Gene: Slc32a1

Basic information

Tag Content
Uniprot ID O35458
Entrez ID 83612
Genbank protein ID AAB82950.1
Genbank nucleotide ID NM_031782.1; XM_006235441.3;
Ensembl protein ID ENSRNOP00000020720
Ensembl nucleotide ID ENSRNOG00000015393
Gene name Vesicular inhibitory amino acid transporter
Gene symbol Slc32a1
Organism Rattus norvegicus
NCBI taxa ID 10116
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Involved in the uptake of GABA and glycine into the synaptic vesicles.
Sequence
MATLLRSKLT NVATSVSNKS QAKVSGMFAR MGFQAATDEE AVGFAHCDDL DFEHRQGLQM 60
DILKSEGEPC GDEGAEPPVE GDIHYQRGGA PLPPSGSKDQ AVGAGGEFGG HDKPKITAWE 120
AGWNVTNAIQ GMFVLGLPYA ILHGGYLGLF LIIFAAVVCC YTGKILIACL YEENEDGEVV 180
RVRDSYVAIA NACCAPRFPT LGGRVVNVAQ IIELVMTCIL YVVVSGNLMY NSFPGLPVSQ 240
KSWSIIATAV LLPCAFLKNL KAVSKFSLLC TLAHFVINIL VIAYCLSRAR DWAWEKVKFY 300
IDVKKFPISI GIIVFSYTSQ IFLPSLEGNM QQPSEFHCMM NWTHIAACVL KGLFALVAYL 360
TWADETKEVI TDNLPGSIRA VVNIFLVAKA LLSYPLPFFA AVEVLEKSLF QEGSRAFFPA 420
CYGGDGRLKS WGLTLRCALV VFTLLMAIYV PHFALLMGLT GSLTGAGLCF LLPSLFHLRL 480
LWRKLLWHQV FFDVAIFVIG GICSVSGFVH SLEGLIEAYR TNAED 525

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologSLC32A1100301361G3N354Bos taurusPredictionMore>>
1:1 orthologSLC32A1485870E2QU68Canis lupus familiarisPredictionMore>>
1:1 orthologSLC32A1102180509A0A452E4X8Capra hircusPredictionMore>>
1:1 orthologSLC32A1140679Q9H598Homo sapiensPredictionMore>>
1:1 orthologSlc32a122348O35633CPOE14.5Mus musculusPublicationMore>>
1:1 orthologSLC32A1469940H2QKC6Pan troglodytesPredictionMore>>
1:1 orthologSLC32A1100517013F1SDX2Sus scrofaPredictionMore>>
1:1 orthologSLC32A1U3KMK1Oryctolagus cuniculusPredictionMore>>
1:1 orthologSlc32a183612O35458Rattus norvegicusPredictionMore>>
1:1 orthologslc32a1798575A1L1T3Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0051286 cell tip
GO:0044316 cone cell pedicle
GO:0030425 dendrite
GO:0044292 dendrite terminus
GO:0098982 GABA-ergic synapse
GO:0060077 inhibitory synapse
GO:0016021 integral component of membrane
GO:0030285 integral component of synaptic vesicle membrane
GO:0043229 intracellular organelle
GO:0043005 neuron projection
GO:0044306 neuron projection terminus
GO:0048786 presynaptic active zone
GO:0045202 synapse
GO:0008021 synaptic vesicle
GO:0015171 amino acid transmembrane transporter activity
GO:0015495 gamma-aminobutyric acid:proton symporter activity
GO:0015187 glycine transmembrane transporter activity
GO:0007568 aging
GO:0003333 amino acid transmembrane transport
GO:0015812 gamma-aminobutyric acid transport
GO:0015816 glycine transport
GO:0021766 hippocampus development
GO:0098700 neurotransmitter loading into synaptic vesicle
GO:0006836 neurotransmitter transport

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0968 Cytoplasmic vesicle
KW-0325 Glycoprotein
KW-0472 Membrane
KW-0532 Neurotransmitter transport
KW-0944 Nitration
KW-1185 Reference proteome
KW-0812 Transmembrane
KW-1133 Transmembrane helix
KW-0813 Transport

Interpro

InterPro ID InterPro Term
IPR013057 AA_transpt_TM

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF01490 Aa_trans