| Tag | Content |
|---|---|
| Uniprot ID | H2QCD5; A0A2J8J358; |
| Entrez ID | 454478 |
| Genbank protein ID | JAA22330.1; JAA39403.1; JAA19077.1; JAA01417.1; |
| Genbank nucleotide ID | XM_001159854.4 |
| Ensembl protein ID | ENSPTRP00000015059 |
| Ensembl nucleotide ID | ENSPTRG00000008832 |
| Gene name | Phosphatidylethanolamine N-methyltransferase |
| Gene symbol | PEMT |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC). |
| Sequence | MKRSGNPGAE ATNSSVAGPD CCGGLGNIDF RQADFCVMTR LLGYVDPLDP SFVAAVVTIT 60 FNPLYWNVVA RWEHKTRKLS RAFGSPYLAC YSLSVTILLL NFLRSHCFMQ AMLSQPRMES 120 LDTPAAYSLG LTLLGLGVVL VLSSFFALGF TGTFLGDYFG ILKEARVTVF PFNILDNPMY 180 WGSTANYLGW AIMHASPTGL LLTVLVALTY IVALLYEEPF TAEIYRQKAS GSHKRS 236 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PEMT | 479526 | J9P3L9 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | PEMT | 102170908 | A0A452DY36 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | PEMT | 10400 | Q9UBM1 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Pemt | 18618 | Q61907 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | PEMT | 454478 | H2QCD5 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | PEMT | 397654 | Q7YRH5 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Pemt | 25511 | Q08388 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005789 | endoplasmic reticulum membrane |
| GO:0016021 | integral component of membrane |
| GO:0031966 | mitochondrial membrane |
| GO:0080101 | phosphatidyl-N-dimethylethanolamine N-methyltransferase activity |
| GO:0000773 | phosphatidyl-N-methylethanolamine N-methyltransferase activity |
| GO:0004608 | phosphatidylethanolamine N-methyltransferase activity |
| GO:0001835 | blastocyst hatching |
| GO:0032259 | methylation |
| GO:0006656 | phosphatidylcholine biosynthetic process |
| GO:0120162 | positive regulation of cold-induced thermogenesis |
| GO:0006686 | sphingomyelin biosynthetic process |
| Keyword ID | Keyword Term |
|---|---|
| KW-0256 | Endoplasmic reticulum |
| KW-0444 | Lipid biosynthesis |
| KW-0443 | Lipid metabolism |
| KW-0472 | Membrane |
| KW-0489 | Methyltransferase |
| KW-0496 | Mitochondrion |
| KW-0594 | Phospholipid biosynthesis |
| KW-1208 | Phospholipid metabolism |
| KW-1185 | Reference proteome |
| KW-0949 | S-adenosyl-L-methionine |
| KW-0808 | Transferase |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51599 | SAM_PEMT_PEM2 |
| Pfam ID | Pfam Term |
|---|---|
| PF04191 | PEMT |