| Tag | Content |
|---|---|
| Uniprot ID | E9PTC3 |
| Entrez ID | 311071 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_006234145.3 |
| Ensembl protein ID | ENSRNOP00000072515; ENSRNOP00000006350; |
| Ensembl nucleotide ID | ENSRNOG00000004677 |
| Gene name | Zinc finger E-box-binding homeobox 2 |
| Gene symbol | Zeb2 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MKQPIMADGP RCKRRKQANP RRKNVVNYDN VVDAGSETDE EDKLHIAEDD GIANPLDQET 60 SPASMPNHES SPHMSQGLLP REEEEDEIRE SVVEHSWHSG EILQASVDGP EEMKEDYDAL 120 GPEATIQTTI NNGTVKNANC TSDFEEYFAK RKLEERDGHA VSIEEYLQRS DTAIIYPEAP 180 EELSRLGTPE ANGQEENDLP PGTPDAFAQL LTCPYCDRGY KRLTSLKEHI KYRHEKNEEN 240 FSCPLCSYTF AYRTQLERHM VTHKPGTDQH QMLTQGAGNR KFKCTECGKA FKYKHHLKEH 300 LRIHSGEKPY ECPNCKKRFS HSGSYSSHIS SKKCIGLISV NGRMRNNIKT GSSPNSVSSS 360 PTNSAITQLR NKLENGKPLS MSEQTGLLKI KTEPLDFNDY KVLMATHGFS GTSPFMNGGL 420 GATSPLGVHP SAQSPMQHLG VGLEAPLLGF PTMNSNLSEV QKVLQIVDNT VSRQKMDCKT 480 EDISKLKGYH MKDPCSQPEE QGVTSPSIPA VGLPVVSHNG ATKSIIDYTL EKVNEAKACL 540 QSLTTDSRRQ ISNIKKEKLR TLIDLVTDDK MIENHSIPTP FSCQFCKESF PGPIPLHQHE 600 RYLCKMNEEI KAVLQPHENI VPNKAGVFVD NKALLLSSVL SEKGLTSPIN PYKDHMSVLK 660 AYYAMNMEPN SDELLKISIA VGLPQEFVKE WFEQRKVYQY SSSRSPSLER NSKPLAPNSN 720 PTTKDSLLPR SPVKPMDSIT SPSIAELHNS VTSCDPPLRL TKSSHFTNIK AVDKLDHSRS 780 NTPSPLNLSS TSSKNSHSSS YTPNSFSSEE LQAEPLDLSL PKQMREPKSI IATKNKTKAT 840 SISLDHNSVS SSSENSDEPL NLTFIKKEFS NSNNLDNKST NPVFGMNPFS AKPLYTALPP 900 QSAFPPATFM PPVQTSIPGL RPYPGLDQMS FLPHMAYTYP TGAATFADMQ QRRKYQRKQG 960 FQGELLDGAQ DYMSGLDDLT DSDSCLSRKK IKKTESGMYA CDLCDKTFQK SSSLLRHKYE 1020 HTGKRPHQCQ ICKKAFKHKH HLIEHSRLHS GEKPYQCDKC GKRFSHSGSY SQHMNHRYSY 1080 CKREAEEREA AEREAREKGH LEPTELLMNR AYLQSITPQG YSDSEERESM PRDGESEKEH 1140 EKEGEEGYGK LRRRDGDEEE EEEEEESENK SMDTDPETIR DEEETGDHSM DDSSEDGKME 1200 TKSDHEEDNM EDGME 1215 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ZEB2 | 102190273 | A0A452FGS1 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | ZEB2 | A0A1B0GV02 | Homo sapiens | Prediction | More>> | |||
| 1:1 ortholog | Zeb2 | 24136 | Q9R0G7 | CPO | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | ZEB2 | 459644 | H2QIS9 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | A0A4X1TCF8 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | Zeb2 | 311071 | E9PTC3 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005829 | cytosol |
| GO:0000790 | nuclear chromatin |
| GO:0005730 | nucleolus |
| GO:0005654 | nucleoplasm |
| GO:0005634 | nucleus |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| GO:0070412 | R-SMAD binding |
| GO:0043565 | sequence-specific DNA binding |
| GO:0021846 | cell proliferation in forebrain |
| GO:0007417 | central nervous system development |
| GO:0048668 | collateral sprouting |
| GO:0021540 | corpus callosum morphogenesis |
| GO:0021957 | corticospinal tract morphogenesis |
| GO:0048066 | developmental pigmentation |
| GO:0048598 | embryonic morphogenesis |
| GO:0021766 | hippocampus development |
| GO:0061373 | mammillary axonal complex development |
| GO:0097324 | melanocyte migration |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0001755 | neural crest cell migration |
| GO:0001843 | neural tube closure |
| GO:0050772 | positive regulation of axonogenesis |
| GO:0043507 | positive regulation of JUN kinase activity |
| GO:1902748 | positive regulation of lens fiber cell differentiation |
| GO:0045636 | positive regulation of melanocyte differentiation |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0030177 | positive regulation of Wnt signaling pathway |
| GO:1903056 | regulation of melanosome organization |
| GO:0001756 | somitogenesis |