| Tag | Content |
|---|---|
| Uniprot ID | F1RXX4; A0A068A0B0; |
| Entrez ID | 100520334 |
| Genbank protein ID | AHZ64986.1 |
| Genbank nucleotide ID | XM_005671643.2; NM_001315712.1; |
| Ensembl protein ID | ENSSSCP00000016673 |
| Ensembl nucleotide ID | ENSSSCG00000015733 |
| Gene name | GLI family zinc finger 2 |
| Gene symbol | GLI2 |
| Organism | Sus scrofa |
| NCBI taxa ID | 9823 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MEASASVPAA EKKEAKSGIL EGIAFPEPGR KASALAVAAA VAAQGVPQHL LPPFHAPLPL 60 DMRHQEGRYH YEPHSVHGVP GPPALSGSPV VSDISLIRLS PHPAGPGESP FNAPHPYVSP 120 HMEHYLRAMH GSPTLPAIPA ARGLSPADVA HEHLKERGLF GLPAPGANAS DYYHQMTLMA 180 GHPTPYGDLL MQSGGAASAP HLHDYLNPVD MSRFSSPRVT PRLSRKRALS ISPLSDASLD 240 LQRMIRTSPN SLVAYINNSR SSSAASGSYG HLSAGALSPA FTFPHPINPV AYQQILSQQR 300 GLGSAFGHTP PLIQPSPTFL AQQPLAVASI NATPTQLSSS SNCLSDANQN KQSSESAVSS 360 TINPMVIHKR SKVKTEAEGL RPASPLTLTQ EQLADLKEDL DRDDCKQEAE VVIYETNCHW 420 EDCTKEYDTQ EQLVHHINNE HIHGEKKEFV CRWQACTREQ KPFKAQYMLV VHMRRHTGEK 480 PHKCTFEGCS KAYSRLENLK THLRSHTGEK PYVCEHEGCN KAFSNASDRA KHQNRTHSNE 540 KPYICKIPGC TKRYTDPSSL RKHVKTVHGP DAHVTKKQRN DVHLRAPLLR ENGDSEAGAE 600 PGRGSEDSTE ASSTSQAVED CLHVKAIKTE SSGLCQSSPG AQSSCSSEPS PLGSAPNNDS 660 GVEMPGTGPG SLGDLTALDD TPPGADASAL AAPSAGGLQL RKHMTAMHRF EQLKKEKLKS 720 LKDSCSWAGP APHTRNSKLP PLPGSGSMLE NFSGGPVGLL PNPRLSELSA SEVTVLSHLQ 780 ERRDSSTSTV SSAYTVSRRS SGSSPYFSSR RSSDASPLGP GRANPASSAD SYDPISTDAS 840 RRSSEASQCG GAGGPGLLQL TPAQQYSLRA KYAAATGGPP PTPLPGLERA SLRARLALLD 900 APERAPPAAC PRPVGVGLRR GSDGPHYGPT GVAPTFPHEG PGGGLRRASD PGRRPDALAP 960 PRVQRFHSAH NMAPAALPPT CTQGRGLRLQ GHASADGGLA RSAYSPRPPS ISEDLVMEAV 1020 AAAADSAGPE ISLGLPEDDL VLPDDVVQYI KARAGGALEE STPQVYAPES TCFPENPKLP 1080 SPGLPSQRRI AAADSNVGPS APALGGCQLG YGAPSSLNKN SMPVQWNEVS SGTVDALASQ 1140 MKPPPFPQGN LAVVQQKPAF SQYPGYSPQG LQPSPGSLDS SQPHLQPCGG APSALRVNYM 1200 HQLRQPGAGG QCPSMTAAVS PHTGYSQAHP QLSPSTMGGT LNQFPTSCSN MAAKPGHLGF 1260 PQQMEVAPDP TMMGSNNREL GIPNSTLPGM PPTHAAQSYP QQSHLLATAM SQEGYRQGPS 1320 LMPSHQPSFM EPQQGTMGVA GSSFGLVQPR PPPEPSPAGR HRGVRAGQQL AYARATGHAM 1380 AALSANQEMA ESVPKGTMLS LPPQPPAQDT GGAQDHSMLY YYGQIHMYEQ NGGLERQAGC 1440 QAMQPQPPQP QALPSPGVNQ VSSTVDSQLL EAPQIDFDAI MDDGDHSSLL SGALSPGLLH 1500 SLSQSSSRLT TPRNSLTLPS IPAGISNMAV GDMSSMLTSL AEESKFLNMI T 1551 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | GLI2 | 102178402 | A0A452F0Y2 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | GLI2 | 2736 | P10070 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Gli2 | 14633 | Q0VGT2 | CPO | E11.5, E13.0, E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | GLI2 | A0A2I3SWC0 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | GLI2 | 100520334 | F1RXX4 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | GLI2 | G1SDR5 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Gli2 | 304729 | F1M2B7 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005930 | axoneme |
| GO:0097542 | ciliary tip |
| GO:0016020 | membrane |
| GO:0031514 | motile cilium |
| GO:0016607 | nuclear speck |
| GO:0005730 | nucleolus |
| GO:0005634 | nucleus |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:1990841 | promoter-specific chromatin binding |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| GO:0008134 | transcription factor binding |
| GO:0008270 | zinc ion binding |
| GO:0009952 | anterior/posterior pattern specification |
| GO:0007411 | axon guidance |
| GO:0048754 | branching morphogenesis of an epithelial tube |
| GO:0071407 | cellular response to organic cyclic compound |
| GO:0021696 | cerebellar cortex morphogenesis |
| GO:0002062 | chondrocyte differentiation |
| GO:0090103 | cochlea morphogenesis |
| GO:0048589 | developmental growth |
| GO:0048566 | embryonic digestive tract development |
| GO:0042733 | embryonic digit morphogenesis |
| GO:0021508 | floor plate formation |
| GO:0031069 | hair follicle morphogenesis |
| GO:0007507 | heart development |
| GO:0007442 | hindgut morphogenesis |
| GO:0001701 | in utero embryonic development |
| GO:0001822 | kidney development |
| GO:0030324 | lung development |
| GO:0060603 | mammary gland duct morphogenesis |
| GO:0043066 | negative regulation of apoptotic process |
| GO:0032331 | negative regulation of chondrocyte differentiation |
| GO:0045879 | negative regulation of smoothened signaling pathway |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0060032 | notochord regression |
| GO:0042475 | odontogenesis of dentin-containing tooth |
| GO:0002076 | osteoblast development |
| GO:0021983 | pituitary gland development |
| GO:0045740 | positive regulation of DNA replication |
| GO:0045666 | positive regulation of neuron differentiation |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0060513 | prostatic bud formation |
| GO:0009954 | proximal/distal pattern formation |
| GO:0007224 | smoothened signaling pathway |
| GO:0060831 | smoothened signaling pathway involved in dorsal/ventral neural tube patterning |
| GO:0021938 | smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation |
| GO:0021776 | smoothened signaling pathway involved in spinal cord motor neuron cell fate specification |
| GO:0021775 | smoothened signaling pathway involved in ventral spinal cord interneuron specification |
| GO:0021965 | spinal cord ventral commissure morphogenesis |
| Pfam ID | Pfam Term |
|---|---|
| PF00096 | zf-C2H2 |