Gene: PEMT

Basic information

Tag Content
Uniprot ID J9P3L9
Entrez ID 479526
Genbank protein ID
Genbank nucleotide ID XM_536665.4
Ensembl protein ID ENSCAFP00000040148
Ensembl nucleotide ID ENSCAFG00000028791
Gene name Phosphatidylethanolamine N-methyltransferase
Gene symbol PEMT
Organism Canis lupus familiaris
NCBI taxa ID 9615
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC).
Sequence
MSSSVAGPDC CGGLGNVDFR QADLCVMTWL LGYVDPSDPC FVAAILTIAF NPLFWNVVAR 60
WEQKTRKLSK AFRSPYLACY SLGAAILLLN ILRSHCFTQA MLSQPKMESL DNPMAYRVGL 120
ALLGVGSTFV LSSFFALGFT GTFLGDYFGI LKEARVTTFP FNILDNPMYW GSTANYLGWA 180
VMHASPTGLL LTVVVALIYR VAILYEEPFT AQIYQQKASS SHKRS 225

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologPEMT479526J9P3L9Canis lupus familiarisPredictionMore>>
1:1 orthologPEMT102170908A0A452DY36Capra hircusPredictionMore>>
1:1 orthologPEMT10400Q9UBM1Homo sapiensPublicationMore>>
1:1 orthologPemt18618Q61907Mus musculusPredictionMore>>
1:1 orthologPEMT454478H2QCD5Pan troglodytesPredictionMore>>
1:1 orthologPEMT397654Q7YRH5Sus scrofaPredictionMore>>
1:1 orthologPemt25511Q08388Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0031966 mitochondrial membrane
GO:0080101 phosphatidyl-N-dimethylethanolamine N-methyltransferase activity
GO:0000773 phosphatidyl-N-methylethanolamine N-methyltransferase activity
GO:0004608 phosphatidylethanolamine N-methyltransferase activity
GO:0032259 methylation
GO:0006656 phosphatidylcholine biosynthetic process

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0256 Endoplasmic reticulum
KW-0444 Lipid biosynthesis
KW-0443 Lipid metabolism
KW-0472 Membrane
KW-0489 Methyltransferase
KW-0496 Mitochondrion
KW-0594 Phospholipid biosynthesis
KW-1208 Phospholipid metabolism
KW-1185 Reference proteome
KW-0949 S-adenosyl-L-methionine
KW-0808 Transferase
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR024960 PEMT/MFAP
IPR007318 Phopholipid_MeTrfase

PROSITE

PROSITE ID PROSITE Term
PS51599 SAM_PEMT_PEM2

Pfam

Pfam ID Pfam Term
PF04191 PEMT