| Tag | Content |
|---|---|
| Uniprot ID | Q1LVQ7 |
| Entrez ID | 565176 |
| Genbank protein ID | CAK11128.1 |
| Genbank nucleotide ID | NM_001045074.1 |
| Ensembl protein ID | ENSDARP00000123391; ENSDARP00000148539; ENSDARP00000150329; |
| Ensembl nucleotide ID | ENSDARG00000115230; ENSDARG00000062824; ENSDARG00000110530; |
| Gene name | ALX homeobox protein 1 |
| Gene symbol | alx1 |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes. Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures (By similarity). Required for proper neural crest cell migration into the frontonasal primordia during development (PubMed:23059813). |
| Sequence | MEYLSDKFSL KSPAIKGSDY YMDQVMDTLD NVQYYNKASP KCVQAFPMQS NDQHSSMDRS 60 SPCDNQSSVT YCAPKSEESS LHAMENCCSL RVSPATSGPD KTDLDELGEK CDSNVSSSKK 120 RRHRTTFTSA QLEELEKVFQ KTHYPDVYVR EQLAMRTELT EARVQVWFQN RRAKWRKRER 180 YGQIQQAKSH FAATYDISML PRTDSYSQIS NNLWTGPSAG SSVVSSCMIP RGSPPCVTSP 240 YPHSPRAAEH GYVGFPNHQQ NQFGVNHVSL NNFFADSLLA SSANSHAAFE TKPEFERRSS 300 SIAVLRMKAK EHTANISWAM |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ALX1 | 102168422 | A0A452G2P5 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | ALX1 | 8092 | Q15699 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Alx1 | 216285 | Q8C8B0 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | ALX1 | 452109 | H2Q6K1 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | ALX1 | 100525700 | A0A287AYX1 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | ALX1 | 100354176 | G1SWL0 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Alx1 | 25401 | Q63087 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | alx1 | 565176 | Q1LVQ7 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| GO:0048701 | embryonic cranial skeleton morphogenesis |
| GO:0048704 | embryonic skeletal system morphogenesis |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0001755 | neural crest cell migration |
| GO:0010718 | positive regulation of epithelial to mesenchymal transition |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| GO:0006357 | regulation of transcription by RNA polymerase II |