Gene: MID1

Basic information

Tag Content
Uniprot ID F7CLC3
Entrez ID 100049999
Genbank protein ID
Genbank nucleotide ID XM_005613976.2; XM_005613975.2; XM_014728758.1;
Ensembl protein ID ENSECAP00000017531
Ensembl nucleotide ID ENSECAG00000019648
Gene name Midline 1
Gene symbol MID1
Organism Equus caballus
NCBI taxa ID 9796
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
METLESELTC PICLELFEDP LLLPCAHSLC FNCAHRILVS HCATNESVES ITAFQCPTCR 60
HVITLSQRGL DGLKRNVTLQ NIIDRFQKAS VSGPNSPSET RRERAFDANT MTSAEKVLCQ 120
FCDQDPAQDA VKTCVTCEVS YCDECLKATH PNKKPFTGHR LIEPIPDSHI RGLMCLEHED 180
ERVNMYCVTD DQLICALCKL VGRHRDHQVA ALSERYDKLK QNLESNLTSL IKRNTELETL 240
LAKLIQTCQH VEVNASRQEA KLMEECDLLI EIIQQRRQII GTKIKEGKVM RLRKLAQQIA 300
NCKQCIERSA SLISQAEHSL KENDHARFLQ TAKNITERVS MATASSQVLI PEINLNDTFD 360
TFALDFSREK KLLECLDYLT APNPPTIREE LCTASYDTIT VHWTSDDEFS VVSYELQYTI 420
FTGQANVVSL CNSADSWMIV PNIKQNHYTV HGLQSGTKYI FIVKAINQAG SRSSEPGKLK 480
TNSQPFKLDP KSAHRKLKVS HDNLTVERDE SSSKKSHTPE RFTSQGSYGV AGNVFIDSGR 540
HYWEVVISGS TWYAIGLAYK SAPKHEWIGK NSASWALCRC HNNWVVRHNS KEIPIEPAPH 600
LRRVGILLDY DNGSIAFYDA LNSIHLYTFD ITFSQPVCPT FTVWNKCLTI ITGLPIPDHL 660
DCTEQLP 667

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologMID1534604E1BAD8Bos taurusPredictionMore>>
1:1 orthologMID1491737A0A5F4CNE1Canis lupus familiarisPredictionMore>>
1:1 orthologMID1102174822A0A452EDX1Capra hircusPredictionMore>>
1:1 orthologMID1100049999F7CLC3Equus caballusPredictionMore>>
1:1 orthologMID14281O15344Homo sapiensPublicationMore>>
1:1 orthologMid117318O70583Mus musculusPredictionMore>>
1:1 orthologMID1H2QYA1Pan troglodytesPredictionMore>>
1:1 orthologMID1100524415A0A5G2R4L4Sus scrofaPredictionMore>>
1:1 orthologMid154252P82458Rattus norvegicusPredictionMore>>
1:1 orthologmid1100330952E7FAU0Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005881 cytoplasmic microtubule
GO:0008017 microtubule binding
GO:0051219 phosphoprotein binding
GO:0042803 protein homodimerization activity
GO:0031625 ubiquitin protein ligase binding
GO:0008270 zinc ion binding
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0035372 protein localization to microtubule

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0175 Coiled coil
KW-0479 Metal-binding
KW-1185 Reference proteome
KW-0862 Zinc
KW-0863 Zinc-finger

Interpro

InterPro ID InterPro Term
IPR001870 B30.2/SPRY
IPR043136 B30.2/SPRY_sf
IPR003649 Bbox_C
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR017903 COS_domain
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR027727 MID1
IPR040859 Midline-1_COS
IPR006574 PRY
IPR003877 SPRY_dom
IPR027370 Znf-RING_LisH
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS

PROSITE

PROSITE ID PROSITE Term
PS50188 B302_SPRY
PS51262 COS
PS50853 FN3
PS50119 ZF_BBOX
PS00518 ZF_RING_1
PS50089 ZF_RING_2

Pfam

Pfam ID Pfam Term
PF18568 COS
PF00041 fn3
PF13765 PRY
PF00622 SPRY
PF00643 zf-B_box
PF13445 zf-RING_UBOX