Gene: ALX3

Basic information

Tag Content
Uniprot ID H2PZM0; A0A2J8JXJ8;
Entrez ID 469416
Genbank protein ID
Genbank nucleotide ID XM_524801.6
Ensembl protein ID ENSPTRP00000001851
Ensembl nucleotide ID ENSPTRG00000001070
Gene name ALX homeobox 3
Gene symbol ALX3
Organism Pan troglodytes
NCBI taxa ID 9598
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MDPEHCAPFR VGPAPGPYVA SRDEPPGPQG TPAAAPHLHP APPRGPRLTR FPACGPLEPY 60
LPEPAKPPAK YLQDLGPGPA LNGGHFYEGP AEAEEKTSKA ASFPQLPLDC RGGPRDGPSN 120
LQGSPGPCLA SLHLPLSPGL PDSMELAKNK SKKRRNRTTF STFQLEELEK VFQKTHYPDV 180
YAREQLALRT DLTEARVQVW FQNRRAKWRK RERYGKIQEG RNPFTAAYDI SVLPRTDSHP 240
QLQNSLWASP GSGSPGGPCL VSPEGIPSPC MSPYSHPHGS VAGFMGVPAP SAAHPGIYSI 300
HGFPPTLGGH SFEPSSDGDY KSPSLVSLRV KPKEPPGLLN WTT 343

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologALX3102184773A0A452G5Q5Capra hircusPredictionMore>>
1:1 orthologALX3257O95076Homo sapiensPredictionMore>>
1:1 orthologAlx311694O70137CPOMus musculusPublicationMore>>
1:1 orthologALX3469416H2PZM0Pan troglodytesPredictionMore>>
1:1 orthologALX3F1S615Sus scrofaPredictionMore>>
1:1 orthologALX3100355559G1SXT4Oryctolagus cuniculusPredictionMore>>
1:1 orthologAlx3F1LN97Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005634 nucleus
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0035115 embryonic forelimb morphogenesis
GO:0035116 embryonic hindlimb morphogenesis
GO:0007389 pattern specification process
GO:0042981 regulation of apoptotic process

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0238 DNA-binding
KW-0371 Homeobox
KW-0539 Nucleus
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR033211 ALX3
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom

PROSITE

PROSITE ID PROSITE Term
PS00027 HOMEOBOX_1
PS50071 HOMEOBOX_2

Pfam

Pfam ID Pfam Term
PF00046 Homeodomain