| Tag | Content |
|---|---|
| Uniprot ID | E7FAU0 |
| Entrez ID | 100330952 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_009305009.2; XM_009305010.2; XM_002663432.5; XM_009305011.2; |
| Ensembl protein ID | ENSDARP00000079688 |
| Ensembl nucleotide ID | ENSDARG00000060482 |
| Gene name | E3 ubiquitin-protein ligase Midline-1 |
| Gene symbol | mid1 |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination. |
| Sequence | MDTLESELTC PICLELFEDP LLLPCAHSLC FHCAHRILTS HCAAFDESSK PPSAFQCPTC 60 RYVITLDQQG LDGLKRNVTL QNIIERFQKA SLSGPNSPTE TRKQISPSAM SSACEAVQCQ 120 FCEQDPPQEA VKTCVTCEVS YCQECLRATH PNKKPFTGHR LTEPVPDARL RGLACPEHGE 180 EKVNMYCITD EQLICSLCKL VGHHREHQVA SLGERYDKLK QMLDSNLSNL IKRNSELENL 240 MAKLIQTCQH VEHNAAHQES KLTEECDTLI NIVQQRRQII GTKIKEGKVV RLRKLAQQIA 300 NCKQFVERSS SLIIQADQAL KETDHARFLQ MAKSISERVS MATASSQVLI PEINLNDTFD 360 AFALDFSREK KMLEGLDYLT APNAPTIREE LCTASHDTIT VHWTSEDEFS VVSYELQYTI 420 STGQANVVSL CNSMDSWMIV PNIKQNHYTV HGLQSGTKYI FIVKAMNQAG SRSSPPGQLK 480 TNSQPFKLDP KSAHRKLKVS HDNLTVERDE ASSMKSHAQD RFGGTGNYGV TGNVYIDSGR 540 HYWEVLIGGS TWFAIGIAYK SAPKHGWVGK DSTSWVLSRC NTSWAVRHNS KEFPIEPSPH 600 MRRLGVLLDY DSGSLAFYDA AGTQHLYTFD IAFSQPICPV FSVWNKCLTV LTGLPIPDHL 660 EISDPHD 667 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MID1 | 534604 | E1BAD8 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | MID1 | 491737 | A0A5F4CNE1 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | MID1 | 102174822 | A0A452EDX1 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | MID1 | 100049999 | F7CLC3 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | MID1 | 4281 | O15344 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Mid1 | 17318 | O70583 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | MID1 | H2QYA1 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | MID1 | 100524415 | A0A5G2R4L4 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Mid1 | 54252 | P82458 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | mid1 | 100330952 | E7FAU0 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005874 | microtubule |
| GO:0008270 | zinc ion binding |
| InterPro ID | InterPro Term |
|---|---|
| IPR001870 | B30.2/SPRY |
| IPR043136 | B30.2/SPRY_sf |
| IPR003649 | Bbox_C |
| IPR003879 | Butyrophylin_SPRY |
| IPR013320 | ConA-like_dom_sf |
| IPR017903 | COS_domain |
| IPR003961 | FN3_dom |
| IPR036116 | FN3_sf |
| IPR013783 | Ig-like_fold |
| IPR027727 | MID1 |
| IPR040859 | Midline-1_COS |
| IPR003877 | SPRY_dom |
| IPR027370 | Znf-RING_LisH |
| IPR000315 | Znf_B-box |
| IPR001841 | Znf_RING |
| IPR013083 | Znf_RING/FYVE/PHD |
| IPR017907 | Znf_RING_CS |