| Tag | Content |
|---|---|
| Uniprot ID | F1M2B7 |
| Entrez ID | 304729 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_008769455.2; XM_017598784.1; |
| Ensembl protein ID | ENSRNOP00000009963 |
| Ensembl nucleotide ID | ENSRNOG00000007261 |
| Gene name | GLI family zinc finger 2 |
| Gene symbol | Gli2 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | METSAQAPAL EKKEAKSGLL EDSSFPDPGK KACPLAVAAP AAAVAAQGVP QQLLPSFHVP 60 LPIDMRHQEG RYHYDPHPVH GVHGPPTLSG SPVISDISLI RLSPHPAGPG ESPFSAHHPY 120 MNPHMEHYLR SVHSSPTLSM ISAARGLSPA DVAHEHLKER GLFSLAAPGT NPSDYYHQMT 180 LMASHPTPYG DILMQSGGAA SAPHLHDYLN PVDASRFSSP RVTPRLSRKR ALSISPLSDA 240 SLDLQRMIRT SPNSLVAYIN NSRSSSAASG SYGHLSAGAL SPAFTFPHPI NPVAYQQILS 300 QQRGLGSAFG HTPPLIQPSP TFLAQQPMTL TSITVPTQLG SNSSNCISDA NQNKQNSESA 360 VSSTVNPITI HKRSKVKTEA EGLRPASPLG LTQEQLADLK EDLDRDDCKQ EAEVVIYETN 420 CHWADCTKEY DTQEQLVHHI NNEHIHGEKK EFVCRWQACT REQKPFKAQY MLVVHMRRHT 480 GEKPHKCTFE GCSKAYSRLE NLKTHLRSHT GEKPYVCEHE GCNKAFSNAS DRAKHQNRTH 540 SNEKPYICKI PGCTKRYTDP SSLRKHVKTV HGPDAHVTKK QRNDVHLRAP LLKENGDNEA 600 GAEPGGRGPE ESVEASSTSH TAEDCLHIKA IKTESSGLCQ SSPGAQSSCS SEPSPLGSVP 660 NNDSGVEMPG TGPGSLGDLT ALDDTSPGAD TSALAVPSTG GLQLRKHMTT MHRFEQLKRE 720 KLKSLKDSCS WAGPAPHTRN TKLPPLPVNG SVLENFNNTG GCGPAGLLPN QRLPELTEVT 780 MLSQLQERRD SSTSTMSSAY TVSRRSSGIS PYFSSRRSSE ASPLGGIRPH NASSADSYDP 840 ISTDASRRSS EASQCSGGGP GLLNLTPAQQ YSLRAKYAAA TGGPPPTPLP GLDRVSLRTR 900 LALLDAPERA LPGACPQPLG PRRGSDGPTY NHGHGYVGAA PALPHEGPNG STRRASDPVR 960 RPDPLVLPRV QRFHSIHNMN PGPLPPCTDR RGLHLQSHPS VDGSLTRHAY SPRPPSINEN 1020 VVMEAVAAGV EGAGLESDLG LVEDDLVLPD DVVQYIKAHT GGALDDSTRQ VYPTEGTGFP 1080 ENSKLPSPGL QGHRRLAAAD SNMSPSAPGL GGCQLSYSPS SSLNKSNMPV QWNEVSSGTV 1140 DALPTQVKPP SFPQSNLVQQ KPAFAHYPGY SPQALQSGSG GLDSTQPHLQ LRGAPSASRG 1200 SYTQQPRLPA TGSQCLGVTA AMSPQANYSQ THHQLSPNVV SGSLNQFAPS CSNMAAKPSH 1260 LGLPQQMEVV PNATIISGHQ RELGIASSSL AAVSQPHPVL GYPQQDGYQQ VSGLPSSHQP 1320 SFMESQQNTG FGLMQPRPPL EPNTASRHRG VRSGQQQQQL YARTAGQAVV TSANQETAEA 1380 MPKGTAGTVV SLTPQPSQDT GRSQDQNTLY YYGQIHMYEQ NGGCPAMQPQ PPQPQGCSDN 1440 IQPEPLPSPG VNQVSSTVDS QLLEPPQIDF DAIMDDGDHS SLFSGALSPS LLHNLSQNSS 1500 RLTTPRNSLT LPSIPVGISN MAVGDMSSML TSLAEENKFL NMMT 1544 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | GLI2 | 102178402 | A0A452F0Y2 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | GLI2 | 2736 | P10070 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Gli2 | 14633 | Q0VGT2 | CPO | E11.5, E13.0, E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | GLI2 | A0A2I3SWC0 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | GLI2 | 100520334 | F1RXX4 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | GLI2 | G1SDR5 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Gli2 | 304729 | F1M2B7 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005930 | axoneme |
| GO:0097542 | ciliary tip |
| GO:0005929 | cilium |
| GO:0005737 | cytoplasm |
| GO:0016020 | membrane |
| GO:0031514 | motile cilium |
| GO:0016607 | nuclear speck |
| GO:0005634 | nucleus |
| GO:0003682 | chromatin binding |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:1990841 | promoter-specific chromatin binding |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| GO:0043565 | sequence-specific DNA binding |
| GO:0008134 | transcription factor binding |
| GO:0044212 | transcription regulatory region DNA binding |
| GO:0008270 | zinc ion binding |
| GO:0048856 | anatomical structure development |
| GO:0048646 | anatomical structure formation involved in morphogenesis |
| GO:0009952 | anterior/posterior pattern specification |
| GO:0007411 | axon guidance |
| GO:0048754 | branching morphogenesis of an epithelial tube |
| GO:0030154 | cell differentiation |
| GO:0071407 | cellular response to organic cyclic compound |
| GO:0098586 | cellular response to virus |
| GO:0021696 | cerebellar cortex morphogenesis |
| GO:0002062 | chondrocyte differentiation |
| GO:0090103 | cochlea morphogenesis |
| GO:0048589 | developmental growth |
| GO:0021904 | dorsal/ventral neural tube patterning |
| GO:0009953 | dorsal/ventral pattern formation |
| GO:0048566 | embryonic digestive tract development |
| GO:0042733 | embryonic digit morphogenesis |
| GO:0009913 | epidermal cell differentiation |
| GO:0021508 | floor plate formation |
| GO:0031069 | hair follicle morphogenesis |
| GO:0060322 | head development |
| GO:0007507 | heart development |
| GO:0030902 | hindbrain development |
| GO:0007442 | hindgut morphogenesis |
| GO:0001701 | in utero embryonic development |
| GO:0001822 | kidney development |
| GO:0030324 | lung development |
| GO:0030879 | mammary gland development |
| GO:0060603 | mammary gland duct morphogenesis |
| GO:0002009 | morphogenesis of an epithelium |
| GO:0043066 | negative regulation of apoptotic process |
| GO:0032331 | negative regulation of chondrocyte differentiation |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0021915 | neural tube development |
| GO:0048666 | neuron development |
| GO:0060032 | notochord regression |
| GO:0042475 | odontogenesis of dentin-containing tooth |
| GO:0002076 | osteoblast development |
| GO:0001649 | osteoblast differentiation |
| GO:0007389 | pattern specification process |
| GO:0021983 | pituitary gland development |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:0045740 | positive regulation of DNA replication |
| GO:0045666 | positive regulation of neuron differentiation |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| GO:0030850 | prostate gland development |
| GO:0060513 | prostatic bud formation |
| GO:0009954 | proximal/distal pattern formation |
| GO:0009612 | response to mechanical stimulus |
| GO:0001501 | skeletal system development |
| GO:0007224 | smoothened signaling pathway |
| GO:0060831 | smoothened signaling pathway involved in dorsal/ventral neural tube patterning |
| GO:0021938 | smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation |
| GO:0021776 | smoothened signaling pathway involved in spinal cord motor neuron cell fate specification |
| GO:0021775 | smoothened signaling pathway involved in ventral spinal cord interneuron specification |
| GO:0021513 | spinal cord dorsal/ventral patterning |
| GO:0021522 | spinal cord motor neuron differentiation |
| GO:0021965 | spinal cord ventral commissure morphogenesis |
| GO:0035295 | tube development |
| GO:0007418 | ventral midline development |
| GO:0021517 | ventral spinal cord development |
| Pfam ID | Pfam Term |
|---|---|
| PF00096 | zf-C2H2 |