Gene: Alx3

Basic information

Tag Content
Uniprot ID O70137
Entrez ID 11694
Genbank protein ID AAC15094.1
Genbank nucleotide ID NM_007441.3
Ensembl protein ID ENSMUSP00000014747
Ensembl nucleotide ID ENSMUSG00000014603
Gene name Homeobox protein aristaless-like 3
Gene symbol Alx3
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage
Data sources Manually collected
Reference 11641221
Functional description Transcriptional regulator with a possible role in patterning of mesoderm during development.
Sequence
MDPERCAPFS VGPAAGPYAA AGDEAPGPQG TPDAAPHLHP APPRGPRLSR FPACGPLEPY 60
LPEPAKPPAK YLQDLGPGPV LNGGHFYEGS AEAEEKASKA ASFPQLPVDC RGGPRDGPSN 120
VQASPGPCLA SLSVPLSPGL PDSMELAKTK SKKRRNRTTF STFQLEELEK VFQKTHYPDV 180
YAREQLALRT DLTEARVQVW FQNRRAKWRK RERYGKMQEG RNPFTTAYDI SVLPRTDSHP 240
QLQNSLWPSP GSGSPGGPCL MSPEGIPSPC MSPYSHSHGN VAGFMGVPAS PAAHPGIYSI 300
HGFPPALGGH SFEPSPDGDY KSPSLVSLRM KPKEPPGLLN WTT 343

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologALX3102184773A0A452G5Q5Capra hircusPredictionMore>>
1:1 orthologALX3257O95076Homo sapiensPredictionMore>>
1:1 orthologAlx311694O70137CPOMus musculusPublicationMore>>
1:1 orthologALX3469416H2PZM0Pan troglodytesPredictionMore>>
1:1 orthologALX3F1S615Sus scrofaPredictionMore>>
1:1 orthologALX3100355559G1SXT4Oryctolagus cuniculusPredictionMore>>
1:1 orthologAlx3F1LN97Rattus norvegicusPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA bindingIBA
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specificIBA
GO:0003677 DNA bindingISO
GO:0003700 DNA-binding transcription factor activityISO

GO:Biological Process

GO ID GO Term Evidence
GO:0006355 regulation of transcription, DNA-templatedISO
GO:0006357 regulation of transcription by RNA polymerase IIIEA
GO:0007389 pattern specification processIGI
GO:0035115 embryonic forelimb morphogenesisIGI
GO:0035116 embryonic hindlimb morphogenesisIGI
GO:0042981 regulation of apoptotic processIGI
GO:0048701 embryonic cranial skeleton morphogenesisIEA
GO:0048704 embryonic skeletal system morphogenesisIGI

GO:Cellular Component

GO ID GO Term Evidence
GO:0005634 nucleusISO
GO:0005634 nucleusIBA

Reactome Pathway

Reactome ID Reactome Term Evidence

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0217 Developmental protein
KW-0238 DNA-binding
KW-0371 Homeobox
KW-0539 Nucleus
KW-1185 Reference proteome
KW-0804 Transcription
KW-0805 Transcription regulation

Interpro

InterPro ID InterPro Term
IPR033211 ALX3
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom

PROSITE

PROSITE ID PROSITE Term
PS00027 HOMEOBOX_1
PS50071 HOMEOBOX_2

Pfam

Pfam ID Pfam Term
PF00046 Homeodomain

Protein-protein interaction