| Tag | Content |
|---|---|
| Uniprot ID | P82458 |
| Entrez ID | 54252 |
| Genbank protein ID | AAD56247.1 |
| Genbank nucleotide ID | NM_022927.1; XM_006256825.3; XM_017602143.1; XM_017602142.1; |
| Ensembl protein ID | ENSRNOP00000004873; ENSRNOP00000072598; |
| Ensembl nucleotide ID | ENSRNOG00000003613 |
| Gene name | E3 ubiquitin-protein ligase Midline-1 |
| Gene symbol | Mid1 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination. |
| Sequence | METLESELTC PICLELFEDP LLLPCAHSLC FNCAHRILVS HCATNEPVES INAFQCPTCR 60 HVITLSQRGL DGLKRNVTLQ NIIDRFQKAS VSGPNSPSET RRERAFDANT MSSAEKVLCQ 120 FCDQDPAQDA VKTCVTCEVS YCDECLKATH PNKKPFTGHR LIEPIPDSHI RGLMCLEHED 180 EKVNMYCVTD DQLICALCKL VGRHRDHQVA ALSERYDKLK QNLESNLTNL IKRNTELETL 240 LAKLIQTCQH VEVNASRQEA KLTEECDLLI EIIQERRQII GTKIKEGKVM RLRKLAQQIA 300 NCKQCIERSA SLISQAEHSL KENDHARFLQ TAKNITERVS MATASSQVLI PEINLNDTFD 360 TFALDFSREK KLLECLDYLT APNPPTIREE LCTASYDTIT VHWTSDDEFS VVSYELQYTI 420 FTGQANVVSL CNSADSWMIV PNIKQNHYTV HGLQSGTKYI FMVKAINQAG SRSSEPGKLK 480 TNSQPFKLDP KSAHRKLKVS HDNLTVERDE SSSKKSHTPE RFTSQGSYGV AGNVFIDSGR 540 HYWEVVISGS TWYAIGLAYK SAPKHEWIGK NSASWALCRC NNNWVVRHNS KEIPIEPAPH 600 PRRVGILLDY DNGSIAFYDA LNSIHLYTFD VALAQPVCPT FTVWNKCLTI ITGLPIPDHL 660 DCTEQLP 667 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MID1 | 534604 | E1BAD8 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | MID1 | 491737 | A0A5F4CNE1 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | MID1 | 102174822 | A0A452EDX1 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | MID1 | 100049999 | F7CLC3 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | MID1 | 4281 | O15344 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Mid1 | 17318 | O70583 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | MID1 | H2QYA1 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | MID1 | 100524415 | A0A5G2R4L4 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Mid1 | 54252 | P82458 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | mid1 | 100330952 | E7FAU0 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005881 | cytoplasmic microtubule |
| GO:0005874 | microtubule |
| GO:0015630 | microtubule cytoskeleton |
| GO:0019899 | enzyme binding |
| GO:0042802 | identical protein binding |
| GO:0008017 | microtubule binding |
| GO:0051219 | phosphoprotein binding |
| GO:0042803 | protein homodimerization activity |
| GO:0016740 | transferase activity |
| GO:0031625 | ubiquitin protein ligase binding |
| GO:0008270 | zinc ion binding |
| GO:0007026 | negative regulation of microtubule depolymerization |
| GO:0032874 | positive regulation of stress-activated MAPK cascade |
| GO:0035372 | protein localization to microtubule |
| InterPro ID | InterPro Term |
|---|---|
| IPR001870 | B30.2/SPRY |
| IPR043136 | B30.2/SPRY_sf |
| IPR003649 | Bbox_C |
| IPR003879 | Butyrophylin_SPRY |
| IPR013320 | ConA-like_dom_sf |
| IPR017903 | COS_domain |
| IPR003961 | FN3_dom |
| IPR036116 | FN3_sf |
| IPR013783 | Ig-like_fold |
| IPR027727 | MID1 |
| IPR040859 | Midline-1_COS |
| IPR006574 | PRY |
| IPR003877 | SPRY_dom |
| IPR027370 | Znf-RING_LisH |
| IPR000315 | Znf_B-box |
| IPR001841 | Znf_RING |
| IPR013083 | Znf_RING/FYVE/PHD |
| IPR017907 | Znf_RING_CS |