| GO:0048741 | skeletal muscle fiber development |
| GO:0007519 | skeletal muscle tissue development |
| GO:0048538 | thymus development |
| GO:0030878 | thyroid gland development |
| GO:0001657 | ureteric bud development |