Gene: Nectin1

Basic information

Tag Content
Uniprot ID Q9JKF6; Q6P9M9; Q9ERL5; Q9JI17;
Entrez ID 58235
Genbank protein ID AAG22808.1; AAF60333.1; AAH60694.1; AAF76195.1;
Genbank nucleotide ID NM_021424.2
Ensembl protein ID ENSMUSP00000034510
Ensembl nucleotide ID ENSMUSG00000032012
Gene name Nectin-1
Gene symbol Nectin1
Organism Mus musculus
NCBI taxa ID 10090
Cleft type
Developmental stage E15.0
Data sources Homology search
Reference
Functional description Involved in cell adhesion and synaptogegesis. Has some neurite outgrowth-promoting activity. Receptor for alphaherpesvirus (HSV-1, HSV-2 and pseudorabies virus) entry into cells.
Sequence
MARMGLAGAA GRWWGLALGL TAFFLPGTHT QVVQVNDSMY GFIGTDVVLH CSFANPLPSV 60
KITQVTWQKA SNGSKQNMAI YNPTMGVSVL PPYEKRVEFL RPSFIDGTIR LSGLELEDEG 120
MYICEFATFP TGNRESQLNL TVMAKPTNWI EGTRAVLRAR KGQDDKVLVA TCTSANGKPP 180
SAVSWETRLK GEAEYQEIRN PNGTVTVISR YRLVPSREAH RQSLACIVNY HLDRFRESLT 240
LNVQYEPEVT IEGFDGNWYL QRTDVKLTCK ADANPPATEY HWTTLNGSLP KGVEAQNRTL 300
FFRGPITYSL AGTYICEATN PIGTRSGQVE VNITEFPYTP TPEHGRRAGQ MPTAIIGGVA 360
GSVLLVLIVV GGIIVALRRR RHTFKGDYST KKHVYGNGYS KAGIPQHHPP MAQNLQYPDD 420
SDDEKKAGPL GGSSYEEEEE EEGGGGGERK VGGPHPKYDE DAKRPYFTVD EAEARQDGYG 480
DRTLGYQYDP EQLDLAENMV SQNDGSFISK KEWYV 515

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression during embryonic days (E11.5~E18.5) ~ adult days (Ps) in the lip and palate tissues. (X-axis: days, Y-axis: tissues)

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Protein structural annotations

3D structure in PDB database


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Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologNECTIN1489363F1PCB6Canis lupus familiarisPredictionMore>>
1:1 orthologNECTIN1A0A452G6R9Capra hircusPredictionMore>>
1:1 orthologNECTIN15818Q15223Homo sapiensPublicationMore>>
1:1 orthologNectin158235Q9JKF6E15.0Mus musculusPredictionMore>>
1:1 orthologNECTIN1H2Q4Y8Pan troglodytesPredictionMore>>
1:1 orthologNECTIN1F1S9T5Sus scrofaPredictionMore>>
1:1 orthologNectin1192183F1LNP8Rattus norvegicusPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0005515 protein bindingIPI
GO:0030246 carbohydrate bindingISO
GO:0038023 signaling receptor activityIDA
GO:0038023 signaling receptor activityIBA
GO:0042802 identical protein bindingISO
GO:0042803 protein homodimerization activityIDA
GO:0042803 protein homodimerization activityIBA
GO:0044877 protein-containing complex bindingISO
GO:0046790 virion bindingISO
GO:0050839 cell adhesion molecule bindingISO
GO:0050839 cell adhesion molecule bindingIBA

GO:Biological Process

GO ID GO Term Evidence
GO:0002089 lens morphogenesis in camera-type eyeIMP
GO:0002934 desmosome organizationIMP
GO:0006826 iron ion transportIMP
GO:0007156 homophilic cell adhesion via plasma membrane adhesion moleculesIDA
GO:0007156 homophilic cell adhesion via plasma membrane adhesion moleculesIBA
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesIDA
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesIBA
GO:0007411 axon guidanceISO
GO:0019062 virion attachment to host cellIEA
GO:0046718 viral entry into host cellISO
GO:0048593 camera-type eye morphogenesisIMP
GO:0051963 regulation of synapse assemblyISO
GO:0060041 retina development in camera-type eyeIMP
GO:0070166 enamel mineralizationIMP
GO:0098609 cell-cell adhesionIMP
GO:1902414 protein localization to cell junctionIDA

GO:Cellular Component

GO ID GO Term Evidence
GO:0005886 plasma membraneISO
GO:0005912 adherens junctionISO
GO:0005912 adherens junctionIDA
GO:0005912 adherens junctionIBA
GO:0016021 integral component of membraneISO
GO:0030424 axonISO
GO:0030425 dendriteISO
GO:0032584 growth cone membraneISO
GO:0043005 neuron projectionISO
GO:0043231 intracellular membrane-bounded organelleISO
GO:0043296 apical junction complexIDA
GO:0044291 cell-cell contact zoneIDA
GO:0045202 synapseISO
GO:0098686 hippocampal mossy fiber to CA3 synapseIDA
GO:0099059 integral component of presynaptic active zone membraneIDA

Reactome Pathway

Reactome ID Reactome Term Evidence
R-MMU-1500931 Cell-Cell communicationIEA
R-MMU-418990 Adherens junctions interactionsIEA
R-MMU-420597 Nectin/Necl trans heterodimerizationIEA
R-MMU-421270 Cell-cell junction organizationIEA
R-MMU-446728 Cell junction organizationIEA

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0002 3D-structure
KW-0130 Cell adhesion
KW-0965 Cell junction
KW-1003 Cell membrane
KW-0966 Cell projection
KW-1015 Disulfide bond
KW-0325 Glycoprotein
KW-0945 Host-virus interaction
KW-0393 Immunoglobulin domain
KW-0472 Membrane
KW-0597 Phosphoprotein
KW-0675 Receptor
KW-1185 Reference proteome
KW-0677 Repeat
KW-0732 Signal
KW-0770 Synapse
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR041849 Nectin-1_Ig1
IPR041850 Nectin-1_Ig2
IPR033314 Nectin1

PROSITE

PROSITE ID PROSITE Term
PS50835 IG_LIKE

Pfam

Pfam ID Pfam Term
PF08205 C2-set_2
PF13895 Ig_2
PF07686 V-set

Protein-miRNA interaction