| Tag | Content |
|---|---|
| Uniprot ID | E9Q2Z1; E9QA25; F6VR46; F7B218; Q6PAQ2; Q6ZPI9; |
| Entrez ID | 330409 |
| Genbank protein ID | BAC98245.1; AAH60152.1; |
| Genbank nucleotide ID | XM_006506320.1; NM_001128151.1; |
| Ensembl protein ID | ENSMUSP00000098556; ENSMUSP00000108306; |
| Ensembl nucleotide ID | ENSMUSG00000071226 |
| Gene name | Cat eye syndrome critical region protein 2 homolog |
| Gene symbol | Cecr2 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 20589882 |
| Functional description | Chromatin reader component of histone-modifying complexes, such as the CERF (CECR2-containing-remodeling factor) complex and ISWI-type complex (By similarity). It thereby plays a role in various processes during development: required during embryogenesis for neural tube closure and inner ear development (PubMed:15640247, PubMed:20589882, PubMed:21246654). In adults, required for spermatogenesis, via the formation of ISWI-type chromatin complexes (PubMed:22154806). In histone-modifying complexes, CECR2 recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated (By similarity). May also be involved through its interaction with LRPPRC in the integration of cytoskeletal network with vesicular trafficking, nucleocytosolic shuttling, transcription, chromosome remodeling and cytokinesis (By similarity). |
| Sequence | MCPEEGGAAG LGELRSWWEV PAIAHFCSLF RTAFRLPDFE IEELEAALHR DDVEFISDLI 60 ACLLQGCYQR RDITPQTFHS YLEDIINYRW ELEEGKPNPL REASFQDLPL RTRVEILHRL 120 CDYRLDADDV FDLLKGLDAD SLRVEPLGED NSGALYWYFY GTRMYKEDPV QGRSNGELSL 180 CRESERQKNV SNVPGKTGKR RGRPPKRKKL QEEIISSEKQ EENSLTSDLQ TRNGSRGPGQ 240 GTWWLLCQTE EEWRQVTESF RERTSLRERQ LYKLLSEDFL PEICNMIAQK GKRPQRTKPE 300 LQHRFMSDHL SIKSIKLEET PMLTKIEKQK RREEEEERQL LLAVQKKEQE QMLKEERKRE 360 MEEKVKAVED RAKRRKLREE RAWLLAQGKE LPPELSHLDL NSPMREGKKT KDLFELDDDF 420 TAMYKVLDVV KAHKDSWPFL EPVDESYAPN YYQIIKIPMD ISSMEKKLNG GLYCNKEEFV 480 NDMKTMFRNC RKYNGDSSEY TKMSDNLERC FHRAMTKHFP GEDGDTDEEF WIKEDEKREK 540 RRSRSGRSSG SHVWTRSRDT EGSSRKQPPV ENGGKSLPPA RRAASSGDDQ SRSSIQLPPE 600 VGTSHGQGFS RPLHCGRVPS HAPPLNQMRP AAPGTFGSLQ GSDPTNLHGS SRIPEAPPGE 660 PLQHPPFAIQ APVGISNHRG SLLSAPDLSN MGSHVPSLQL GQMNCPSQDG NMYPPAPFQA 720 GFIPSRHGGT PARPPDFPES SEIPPGHIYH SYKYLNRAHP AVWNGNHGTT NPGRLGPDEK 780 PHLGPGPSHH PHTLGHMMDG RVMRQPIPPN QWTKQSSFLP HGVPSSGYMQ PPCKSAGHRL 840 QPPPTPAPSP RFRGPSQALR GAQGGESMMD SPEMIAMQQL SSRVCPPGVP YHPRQPTPPQ 900 LPGPFPQVAH SASVCVSAPK PALDNPGSTQ EMTETHEPEE DPAEPLPGHE EKAASICSSE 960 GVYLKQLPHP APPLQASCTR QSSPQERETE DSQLKSDASD SADTYKTSKN KNTWPLDNSY 1020 SSPAVQGCLR DLSIVAETGN LPENGVVGEA SPCRSEGKGL DGSGSEKPLC PRGKTLQEAV 1080 PCTGPNATTP PCTDPSLMAA TVNQFSPLYM PGIEYSNSAT QYPMSPSLQG LASMMGGKSS 1140 GSQPQSFPPR GFQANGPHPG LFPRYRPQQG MRYSYQPPSQ PSYHPYQRTP YYTCPQGFSD 1200 WQRSLPSQRS PSGPPGSHPP RSLFSEKNVL SSLQGCETLN TALTSPTQMD VVTAKVVPPD 1260 GHNSGPEEEK MDESVERPES PKEFLDLDNH NAATKRQNSL STSDYLYGTP PPSLSSGMTF 1320 GSSAFPPHSV MLQTGSPYTP QRSASHFQPR AYPSPVPAHP PPHPVATQPN GLSPEDSLYC 1380 CQEEGLGHFQ ASMMEQTGTG SGLRGSFQEV HRPPGLQMHP VQSQSLFPKT PAPAASPEQL 1440 PPHKTPTLPL DQS 1453 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | CECR2 | A0A452ELZ1 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | CECR2 | 27443 | Q9BXF3 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Cecr2 | 330409 | E9Q2Z1 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | CECR2 | 470135 | A0A2I3SEK4 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | CECR2 | 100356626 | G1SS27 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Cecr2 | 500308 | F1LYI0 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0003674 | molecular_function | ND |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001842 | neural fold formation | IMP |
| GO:0001843 | neural tube closure | IMP |
| GO:0001843 | neural tube closure | IGI |
| GO:0007338 | single fertilization | IMP |
| GO:0021915 | neural tube development | IMP |
| GO:0043044 | ATP-dependent chromatin remodeling | ISO |
| GO:0060122 | inner ear receptor cell stereocilium organization | IMP |
| GO:0090102 | cochlea development | IMP |
| GO:0097194 | execution phase of apoptosis | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005634 | nucleus | ISO |
| GO:0005719 | nuclear euchromatin | IDA |
| GO:0031010 | ISWI-type complex | IPI |
| GO:0090537 | CERF complex | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|
| Pfam ID | Pfam Term |
|---|---|
| PF00439 | Bromodomain |