| Tag | Content |
|---|---|
| Uniprot ID | J9P3L9 |
| Entrez ID | 479526 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_536665.4 |
| Ensembl protein ID | ENSCAFP00000040148 |
| Ensembl nucleotide ID | ENSCAFG00000028791 |
| Gene name | Phosphatidylethanolamine N-methyltransferase |
| Gene symbol | PEMT |
| Organism | Canis lupus familiaris |
| NCBI taxa ID | 9615 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC). |
| Sequence | MSSSVAGPDC CGGLGNVDFR QADLCVMTWL LGYVDPSDPC FVAAILTIAF NPLFWNVVAR 60 WEQKTRKLSK AFRSPYLACY SLGAAILLLN ILRSHCFTQA MLSQPKMESL DNPMAYRVGL 120 ALLGVGSTFV LSSFFALGFT GTFLGDYFGI LKEARVTTFP FNILDNPMYW GSTANYLGWA 180 VMHASPTGLL LTVVVALIYR VAILYEEPFT AQIYQQKASS SHKRS 225 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.