Gene: NECTIN1

Basic information

Tag Content
Uniprot ID F1PCB6
Entrez ID 489363
Genbank protein ID
Genbank nucleotide ID NM_001287128.1
Ensembl protein ID ENSCAFP00000017680
Ensembl nucleotide ID ENSCAFG00000012012
Gene name Uncharacterized protein
Gene symbol NECTIN1
Organism Canis lupus familiaris
NCBI taxa ID 9615
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MARMGLAGAA GRWWGLALGL TAFFLPGTDA QVVQVNDSMY GFIGTDVVLH CSFTNPLPSV 60
KITQVTWQKA TNGSKQNVAI YNPAMGVSVL APYRERVEFL RPSFTDGTIR LSRLELDDEG 120
VYICEFATFP AGNRESQLNL TVMAKPTNWV EGTQAVLRAK KGQDDKVLVA TCTSANGKPP 180
SVVSWETRLK GEAEYQEIRN PNGTVTVISR YRLVPSREAH QQSLACIVNY HMDRFRESLT 240
LNVQYEPEVT IEGFDGNWYL QRMDVKLTCK ADANPPATEY HWTTLNGSLP KGVEAQNRTL 300
FFRGPINYSL AGTYVCEATN PIGTRSGQVE VNITEFPYTP SPPEHGRRAG PVPTAIIGGV 360
AGSILLVAIV VGGIVVALRR RRHTFKGDYS TKKHVYGNGY SKAGIPQHHP PMAQNLQYPD 420
DSDDEKKPGP LGGSSYEEEE EEEGGGGGER KVGGPHPKYD EDAKRPYFTV DEAEARQDGY 480
GDRTLGYQYD PEQLDLAENM VSQNDGSFIS KKEWYV 516

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologNECTIN1489363F1PCB6Canis lupus familiarisPredictionMore>>
1:1 orthologNECTIN1A0A452G6R9Capra hircusPredictionMore>>
1:1 orthologNECTIN15818Q15223Homo sapiensPublicationMore>>
1:1 orthologNectin158235Q9JKF6E15.0Mus musculusPredictionMore>>
1:1 orthologNECTIN1H2Q4Y8Pan troglodytesPredictionMore>>
1:1 orthologNECTIN1F1S9T5Sus scrofaPredictionMore>>
1:1 orthologNectin1192183F1LNP8Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005912 adherens junction
GO:0043296 apical junction complex
GO:0044291 cell-cell contact zone
GO:0098686 hippocampal mossy fiber to CA3 synapse
GO:0099059 integral component of presynaptic active zone membrane
GO:0050839 cell adhesion molecule binding
GO:0042803 protein homodimerization activity
GO:0038023 signaling receptor activity
GO:0002934 desmosome organization
GO:0070166 enamel mineralization
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
GO:0006826 iron ion transport
GO:0002089 lens morphogenesis in camera-type eye
GO:1902414 protein localization to cell junction
GO:0051963 regulation of synapse assembly
GO:0060041 retina development in camera-type eye
GO:0019062 virion attachment to host cell

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1015 Disulfide bond
KW-0393 Immunoglobulin domain
KW-0472 Membrane
KW-1185 Reference proteome
KW-0677 Repeat
KW-0732 Signal
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR041849 Nectin-1_Ig1
IPR041850 Nectin-1_Ig2
IPR033314 Nectin1

PROSITE

PROSITE ID PROSITE Term
PS50835 IG_LIKE

Pfam

Pfam ID Pfam Term
PF08205 C2-set_2
PF07686 V-set