Gene: Slc32a1

Basic information

Tag Content
Uniprot ID O35633
Entrez ID 22348
Genbank protein ID BAC44889.1; AAH52020.1; BAC44888.1; CAA04864.1;
Genbank nucleotide ID NM_009508.2
Ensembl protein ID ENSMUSP00000036299
Ensembl nucleotide ID ENSMUSG00000037771
Gene name Vesicular inhibitory amino acid transporter
Gene symbol Slc32a1
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage E14.5
Data sources Manually collected
Reference 20333300; 16701208; 9177246;
Functional description Involved in the uptake of GABA and glycine into the synaptic vesicles.
Sequence
MATLLRSKLT NVATSVSNKS QAKVSGMFAR MGFQAATDEE AVGFAHCDDL DFEHRQGLQM 60
DILKSEGEPC GDEGAEAPVE GDIHYQRGGA PLPPSGSKDQ AVGAGGEFGG HDKPKITAWE 120
AGWNVTNAIQ GMFVLGLPYA ILHGGYLGLF LIIFAAVVCC YTGKILIACL YEENEDGEVV 180
RVRDSYVAIA NACCAPRFPT LGGRVVNVAQ IIELVMTCIL YVVVSGNLMY NSFPGLPVSQ 240
KSWSIIATAV LLPCAFLKNL KAVSKFSLLC TLAHFVINIL VIAYCLSRAR DWAWEKVKFY 300
IDVKKFPISI GIIVFSYTSQ IFLPSLEGNM QQPSEFHCMM NWTHIAACVL KGLFALVAYL 360
TWADETKEVI TDNLPGSIRA VVNLFLVAKA LLSYPLPFFA AVEVLEKSLF QEGSRAFFPA 420
CYGGDGRLKS WGLTLRCALV VFTLLMAIYV PHFALLMGLT GSLTGAGLCF LLPSLFHLRL 480
LWRKLLWHQV FFDVAIFVIG GICSVSGFVH SLEGLIEAYR TNAED 525

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression during embryonic days (E11.5~E18.5) ~ adult days (Ps) in the lip and palate tissues. (X-axis: days, Y-axis: tissues)

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Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologSLC32A1100301361G3N354Bos taurusPredictionMore>>
1:1 orthologSLC32A1485870E2QU68Canis lupus familiarisPredictionMore>>
1:1 orthologSLC32A1102180509A0A452E4X8Capra hircusPredictionMore>>
1:1 orthologSLC32A1140679Q9H598Homo sapiensPredictionMore>>
1:1 orthologSlc32a122348O35633CPOE14.5Mus musculusPublicationMore>>
1:1 orthologSLC32A1469940H2QKC6Pan troglodytesPredictionMore>>
1:1 orthologSLC32A1100517013F1SDX2Sus scrofaPredictionMore>>
1:1 orthologSLC32A1U3KMK1Oryctolagus cuniculusPredictionMore>>
1:1 orthologSlc32a183612O35458Rattus norvegicusPredictionMore>>
1:1 orthologslc32a1798575A1L1T3Danio rerioPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0015171 amino acid transmembrane transporter activityIBA
GO:0015187 glycine transmembrane transporter activityIDA
GO:0015495 gamma-aminobutyric acid:proton symporter activityIBA
GO:0015495 gamma-aminobutyric acid:proton symporter activityIDA

GO:Biological Process

GO ID GO Term Evidence
GO:0003333 amino acid transmembrane transportIBA
GO:0007568 agingIEA
GO:0015812 gamma-aminobutyric acid transportISO
GO:0015816 glycine transportIDA
GO:0021766 hippocampus developmentIEA
GO:0098700 neurotransmitter loading into synaptic vesicleISO
GO:0098700 neurotransmitter loading into synaptic vesicleIBA

GO:Cellular Component

GO ID GO Term Evidence
GO:0005887 integral component of plasma membraneIC
GO:0008021 synaptic vesicleISO
GO:0030285 integral component of synaptic vesicle membraneISO
GO:0030285 integral component of synaptic vesicle membraneIBA
GO:0030425 dendriteISO
GO:0043005 neuron projectionIDA
GO:0043005 neuron projectionISO
GO:0043229 intracellular organelleISO
GO:0044292 dendrite terminusIDA
GO:0044292 dendrite terminusIBA
GO:0044306 neuron projection terminusIDA
GO:0044306 neuron projection terminusISO
GO:0044306 neuron projection terminusIBA
GO:0044316 cone cell pedicleIDA
GO:0045202 synapseISO
GO:0048786 presynaptic active zoneIDA
GO:0051286 cell tipIDA
GO:0060077 inhibitory synapseISO
GO:0060077 inhibitory synapseIDA
GO:0098982 GABA-ergic synapseISO

Reactome Pathway

Reactome ID Reactome Term Evidence
R-MMU-112310 Neurotransmitter release cycleIEA
R-MMU-112315 Transmission across Chemical SynapsesIEA
R-MMU-112316 Neuronal SystemIEA
R-MMU-382551 Transport of small moleculesIEA
R-MMU-425393 Transport of inorganic cations/anions and amino acids/oligopeptidesIEA
R-MMU-425407 SLC-mediated transmembrane transportIEA
R-MMU-888590 GABA synthesis, release, reuptake and degradationIEA

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0025 Alternative splicing
KW-0968 Cytoplasmic vesicle
KW-0325 Glycoprotein
KW-0472 Membrane
KW-0532 Neurotransmitter transport
KW-0944 Nitration
KW-1185 Reference proteome
KW-0812 Transmembrane
KW-1133 Transmembrane helix
KW-0813 Transport

Interpro

InterPro ID InterPro Term
IPR013057 AA_transpt_TM

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF01490 Aa_trans

Protein-miRNA interaction