| Tag | Content |
|---|---|
| Uniprot ID | H2Q6K1; A0A2J8MIM6; |
| Entrez ID | 452109 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_509250.6 |
| Ensembl protein ID | ENSPTRP00000008963 |
| Ensembl nucleotide ID | ENSPTRG00000005272 |
| Gene name | ALX homeobox 1 |
| Gene symbol | ALX1 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MEFLSEKFAL KSPPSKNSDF YMGAGGPLEH VMETLDNESF YSKASAGKCV QAFGPLPRAE 60 HHVRLERTSP CQDSSVNYGI TKVEGQPLHT ELNRAMDNCN SLRMSPVKGM QEKGELDELG 120 DKCDSNVSSS KKRRHRTTFT SLQLEELEKV FQKTHYPDVY VREQLALRTE LTEARVQVWF 180 QNRRAKWRKR ERYGQIQQAK SHFAATYDIS VLPRTDSYPQ IQNNLWAGNA SGGSVVTSCM 240 LPRDTSSCMT PYSHSPRTDS SYTGFSNHQN QFSHVPLNNF FTDSLLTGAT NGHAFETKPE 300 FERRSSSIAV LRMKAKEHTA NISWAM 326 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ALX1 | 102168422 | A0A452G2P5 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | ALX1 | 8092 | Q15699 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Alx1 | 216285 | Q8C8B0 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | ALX1 | 452109 | H2Q6K1 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | ALX1 | 100525700 | A0A287AYX1 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | ALX1 | 100354176 | G1SWL0 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Alx1 | 25401 | Q63087 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | alx1 | 565176 | Q1LVQ7 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005794 | Golgi apparatus |
| GO:0016604 | nuclear body |
| GO:0005634 | nucleus |
| GO:0005667 | transcription factor complex |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| GO:0009952 | anterior/posterior pattern specification |
| GO:0030326 | embryonic limb morphogenesis |
| GO:0048704 | embryonic skeletal system morphogenesis |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0001755 | neural crest cell migration |
| GO:0001843 | neural tube closure |
| GO:0010718 | positive regulation of epithelial to mesenchymal transition |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0060021 | roof of mouth development |