Gene: Zeb2

Basic information

Tag Content
Uniprot ID Q9R0G7; Q6P9M5;
Entrez ID 24136
Genbank protein ID AAH60699.1; AAD56590.1;
Genbank nucleotide ID XM_017318065.1; XM_011239102.2; NM_015753.4; XM_017318061.1; NM_001289521.1; XM_017318063.1;
Ensembl protein ID ENSMUSP00000069685; ENSMUSP00000134849; ENSMUSP00000134747;
Ensembl nucleotide ID ENSMUSG00000026872
Gene name Zinc finger E-box-binding homeobox 2
Gene symbol Zeb2
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage E14.5
Data sources Manually collected
Reference 16598713
Functional description Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin.
Sequence
MKQPIMADGP RCKRRKQANP RRKNVVNYDN VVDAGSETDE EDKLHIAEDD SLANPLDQDT 60
SPASMPNHES SPHMSQGLLP REEEEEELRE SVVEHSWHSG EILQASVAGP EEMKEDYDAM 120
GPEATIQTTI NNGTVKNANC TSDFEEYFAK RKLEERDGHA VSIEEYLQRS DTAIIYPEAP 180
EELSRLGTPE ANGQEENDLP PGTPDAFAQL LTCPYCDRGY KRLTSLKEHI KYRHEKNEEN 240
FSCPLCSYTF AYRTQLERHM VTHKPGTDQH QMLTQGAGNR KFKCTECGKA FKYKHHLKEH 300
LRIHSGEKPY ECPNCKKRFS HSGSYSSHIS SKKCIGLISV NGRMRNNIKT GSSPNSVSSS 360
PTNSAITQLR NKLENGKPLS MSEQTGLLKI KTEPLDFNDY KVLMATHGFS GSSPFMNGGL 420
GATSPLGVHP SAQSPMQHLG VGMEAPLLGF PTMNSNLSEV QKVLQIVDNT VSRQKMDCKT 480
EDISKLKGYH MKDPCSQPEE QGVTSPNIPP VGLPVVSHNG ATKSIIDYTL EKVNEAKACL 540
QSLTTDSRRQ ISNIKKEKLR TLIDLVTDDK MIENHSISTP FSCQFCKESF PGPIPLHQHE 600
RYLCKMNEEI KAVLQPHENI VPNKAGVFVD NKALLLSSVL SEKGLTSPIN PYKDHMSVLK 660
AYYAMNMEPN SDELLKISIA VGLPQEFVKE WFEQRKVYQY SNSRSPSLER TSKPLAPNSN 720
PTTKDSLLPR SPVKPMDSIT SPSIAELHNS VTSCDPPLRL TKSSHFTNIK AVDKLDHSRS 780
NTPSPLNLSS TSSKNSHSSS YTPNSFSSEE LQAEPLDLSL PKQMREPKGI IATKNKTKAT 840
SINLDHNSVS SSSENSDEPL NLTFIKKEFS NSNNLDNKSN NPVFGMNPFS AKPLYTPLPP 900
QSAFPPATFM PPVQTSIPGL RPYPGLDQMS FLPHMAYTYP TGAATFADMQ QRRKYQRKQG 960
FQGDLLDGAQ DYMSGLDDMT DSDSCLSRKK IKKTESGMYA CDLCDKTFQK SSSLLRHKYE 1020
HTGKRPHQCQ ICKKAFKHKH HLIEHSRLHS GEKPYQCDKC GKRFSHSGSY SQHMNHRYSY 1080
CKREAEEREA AEREAREKGH LEPTELLMNR AYLQSITPQG YSDSEERESM PRDGESEKEH 1140
EKEGEEGYGK LRRRDGDEEE EEEEEESENK SMDTDPETIR DEEETGDHSM DDSSEDGKME 1200
TKSDHEEDNM EDGME 1215

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression during embryonic days (E11.5~E18.5) ~ adult days (Ps) in the lip and palate tissues. (X-axis: days, Y-axis: tissues)

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Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologZEB2102190273A0A452FGS1Capra hircusPredictionMore>>
1:1 orthologZEB2A0A1B0GV02Homo sapiensPredictionMore>>
1:1 orthologZeb224136Q9R0G7CPOE14.5Mus musculusPublicationMore>>
1:1 orthologZEB2459644H2QIS9Pan troglodytesPredictionMore>>
1:1 orthologA0A4X1TCF8Sus scrofaPredictionMore>>
1:1 orthologZeb2311071E9PTC3Rattus norvegicusPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specificISO
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specificIMP
GO:0043565 sequence-specific DNA bindingISO
GO:0046872 metal ion bindingIEA
GO:0070412 R-SMAD bindingIDA

GO:Biological Process

GO ID GO Term Evidence
GO:0000122 negative regulation of transcription by RNA polymerase IIISO
GO:0000122 negative regulation of transcription by RNA polymerase IIIMP
GO:0001755 neural crest cell migrationIMP
GO:0001756 somitogenesisIMP
GO:0001843 neural tube closureIMP
GO:0007417 central nervous system developmentIGI
GO:0021540 corpus callosum morphogenesisIMP
GO:0021766 hippocampus developmentIMP
GO:0021846 cell proliferation in forebrainIMP
GO:0021957 corticospinal tract morphogenesisIMP
GO:0030177 positive regulation of Wnt signaling pathwayIMP
GO:0043507 positive regulation of JUN kinase activityIMP
GO:0045636 positive regulation of melanocyte differentiationIMP
GO:0045944 positive regulation of transcription by RNA polymerase IIISO
GO:0045944 positive regulation of transcription by RNA polymerase IIIMP
GO:0048023 positive regulation of melanin biosynthetic processIC
GO:0048066 developmental pigmentationIMP
GO:0048598 embryonic morphogenesisIGI
GO:0048668 collateral sproutingIMP
GO:0050772 positive regulation of axonogenesisIMP
GO:0061373 mammillary axonal complex developmentIMP
GO:0097324 melanocyte migrationIMP
GO:1902748 positive regulation of lens fiber cell differentiationIMP
GO:1903056 regulation of melanosome organizationIMP

GO:Cellular Component

GO ID GO Term Evidence
GO:0000790 nuclear chromatinISO
GO:0005634 nucleusISO
GO:0005634 nucleusIDA
GO:0005654 nucleoplasmISO
GO:0005730 nucleolusISO
GO:0005829 cytosolISO

Reactome Pathway

Reactome ID Reactome Term Evidence

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0007 Acetylation
KW-0238 DNA-binding
KW-0371 Homeobox
KW-1017 Isopeptide bond
KW-0479 Metal-binding
KW-0539 Nucleus
KW-0597 Phosphoprotein
KW-1185 Reference proteome
KW-0677 Repeat
KW-0678 Repressor
KW-0804 Transcription
KW-0805 Transcription regulation
KW-0832 Ubl conjugation
KW-0862 Zinc
KW-0863 Zinc-finger

Interpro

InterPro ID InterPro Term
IPR008598 Di19_Zn_binding_dom
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

PROSITE

PROSITE ID PROSITE Term
PS00028 ZINC_FINGER_C2H2_1
PS50157 ZINC_FINGER_C2H2_2

Pfam

Pfam ID Pfam Term
PF00096 zf-C2H2
PF05605 zf-Di19

Protein-protein interaction

Protein-miRNA interaction