| Tag | Content |
|---|---|
| Uniprot ID | H2RA86; A0A2J8ISY9; K7CQE8; |
| Entrez ID | 454037 |
| Genbank protein ID | JAA26435.1 |
| Genbank nucleotide ID | XM_016928783.1 |
| Ensembl protein ID | ENSPTRP00000053615 |
| Ensembl nucleotide ID | ENSPTRG00000007988 |
| Gene name | Mitogen-activated protein kinase |
| Gene symbol | MAPK3 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MAAAAAQGGG GGEPRRTEGV GPGVPGEVEM VKGQPFDVGP RYTQLQYIGE GAYGMVSSAY 60 DHVRKTRVAI KKISPFEHQT YCQRTLREIQ ILLRFRHENV IGIRDILRAS TLEAMRDVYI 120 VQDLMETDLY KLLKSQQLSN DHICYFLYQI LRGLKYIHSA NVLHRDLKPS NLLINTTCDL 180 KICDFGLARI ADPEHDHTGF LTEYVATRWY RAPEIMLNSK GYTKSIDIWS VGCILAEMLS 240 NRPIFPGKHY LDQLNHILGI LGSPSQEDLN CIINMKARNY LQSLPSKTKV AWAKLFPKSD 300 SKALDLLDRM LTFNPNKRIT VEEALAHPYL EQYYDPTDEP VAEEPFTFAM ELDDLPKERL 360 KELIFQETAR FQPGVLEAP 379 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MAPK3 | 531391 | A0A3Q1MNN7 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | MAPK3 | A0A452ETI1 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | MAPK3 | 5595 | P27361 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Mapk3 | 26417 | Q63844 | CPO | E13.5, E14.5, E15.5, E16.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | MAPK3 | 454037 | H2RA86 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | A0A480NH74 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | Mapk3 | 50689 | P21708 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | mapk3 | 399480 | Q7ZVK8 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005623 | cell |
| GO:0005737 | cytoplasm |
| GO:0005829 | cytosol |
| GO:0005635 | nuclear envelope |
| GO:0005634 | nucleus |
| GO:0031143 | pseudopodium |
| GO:0005524 | ATP binding |
| GO:0042802 | identical protein binding |
| GO:0004707 | MAP kinase activity |
| GO:0004708 | MAP kinase kinase activity |
| GO:0019902 | phosphatase binding |
| GO:0001784 | phosphotyrosine residue binding |
| GO:0060020 | Bergmann glial cell differentiation |
| GO:0030509 | BMP signaling pathway |
| GO:0061308 | cardiac neural crest cell development involved in heart development |
| GO:0051216 | cartilage development |
| GO:0007166 | cell surface receptor signaling pathway |
| GO:0034198 | cellular response to amino acid starvation |
| GO:0071276 | cellular response to cadmium ion |
| GO:1903351 | cellular response to dopamine |
| GO:0071260 | cellular response to mechanical stimulus |
| GO:0071310 | cellular response to organic substance |
| GO:0034614 | cellular response to reactive oxygen species |
| GO:0071356 | cellular response to tumor necrosis factor |
| GO:0006975 | DNA damage induced protein phosphorylation |
| GO:0070371 | ERK1 and ERK2 cascade |
| GO:0060324 | face development |
| GO:0070498 | interleukin-1-mediated signaling pathway |
| GO:0035556 | intracellular signal transduction |
| GO:0031663 | lipopolysaccharide-mediated signaling pathway |
| GO:0060425 | lung morphogenesis |
| GO:2000657 | negative regulation of apolipoprotein binding |
| GO:0042473 | outer ear morphogenesis |
| GO:0038083 | peptidyl-tyrosine autophosphorylation |
| GO:0031281 | positive regulation of cyclase activity |
| GO:0002741 | positive regulation of cytokine secretion involved in immune response |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| GO:0035066 | positive regulation of histone acetylation |
| GO:0033129 | positive regulation of histone phosphorylation |
| GO:0010759 | positive regulation of macrophage chemotaxis |
| GO:1905050 | positive regulation of metallopeptidase activity |
| GO:0051973 | positive regulation of telomerase activity |
| GO:1904355 | positive regulation of telomere capping |
| GO:0032212 | positive regulation of telomere maintenance via telomerase |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:1904417 | positive regulation of xenophagy |
| GO:0030641 | regulation of cellular pH |
| GO:0051090 | regulation of DNA-binding transcription factor activity |
| GO:0010468 | regulation of gene expression |
| GO:0030278 | regulation of ossification |
| GO:0070849 | response to epidermal growth factor |
| GO:0043330 | response to exogenous dsRNA |
| GO:0019233 | sensory perception of pain |
| GO:0051403 | stress-activated MAPK cascade |
| GO:0048538 | thymus development |
| GO:0030878 | thyroid gland development |
| GO:0060440 | trachea formation |
| GO:0006351 | transcription, DNA-templated |
| Pfam ID | Pfam Term |
|---|---|
| PF00069 | Pkinase |