Gene: ALX1

Basic information

Tag Content
Uniprot ID G1SWL0
Entrez ID 100354176
Genbank protein ID
Genbank nucleotide ID XM_002711374.3
Ensembl protein ID ENSOCUP00000007877
Ensembl nucleotide ID ENSOCUG00000009125
Gene name ALX homeobox 1
Gene symbol ALX1
Organism Oryctolagus cuniculus
NCBI taxa ID 9986
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MEFLSEKFAL KSPPSKNSDF YMGAGGALEH VMETLDNEPF YSKASAGKCV QAFGPLPRAE 60
HHVRLERTSP CQDSGVNYGI TKVEGQPLHT ELNRAMDNCS SLRMSPGKGM PEKGELDELG 120
DKCDSNVSSS KKRRHRTTFT SLQLEELEKV FQKTHYPDVY VREQLALRTE LTEARVQVWF 180
QNRRAKWRKR ERYGQIQQAK SHFAATYDIS VLPRTDSYPQ IQNNLWAGNA SGGSVVTSCM 240
LPRDTSSCMT PYSHSPRTDS SYTGFSNHQN QFSHVPLNNF FTDSLLTGAT NGHAFETKPE 300
FERRSSSIAV LRMKAKEHTA NISWAM 326

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologALX1102168422A0A452G2P5Capra hircusPredictionMore>>
1:1 orthologALX18092Q15699Homo sapiensPredictionMore>>
1:1 orthologAlx1216285Q8C8B0CPOMus musculusPublicationMore>>
1:1 orthologALX1452109H2Q6K1Pan troglodytesPredictionMore>>
1:1 orthologALX1100525700A0A287AYX1Sus scrofaPredictionMore>>
1:1 orthologALX1100354176G1SWL0Oryctolagus cuniculusPredictionMore>>
1:1 orthologAlx125401Q63087Rattus norvegicusPredictionMore>>
1:1 orthologalx1565176Q1LVQ7Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005794 Golgi apparatus
GO:0016604 nuclear body
GO:0005667 transcription factor complex
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0009952 anterior/posterior pattern specification
GO:0030326 embryonic limb morphogenesis
GO:0048704 embryonic skeletal system morphogenesis
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001755 neural crest cell migration
GO:0001843 neural tube closure
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0060021 roof of mouth development

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0217 Developmental protein
KW-0238 DNA-binding
KW-0371 Homeobox
KW-0539 Nucleus
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR033209 ALX1
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR003654 OAR_dom

PROSITE

PROSITE ID PROSITE Term
PS00027 HOMEOBOX_1
PS50071 HOMEOBOX_2
PS50803 OAR

Pfam

Pfam ID Pfam Term
PF00046 Homeodomain
PF03826 OAR